Dr. Nadine Schwierz
Emmy Noether research group leader
Institute of Biophysics
Department of Theoretical Biophysics
My research addresses the theoretical description of biological soft matter
systems using methods of statistical physics and computer simulations. The
research focuses on quantitatively describing the interactions between
biomolecules and characterizing the influence of ions and
water molecules. The overarching goal of my research is to develop a detailed
understanding at the molecular level in order to contribute to advances in new
technologies and modern medicine.
To achieve these goals, a broad spectrum of
theoretical methods and state of the art computer simulations is used. Special
emphasis is placed on the combination of the results from atomistic molecular
dynamics simulations with continuum methods and coarse-grained descriptions,
thereby providing a connection between microscopic details and macroscopic,
experimentally accessible properties. Special areas of research include the
interaction of polypeptides with functional surface groups and lipid bilayers,
structure formation and growth of amyloid fibrils, ion specific phenomena, and
microfluidics for energy conversion and power generation.
The work of the
newly established Emmy Noether group will focus on the role of metal cations in
RNA folding and function.
S. Mamatkulov and N. Schwierz
Force fields for monovalent and divalent metal cations in TIP3P water
based on thermodynamic and kinetic properties.
J. Phys.Chem.,148, 074504, 2018 (doi)
N. Schwierz, D. Horinek, U. Sivan and R. R. Netz.
Series - the Rule rather than the Exception.
Curr. Opin. Colloid Interface Sci.,23,
10-18, 2016 (doi)
N. Schwierz, C. V. Frost, P. L. Geissler and M. Zacharias.
Dynamics of Seeded Aβ40-Fibril
Growth from Atomistic Molecular Dynamics Simulations:
Kinetic Trapping and Reduced Water
Mobility in the Locking Step.
J. Am. Chem.
Soc., 138(2), 527-539, 2016 (doi)
D. Horinek, S. Liese, T. Pirzer, B. N. Balzer, T. Hugel and R. R. Netz.
On the Relationship between Peptide
Adsorption Resistance and Surface Contact Angle:
A Combined Experimental and
Simulation Single-molecule Study.
J. Am. Chem.
Soc. 134(48), 19628-19638, 2012 (doi)
Nadine Schwierz ~