The Wemmer Group maintains a diverse set of research interests centered around our 500, 600, 800 and 900MHz NMR magnets. Click on a subject below to find out more!

NMR Facility

The Central California 900 MHz NMR Facility, operated by Dr. Jeff Pelton and the Wemmer Lab, is a core facility that helps promote the understanding of the structures and dynamics of natural products, potential theraputics, proteins, and nucleic acids at the atomic level. Instruments include a state-of-the-art 900 MHz spectrometer equipped with a cryoprobe, and an 800 MHz spectrometer equipped with a room temperature probe. Access is available to investigators from QB3 as well as those at both academic and non-academic institutions on a recharge basis.

View 900 MHz sample data
Check the 900MHz Calendar
Email Dr. Jeff Pelton to sign-up
(jgpelton at berkeley dot edu)

Bacterial Transcription Initiation
We study the structure and mechanisms of NtrCs from the extreme thermophilic bacteria Aquifex aeolicus using a combination of NMR spectroscopy, X-ray crystallography, Short Angle X-ray Scattering, and other biophysical techniques, in order to better understand the process of bacterial transcription.

sigma We study the structure and function of the sigma54 factor, including the structure of its individual domains, the structural requirements for function, and the DNA-binding activity.

Xenon-based MR Spectroscopy and Imaging

Amyloid Proteins

We employ a combination of solid state NMR (in collaboration with Alex Pines), hydrogen exchange, and limited proteolysis in an effort to obtain detailed structural information on amyloid fibrils and to understand the mechanism of formation.

Our efforts have focused on a model system, a 55mer mutated peptide derived from the Mouse Prion MoPrp 89-143 P101L which has been shown to be infective in transgenic mice.

Energy Biosciences
Plant Cell Wall Structure

This work applies NMR spectroscopy to analysis of feedstock materials, materials after various deconstruction reactions, and model systems for biofuel production. As needed for specific samples and analyses, new NMR experiments are being developed to provide desired information about chemical structures, dynamics, etc. Experiments are done in conjunction other groups in the Energy Biosciences Institute to provide samples from processes and chemistry being studied developed in the Institute.