We are an interdisciplinary lab that develops new physicochemical tools to interrogate biological, chemical, and materials systems at the nanoscale with extraordinary resolution, sensitivity, and functionality. To do so, we take a multidimensional approach that integrates advanced microscopy, spectroscopy, cell biology, and nanotechnology.
A conserved, periodic nanoscale scaffold and ruler of the neural stem cell lineage
Our super-resolution work reveals a highly conserved one-dimensional periodic cytoskeletal motif in neural stem cells and derivatives, and shows that this periodic scaffold guides intercellular interactions as a nanoscale ruler. [Link]
Congratulations, Meg and Rui! What a tour de force!
Multidimensional super-resolution microscopy through machine learning
Machine learning (magically) resolves both the colors and the axial positions of unmodified single-molecule images for STORM! [Link]
Great job, Taehwan and Seonah!
Super-resolution microscopy of graphene nanoribbons
Our collaboration work with the Fischer Lab enables super-resolution microscopy for graphene nanoribbons. [Link]
Congratulations to Meg and our collaborators!
Congratulations to Meg, Michal, Yennie, and Manni!
Congratulations to Meg and Michal for becoming the first graduated Ph.D.'s from the Xu Lab!
Congratulations also to Yennie and Manni's graduation!
We are so proud of you and will miss you all!
Functional super-resolution microscopy for surface chemistry
Our new work in Nature Comm. reveals the fascinating nanoscale structure and composition of surface adlayers. [Link]
See also our other new work in ACS Nano and bioRxiv.
Congratulations to Limin, Michal, Sam, and all!
Our article in Accounts of Chemical Research
We summarize the rationale, design, and results of our recent efforts toward the integration of single-molecule spectroscopy with super-resolution microscopy. [Link]
Thanks go to all past and current lab members, who made this possible.
Resolving the native ultrastructure of the erythrocyte cytoskeleton
Super-resolution microscopy resolves the cytoskeletal meshwork of intact erythrocytes and reveals an 80 nm junction-to-junction distance. [Link]
Congratulations Leiting, Rui, and Wan!
Our integrative approach to single-molecule spectroscopy and microscopy
See our two new JACS papers, where spectrally resolved, functional super-resolution microscopy reveals the nanoscale compositional heterogeneity in live-cell membranes and the multipath reaction pathways of single molecules. Also check out our other new publications. Congratulations to all!
Our collaborative work in PNAS, JCB, and ECR
We've had several collaborative articles published recently in Proceedings of the National Academy of Sciences, Journal of Cell Biology, and Experimental Cell Research!
Congratulations to our students and collaborators!
Our article in JACS
Our article "Spatially resolved in situ reaction dynamics of graphene via optical microscopy" has been published in Journal of the American Chemical Society!
Congratulations Michal, Yunqi, and Wan!
Our article in Chemical Reviews
Our article "Correlative Super-Resolution Microscopy: New Dimensions and New Opportunities" has been published in Chemical Reviews!
Congratulations Meg, Michal, Doory, and Wan! -Great way to start a new year!
Ke received the Packard Fellowship for Science and Engineering!
Congratulations on your recent awards, Ke!
Ke named one of the Talented 12 by Chemical & Engineering News!
Ke received NSF CAREER Award and Beckman Young Investigators Award!
Our new work in Nano Letters!
Our new paper, "Direct Optical Visualization of Graphene and Its Nanoscale Defects on Transparent Substrates", has been published in Nano Letters! [Link]
Congratulations Wan, Seonah, and Michal!
Ke named a Sloan Research Fellow!
Ke has received the Sloan Research Fellowship!
Our new paper in Nature Methods!
Our new paper, “Ultrahigh-throughput single-molecule spectroscopy and spectrally resolved super-resolution microscopy”, has been published in Nature Methods! [Link]
See also news release by LBL: [Link]
Congratulations Zhengyang, Sam, Meg, and Wan!
Our first paper published in Nature Communications!
Our first paper, "Graphene-enabled electron microscopy and correlated super-resolution microscopy of wet cells," has been published in Nature Communications! [Link]
Congratulations Michal, Meg, and Seonah!
Ke named a Pew scholar!
The Pew scholars program supports investigators of outstanding promise in science relevant to the advancement of human health. Congratulations, Ke!
Ke named a Bakar Fellow!
The Bakar Fellows Program supports Berkeley faculty working to apply scientific discoveries to real-world issues in the fields of engineering, computer science, chemistry and biological and physical sciences. Congratulations, Ke!
Ke received an award from the Hellman Fellows Fund
The Hellman Fellows Fund supports the research of promising assistant professors who show capacity for great distinction in their research. Congratulations, Ke!
Michal won the NSF Graduate Research Fellowship
Congratulations Michal on winning the NSF fellowship!
Sam passed his qualifying exam
Congratulations Sam on passing your qualifying exam!
Michal passed his qualifying exam
Congratulations Michal on passing your qualifying exam!
Meg passed her qualifying exam
Congratulations Meg on passing your qualifying exam!
Welcome Dr. Zhengyang Zhang
Our first post-doc has arrived! We're happy to welcome Dr. Zhengyang Zhang to our group and to Berkeley. Zhengyang comes from Nanyang Technological University in Singapore, where he worked on nonlinear optical spectroscopy.
Super-resolution microscope is up and running
The STORM setup in B307B is fully operational and has taken some of its first data. Thanks for all of the hard work setting it up, everyone!
Welcome to Berkeley!
The Ke Xu lab is almost operational after Ke and Michal worked hard setting it up over the summer. Welcome Michal, Sam, and Meg to the group!