Kwon, I. and D.V. Schaffer “Designer Gene Delivery Vectors: Molecular Engineering and Evolution of Adeno-Associated Viral Vectors for Enhanced Gene Transfer.” Pharmaceutical Research (in press).

Ashton, R.S., J. Peltier, C.A. Fasano, A. O'Neill, J. Leonard, S. Temple, D.V. Schaffer (co-corresponding author), and R.S. Kane “High-Throughput Screening of Gene Function in Stem Cells using Clonal Microarrays.” Stem Cells (in press).

Lim, K-I., J-H. Jang, and D.V. Schaffer “Library Selection and Directed Evolution Approaches to Engineering Targeted Viral Vectors.” Biotechnology & Bioengineering (in press). Link to paper

Saha, K., J. Pollock, D.V. Schaffer (co-corresponding author), and K.E. Healy “Designing Synthetic Materials to Control Stem Cell Phenotype.” Current Opinion in Chemical Biology (in press).

Robertson, M.J., P. Gip, and D.V. Schaffer “Neural Stem Cell Engineering: Directed Differentiation of Adult and Embryonic Stem Cells into Neurons.” Frontiers in Bioscience (in press).

Koerber, J.T. and D.V. Schaffer “Transposon-Based Mutagenesis Generates Diverse Adeno-Associated Viral Libraries with Novel Gene Delivery Properties.” Gene Therapy Protocols (in press).

Ho, J.E., E.H. Chung, S. Wall, D.V. Schaffer, and K.E. Healy “Immobilized Sonic Hedgehog N-Terminal Signaling Domain Enhances Differentiation of Bone Marrow-Derived Mesenchymal Stem Cells.” Journal of Biomedical Materials Research Part A (in press). Link to paper

Peltier, J., A. O’Neill, and D.V. Schaffer (2007) “PI3K/Akt and CREB Regulate Adult Neural Hippocampal Progenitor Proliferation and Differentiation.” Developmental Neurobiology, 67:1348-1361. Link to paper

Koerber J.T., Jang J.H., Yu J.H., Kane R.S., and Schaffer D.V. (2007) "Engineering Adeno-Associated Virus for One-Step Purification via Immobilized Metal Affinity Chromatography.
Hum Gene Ther. Apr;18(4):367-78. Link to paper

Greenberg K.P., Geller S.F., Schaffer D.V., and Flannery J.G (2007) "Targeted transgene expression in muller glia of normal and diseased retinas using lentiviral vectors." Invest Ophthalmol Vis Sci. Apr;48(4):1844-52. Link to paper

Leonard J.N., Ferstl P., Delgado A., and Schaffer D.V (2007) "Enhanced preparation of adeno-associated viral vectors by using high hydrostatic pressure to selectively inactivate helper adenovirus." Biotechnol Bioeng. Jan 24. Link to paper

Greenberg K.P., Lee E.S., Schaffer D.V., and J.G. Flannery (2006) “Gene Delivery to the Retina Using Lentiviral Vectors.” Retinal Degenerative Diseases: Advances in Experimental Medicine and Biology, 572: 255-266.

Koerber, J.T. and D.V. Schaffer (2006) “Construction of Diverse Adeno-Associated Viral Libraries for Directed Evolution of Enhanced Gene Delivery Vehicles.” Nature Protocols 1: 701-709. Link to paper

Jang, J-H. and D.V. Schaffer (2006) “Microarraying the Cellular Microenvironment.” Molecular Systems Biology, 2:39. Link to paper

Yu, J.H. and D.V. Schaffer (2006) “High-Throughput, Library-Based Selection of a Murine Leukemia Virus to Infect Nondividing Cells.” J Virol. Sep;80(18):8981-8. Link to paper

Saha, K., Irwin, E.F., Kozhukh, J., Schaffer, D.V. (corresponding author), and K.E. Healy (2007) “Biomimetic Interfacial Interpenetrating Polymer Networks Control Neural Stem Cell Behavior.” J Biomed Mater Res A. Apr;81(1):240-9. Link to paper

Yu, J. and D.V. Schaffer (2006) "Selection of novel vesicular stomatitis virus glycoprotein variants from a peptide insertion library for enhanced purification of retroviral and lentiviral vectors." J. Virol. Apr;80(7):3285-92. Link to paper

Saha, K. and D.V. Schaffer (2006) “Signaling Dynamics in Sonic Hedgehog Tissue Patterning.” Development Mar;133(5):889-900. Link to paper

Maheshri, N., J.T. Koerber, B. Kaspar, and D.V. Schaffer (2006) “Directed Evolution of Adeno-Associated Virus Yields Enhanced Gene Delivery Vectors.” Nature Biotechnology Feb;24(2):198-204. Link to paper

Abranches, E., O'Neill, A., Robertson, M.J., Schaffer, D.V. (corresponding author), and J. Cabral “Development of Quantitative PCR Methods to Analyze Adult Neural Progenitor Cell Culture State.” Biotechnology & Applied Biochemistry, 2006 May;44(Pt 1):1-8. Link to paper

Leonard, J. and D.V. Schaffer “Antiviral RNAi Strategies: Emerging Approaches for Hitting a Moving Target.” Gene Therapy, 2006 Mar;13(6):532-40.Link to paper

Weinberger, L., J. Burnett, J. Toettcher, A.P. Arkin, and D.V. Schaffer "Stochastic gene expression in a lentiviral positive-feedback loop: HIV-1 Tat fluctuations drive phenotypic diversity" Cell, 122:169-182. Link to paper

