SiSi Chen

Department: Bioengineering
Former education: BioEngineering, Ph.D UC Berkeley; Electrical Engineering, B.S. MIT
Project title: Surface Patterning to Investigate Cell-Cell Interactions that Regulate Neural Stem Cell Fate Decisions

Project description: Neural stem cells in the subgranular zone of the mammalian hippocampus are found in a complex cellular niche comprised of astrocytes, granule neurons, and endothelial cell-lined blood vessels. However, this niche is difficult to visualize and track in vivo. My aim is to combine high throughput imaging and surface micropatterning to recreate small-scale cellular niches to understand how neighboring cells influence NSC fate at the single-cell level.