Ke Xu Group


We are an interdisciplinary lab that develops new physicochemical tools to interrogate biological, chemical, and materials systems at the nanoscale with extraordinary resolution, sensitivity, and functionality. To do so, we take a multidimensional approach that integrates advanced microscopy, spectroscopy, cell biology, and nanotechnology.

News


8.19.2019
Super-resolution microscopy: a new angle

Our collaboration with Xiang Zhang Lab created oblique-plane STORM, a light-sheet super-resolution method that enables direct cross-sectional imaging through up to 66 µm deep into tissues and small intact animals. [Link]

Congratulations to Jeongmin, Michal, Seonah, and all collaborators!

8.14.2019
Tailor-made switchable solvatochromic probes for live-cell superresolution imaging of plasma membrane organization

Our collaboration with Andrey Klymchenko Lab led to NR4A, a solvatochromic probe optimized for the spectrally resolved, functional super-resolution microscopy of live-cell plasma membranes. [Link]

Congratulations to Seonah and our collaborators!

8.10.2019
Graphene photochemistry and spatial heterogeneities in reactivity

Interference reflection microscopy unveils a photochemistry mechanism and rich spatial heterogeneities for the reaction of monolayer graphene with aryl diazonium. [Link]

Congratulations to Yunqi, Wan, Michal, Bowen, and our STROBE collaborators, Liang-Chun Lin and Markus Raschke!

5.20.19
Congratulations to Seonah, Shirley, Zhiheng (and Sam)!

Congratulations to Seonah, Shirley, and Zhiheng for their graduation, and also to Sam for completing his Ph.D. requirement earlier!

We are proud of you and will miss you all!

4.30.19
Multidimensional super-resolution microscopy through machine learning

Machine learning (magically) resolves both the colors and the axial positions of unmodified single-molecule images for STORM! [Link]

Great job, Taehwan and Seonah!

1.22.19
Optical microscopy unveils rapid, reversible electrochemical oxidation and reduction of graphene

Another demonstration of the power of optical microscopy for chemical reactions, in this case for electrochemistry -and graphene is reversibly oxidized and reduced! [Link]

Congratulations to Wan and Michal!

10.02.18
Ke received NIH Director's New Innovator Award!


9.4.18
Of sperms -and vesicles

See our collaborative work with the Lishko Lab and the Schekman Lab, resolving the mysteries of sperm ion channels [Link] and the large COPII-coated vesicles [Link], respectively.

Congratulations, Sam, for both papers!

8.7.18
A conserved, periodic nanoscale scaffold and ruler of the neural stem cell lineage

Our super-resolution work reveals a highly conserved one-dimensional periodic cytoskeletal motif in neural stem cells and derivatives, and shows that this periodic scaffold guides intercellular interactions as a nanoscale ruler. [Link]

Congratulations, Meg and Rui! What a tour de force!

7.5.18
Super-resolution microscopy of graphene nanoribbons

Our collaboration work with the Fischer Lab enables super-resolution microscopy for graphene nanoribbons. [Link]

Congratulations to Meg and our collaborators!

5.16.18
Congratulations to Meg, Michal, Yennie, and Manni!

Congratulations to Meg and Michal for becoming the first graduated Ph.D.'s from the Xu Lab!

Congratulations also to Yennie and Manni's graduation!

We are so proud of you and will miss you all!

4.12.18
Functional super-resolution microscopy for surface chemistry

Our new work in Nature Comm. reveals the fascinating nanoscale structure and composition of surface adlayers. [Link]

See also our other new work in ACS Nano and bioRxiv.

Congratulations to Limin, Michal, Sam, and all!

2.14.18
Our article in Accounts of Chemical Research

We summarize the rationale, design, and results of our recent efforts toward the integration of single-molecule spectroscopy with super-resolution microscopy. [Link]

Thanks go to all past and current lab members, who made this possible.

1.31.18
Resolving the native ultrastructure of the erythrocyte cytoskeleton

Super-resolution microscopy resolves the cytoskeletal meshwork of intact erythrocytes and reveals an 80 nm junction-to-junction distance. [Link]

Congratulations Leiting, Rui, and Wan!

4.5.17
Our article in JACS

Our article "Spatially resolved in situ reaction dynamics of graphene via optical microscopy" has been published in Journal of the American Chemical Society!

Congratulations Michal, Yunqi, and Wan!

1.3.17
Our article in Chemical Reviews

Our article "Correlative Super-Resolution Microscopy: New Dimensions and New Opportunities" has been published in Chemical Reviews!

Congratulations Meg, Michal, Doory, and Wan! -Great way to start a new year!

10.17.16
Ke received the Packard Fellowship for Science and Engineering!

Congratulations on your recent awards, Ke!

8.22.16
Ke named one of the Talented 12 by Chemical & Engineering News!


8.01.16
Ke received NSF CAREER Award and Beckman Young Investigators Award!


6.28.16
Our new work in Nano Letters!

Our new paper, "Direct Optical Visualization of Graphene and Its Nanoscale Defects on Transparent Substrates", has been published in Nano Letters! [Link]

Congratulations Wan, Seonah, and Michal!

2.23.16
Ke named a Sloan Research Fellow!

Ke has received the Sloan Research Fellowship!

Congratulations Ke!

8.7.15
Our new paper in Nature Methods!

Our new paper, “Ultrahigh-throughput single-molecule spectroscopy and spectrally resolved super-resolution microscopy”, has been published in Nature Methods! [Link]

See also news release by LBL: [Link]

Congratulations Zhengyang, Sam, Meg, and Wan!

6.11.15
Our first paper published in Nature Communications!

Our first paper, "Graphene-enabled electron microscopy and correlated super-resolution microscopy of wet cells," has been published in Nature Communications! [Link]

Congratulations Michal, Meg, and Seonah!