Mathies' early work at Berkeley focused on the use of resonance Raman and time resolved optical spectroscopy to elucidate the structure and reaction dynamics of energy and information transducing photoactive proteins. Mathies' more recent work in the area of biotechnology and the Human Genome Project has led to the development of new high-speed, high-throughput DNA analysis technologies such as capillary array electrophoresis and energy transfer fluorescent dye labels for DNA sequencing and analysis.Prof. Mathies founded The Center for Analytical Biotechnology. He is author of over 340 publications and 25 patents on photochemistry, photobiology, bioanalytical chemistry and genome analysis technology. Prof. Mathies' office is in 307 Lewis Hall; he may be contacted by phone at (510)-642-3599 or by email at .
For the departmental page click here.
Selected Recent Publications:
240. Lagally, E. T., Medintz, I. and Mathies, R. A. Single
Molecule DNA Amplification and Analysis in an Integrated Microfluidic
Device, Anal. Chem. 73, 565-570 (2001). pdf
244. Berti, L., Xie, J., Medintz, I. L., Glazer, A. N. and Mathies, R.
A. Energy Transfer Cassettes for Facile Labeling of Sequencing and PCR
Primers, Analytical Biochemistry 292, 188-197
(2001). pdf
247. Medintz, I. L., Berti, L., Emrich, C. A., Tom, J., Scherer, J. R. and Mathies, R. A. Genotyping Energy-Transfer Cassette Labeled Short Tandem Repeat Amplicons with Capillary Electrophoresis Microchannel Plates, Clinical Chemistry 47, 1614-1621 (2001). pdf
250. Kim, J. E., Tauber, M. J. and Mathies, R. A. Wavelength Dependent Cis-Trans Isomerization in Vision, Biochemistry 40, 13774-13778 (2001). pdf
252. Tauber, M. J. and Mathies, R. A. Fluorescence and Resonance Raman Spectra of the Aqueous Solvated Electron, J. Phys. Chem. A, 105, 10952-10960 (2000). pdf
257. Paegel, B. M., Emrich, C. A., Wedemayer, G. J., Scherer,
J. R. and Mathies, R. A., High-Throughput DNA Sequencing with a 96-Lane
Capillary Array Electrophoresis Bioprocessor, PNAS, 99,
574-579 (2002). pdf
258. Lagally, E. T., Emrich, C. A. and Mathies, R. A. Fully Integrated
PCR-Capillary Electrophoresis Microsystem for DNA Analysis. Lab-on-A-Chip,
1 (2) 102-107 (2001). pdf
259. Tauber, M. J. and Mathies, R. A. Resonance Raman Spectra and Vibronic Analysis of the Aqueous Solvated Electron, Chemical Physics Letters, 354, 518-526 (2002). pdf
260. Pan, D., Ganim, Kim, J. E. and Mathies, R. A. Time-resolved Resonance Raman Analysis of Chromophore Structural Changes in the Formation and Decay of Rhodopsin’s BSI Intermediate, J. Amer. Chem. Soc., 124, 4857-4864 (2002). pdf
262. Yan, E. C. Y., Kazmi, M. A., De, S., Chang, B. S. W., Seibert, C., Marin, E. P., Mathies, R. A. and Sakmar, T. P. Function of Extracellular Loop 2 in Rhodopsin. Glutamic Acid 181 Modulates Stability and Absorption Wavelength of Metarhodopsin II, Biochemistry, 41, 3620-3627 (2002). pdf
311. Skelley, A. M., Scherer, J. R., Aubrey, Grover, W. H., A. D., Ivester, R. H. C., Ehrenfreund, P., Grunthaner, F. G., Bada, J. L. and Mathies, R. A. Development and Evaluation of a Microdevice for Amino Acid Biomarker Detection and Analysis on Mars, Proc. Natl. Acad. Sci. U.S.A., 102, 1041-1046 (2005).pdf
318. Grover, W. H. and Mathies, R. A. An Integrated Microfluidic Processor for Single Nucleotide Polymorphism-Based DNA Computing, Lab-on-a-Chip, 5, 1033-1040 (2005). pdf
319. Chan, E. M., Alivisatos, A. P. and Mathies, R. A. High-Temperature Microfluidic Synthesis of CdSe Nanocrystals in Nanoliter Droplets, J. Am. Chem. Soc., 127, 13854-13861 (2005). pdf
320. Toriello, N. M., Douglas, E. S. and Mathies, R. A. Microfluidic Device for Electric-Field Driven Single-Cell Capture and Activation, Analytical Chemistry, 77, 6935-6941 (2005). pdf
326. Kukura, P., McCamant, D. W., Yoon, S., Wandschneider, D. B. and Mathies, R. A. Structural Observation of the Primary Isomerization in Vision with Femtosecond Stimulated Raman, Science, 310, 1006-1009 (2005). pdf
328. Blazej, R. G., Kumaresan, P. and Mathies, R. A. Microfabricated bioprocessor for integrated nanoliter-scale Sanger DNA sequencing, PNAS 103, 7240-7245 (2006). pdf