Agrawal, S. and D.V. Schaffer "In Situ Stem Cell Therapy: Novel Targets, Familiar Challenges." Trends in Biotechnology, 23: 78-83. Link to paper

Yu, J. and D.V. Schaffer "Advanced Targeting Strategies for Murine Retroviral and Adeno-Associated Viral Vectors." Advances in Biochemical Engineering & Biotechnology, 2005;99:147-67. Link to paper

Lee, G., Maheshri, N., Kaspar, B.K., and D.V. Schaffer "PEG Conjugation Modestly Protects Adeno-Associated Viral Vectors Against Antibody Neutralization." Biotechnol Bioeng. 2005 Oct 5;92(1):24-34. Link to paper

Leonard, J. and D.V. Schaffer "Computational Design of RNA Interference Strategies that Resist HIV Escape." Journal of Virology, 79:1645-1654. Link to paper

Schaffer, D.V. and F.H. Gage (2004) "Neurogenesis and Neuroadaptation." Neuromolecular Medicine, 5(1):1-10. Download Paper

Ignowski, J. and D.V. Schaffer (2004) "Kinetic Analysis and Modeling of Firefly Luciferase as a Quantitative Reporter Gene in Live Mammalian Cells." Biotechnology & Bioengineering, 86(7):827-34. Link to paper

O'Neill, A. and D.V. Schaffer "The Biology and Engineering of Stem Cell Control," Biotechnology & Applied Biochemistry, Biotechnology & Applied Biochemistry, 40:5-16. Link to paper

Lai, K., M.J. Robertson, and D.V. Schaffer "The Sonic Hedgehog Signaling System as a Bistable Genetic Switch." Biophysical Journal, 86(5):2748-57. Link to paper

Maheshri, N. and D.V. Schaffer (2003) "Computational and Experimental Analysis of DNA Shuffling." Proceedings of the National Academy of Sciences USA, 100:3071-3076. Link to paper

Weinberger, L., D.V. Schaffer, and A.P. Arkin (2003) "Theoretical Design of a Gene Therapy to prevent AIDS but not HIV-1 infection." Journal of Virology, 77:10028-10036. Link to paper

Lai, K, B.K. Kaspar, F.H. Gage, and D.V. Schaffer (2003) "Sonic Hedgehog Regulates Adult Neural Progenitor Proliferation in Vitro and in Vivo." Nature Neuroscience, 6(1): 21-27. Link to paper

Bonadio, J., Woo, S.L., High, K., Ghivizzani, S.C., and D. Schaffer (2002) "Genetic Approaches to Tissue Engineering: Breakout Session Summary," Annals of the New York Academy of Sciences, 961:71-2. Link to paper

Lee, G. and D.V. Schaffer "Engineering the Surface Properties of Gene Delivery Vectors," invited submission for Synthetic DNA Delivery Systems, eds. Luo, D. and Saltzman, W.M. (in press)

Wiewrodt, W., A.P. Thomas, L. Cipelletti, D.A. Weitz, S.I. Feinstein, D.V. Schaffer, S.M. Albelda, M. Koval, and V.R. Muzykantov (2002) "Size-Dependent Intracellular Immunotargeting into Endothelial Cells via a Surface Adhesion Molecule, PECAM-1," Blood, 99:912-22.

Kaspar, B.K., Vissel, B., Bengoechea, T., Crone, S., Randolph-Moore, L., Muller, R., Brandon, E.P., Schaffer, D., Verma, I.M., Lee, K.F., Heinemann, S.F., and F.H. Gage (2002) "Adeno-associated Virus Effectively Mediates Conditional Gene Modification in the Brain." Proceedings of the National Academy of Sciences USA, 99:2320-5. Link to paper

Kaspar, B.K., D. Schaffer, D. Erickson, L. Hinh, D.A. Peterson, and F.H. Gage (2002) "Targeted Retrograde Gene Delivery for Neuronal Protection." Molecular Therapy, 5:50-6. Link to paper

Mozaffari, M.S. and D.V. Schaffer (2001) "Taurine Modulates Arginine Vasopressin-Mediated Regulation of Renal Function." Journal of Cardiovascular Pharmacology, 37(6): 742-750.

Schaffer, D.V. and D.A. Lauffenburger (2000) "Targeted Synthetic Gene Delivery Vectors." Current Opinions in Molecular Therapeutics, 2: 155-161.

Schaffer, D.V., N. Fidelman, N. Dan, and D.A. Lauffenburger (1999) "Vector Unpackaging as a Potential Barrier for Receptor-Mediated Polyplex Gene Delivery." Biotechnology & Bioengineering, 67: 598-606. Link to paper

Lauffenburger, D.A. and D.V. Schaffer (1999) "The Matrix Delivers." Nature Medicine, 5: 733-734.

Schaffer, D.V. and D.A. Lauffenburger (1998) "Optimization of Cell Surface Binding Enhances Efficiency and Specificity of Molecular Conjugate Gene Delivery." Journal of Biological Chemistry , 273:28004-28009. Link to paper

Schaffer, D.V., R.L. Neve, and D.A. Lauffenburger (1996) "Use of Green Fluorescent Protein as a Reporter of Epidermal Growth Factor Receptor-Mediated Gene Delivery." Tissue Engineering, 3: 53-63.

Gramer, M.J., D.V. Schaffer, M.B. Sliwkowski, and C.F. Goochee (1994) "Purification and Characterization of an a-L-Fucosidase from Chinese Hamster Ovary Cell Culture Supernatant." Glycobiology, 4:611-616.