~ Theoretical Biophysics ~
TOC

Personal Information

Dr. Nadine Schwierz
Emmy Noether research group leader
Max Planck Institute of Biophysics
Department of Theoretical Biophysics


Research Interest

My research addresses the theoretical description of biological soft matter systems using methods of statistical physics and computer simulations. The research focuses on quantitatively describing the interactions between biomolecules and characterizing the influence of ions and water molecules. The overarching goal of my research is to develop a detailed understanding at the molecular level in order to contribute to advances in new technologies and modern medicine.
To achieve these goals, a broad spectrum of theoretical methods and state of the art computer simulations is used. Special emphasis is placed on the combination of the results from atomistic molecular dynamics simulations with continuum methods and coarse-grained descriptions, thereby providing a connection between microscopic details and macroscopic, experimentally accessible properties. Special areas of research include the interaction of polypeptides with functional surface groups and lipid bilayers, structure formation and growth of amyloid fibrils, ion specific phenomena, and microfluidics for energy conversion and power generation.
The work of the newly established Emmy Noether group will focus on the role of metal cations in RNA folding and function.

Selected Publications

S. Mamatkulov and N. Schwierz
Force fields for monovalent and divalent metal cations in TIP3P water
based on thermodynamic and kinetic properties.

J. Phys.Chem.,148, 074504, 2018 (doi)

N. Schwierz, D. Horinek, U. Sivan and R. R. Netz.
Reversed Hofmeister Series - the Rule rather than the Exception.
Curr. Opin. Colloid Interface Sci.,23, 10-18, 2016 (doi)

N. Schwierz, C. V. Frost, P. L. Geissler and M. Zacharias.
Dynamics of Seeded Aβ40-Fibril Growth from Atomistic Molecular Dynamics Simulations:
Kinetic Trapping and Reduced Water Mobility in the Locking Step.
J. Am. Chem. Soc., 138(2), 527-539, 2016 (doi)

N. Schwierz, D. Horinek, S. Liese, T. Pirzer, B. N. Balzer, T. Hugel and R. R. Netz.
On the Relationship between Peptide Adsorption Resistance and Surface Contact Angle:
A Combined Experimental and Simulation Single-molecule Study.

J. Am. Chem. Soc. 134(48), 19628-19638, 2012 (doi)
 ~ Nadine Schwierz ~