The Central California 900 MHz NMR Facility, operated by
Dr. Jeff Pelton and the Wemmer Lab, is a core facility
that helps promote the understanding of the structures and
dynamics of natural products, potential theraputics,
proteins, and nucleic acids at the atomic level.
Instruments include a state-of-the-art 900 MHz
spectrometer equipped with a cryoprobe, and an 800 MHz
spectrometer equipped with a room temperature probe.
Access is available to investigators from QB3 as well as
those at both academic and non-academic institutions on a
A short introductory video to the 900MHz NMR Facility can
be found here.
Click here to see
sample data from the 900 MHz in collaboration with
researchers in the Bay Area.
Rut pathway for degradation of uracil
The system, known as the rut operon, consists of seven
previously uncharacterized proteins which are involved in
the conversion of uracil to ammonia, carbon dioxide,and
3-hydroxypropionic acid. We used mass spectroscopy
and NMR spectroscopy to characterize the product of the
first enzyme in the pathway, Rut A, using uracil as the
starting compound. More information on this project can be