2003

1. Pi, N., Leary, J.A.; “Determination of Enzyme Substrate Specificity using a Multiplex ESI-MS Assay”, Submitted to J. Amer. Soc. Mass Spectrom.

2. Leavell, M.D., Petzold, C.J., Leary, J.A., “Enrichment, Screening, and Identification of Phosphorylated Metabolites in Biological Mixtures using Mass Spectrometry” Submitted to Anal. Chem.

3. Pi, N., Yu, Y., Mougous, J.D., Leary, J.A., “Observation of a Hybrid Random Ping-Pong Mechanism of Catalysis for NodST: A Mass Spectrometry Approach”, Submitted to J. Amer. Chem. Soc.

4. Gao, H., Petzold, C. J., Leavell, M.D., Leary, J.A. “Investigation of Ion-Molecule Reactions as a Quantification Method for Phosphorylated Diastereomers: An FT-ICR Approach” J. Amer. Soc. Mass Spectrom, in press.

5. Saad, O., and Leary, J.A. “Compositional Analysis and Quantification of Heparin and Heparan Sulfate by Electrospray Ionization Mass Spectrometry” Anal. Chem. , 2003, 75, 2985.

6. Converse, S.E., Mougous, J.D., Leavell, M.D. , Leary, J.A., Bertozzi, C.R., Cox, J.S., “MmpL8 is required for sulfolipid biosynthesis and M. tuberculosis virulence” Proc. Natl. Acad. Sci., 2003, 100, 6121.

7. Leavell, M. and Leary, J.A. “Probing Isomeric Differences of Phosphorylated Carbohydrates Through the Use of Ion/Molecule Reactions and FTICR” J. Amer. Soc. Mass Spectrom. , 2003, 14, 323.

8. Gao, H. and Leary, J.A. “Multiplex Inhibitor Screening and Kinetic Constant Determinations for Yeast Hexokinase using Mass Spectrometry based Assays” J. Amer. Soc. Mass Spectrom., 2003, 14(3), 173.

9. Leavell, M., Kruppa, G.H., Leary, J. “ Determination of Phosphate Position in Hexose Monosaccharides Using an FTICR Mass Spectrometer: Ion/molecule reactions, Labeling Studies and Dissociation Mechanisms” Int. J. Mass Spec., 2003, 222, 135.

2002

10. Pi, N., Armstrong, J.I., Bertozzi, C.R., Leary, J.A. “Kinetic Analysis of NodST Sulfotransferase using an Electrospray Ionization Mass Spectrometry Assay”, Biochemistry, 2002, 41, 13283.

11. Leavell, M., Magous, J., Leigh, C., Bertozzi*, C.R., Leary*, J.A. “Exploiting the sulfate assimilation pathway in mycobacteria; a method for discovering and removing sulfated molecules.” Proc. Natl. Acad. Sci., 2002, 99, #26, 17037.


12. Leavell, M.D., Kruppa, G.H., Leary, J. A., “ Analysis of Phosphate Position in Hexose Monosaccharides Using Ion-Molecule Reactions and SORI-CID on an FT-ICR Mass Spectrometer,” Anal. Chem., 2002, 74, 2608.

13. Desaire, H., Leavell, M. D., Leary, J. A.; “Solvent Effects in Tandem Mass Spectrometry:Mechanistic Studies Indicate How a Change in pH Can Dramatically Alter CID Spectra,” J. Org. Chem., 2002, 67, 3693.

14. Leavell, M. D., Leary, J. A; “Mass Spectrometric Strategy for the Characterization of LOS from Neisseria gonorrhoeae 302 using FTICR,” J. Amer. Soc. Mass Spectrom., 2002, 13, 571.

15. Leavell, M. D., Gaucher, S. P., Taraszka, J. A., Clemmer, D. E., Leary, J. A.; “Conformational Studies of Zn-Ligand-Hexose Diastereomers Using Ion Mobility Measurements and Density Functional Calculations,” J. Amer. Soc. Mass Spectrom., 2002, 13, 284.

2001

16. Ge, X., Sirich, T., Beyer, M., Desaire, H., Leary, J. A.; "A Novel Strategy for the Determination of Enzyme Kinetics Using Electrospray Ionization with Ion Trap Mass Spectrometry," Anal. Chem., 2001, 73, 5078.

17. Armstrong, J. I., Ge, X., Verdugo, D. E., Winans, K.A., Leary, J. A., Bertozzi, C. R.; "A Library Approach to the Generation of Bisubstrate Analog Sulfotransferase Inhibitors," Org. Lett., 2001, v3, n17, 2657.

18. Desaire, H., Leary, J. A.; " The Effect of Coordination Number and Ligand Size on the Gas Phase Dissociation and Stereochemical Differentiation of Co-Coordinated Monosaccharides," Int. J. Mass Spec.,2001, 209, 171.

19. Schilling, B., Good, S., Samuels, N. M, Gaucher, S. P., Leary, J. A., Bertozzi, C. R., Gibson, B. W.; "Biosynthesis of Sialylated Lipooligosaccharides in Haemophilus ducreyi Is Dependent on Exogenous Sialic Acid and Not Mannosamine," Biochemistry, 2001, 40, 12666.

20. Desaire, H., Sirich, T., Leary, J. A.; "Evidence of Block and Randomly Sequenced Chondroitin Polysaccharides: Sequential Enzymatic Digestion and Quantification Using Ion Trap Tandem Mass Spectromety," Anal. Chem., 2001, v73, n15, 3513.

21. Caulder, D. L., Brückner C., Powers R. E., König, S., Parac, T. N., Leary, J. A., and Raymond, K. N.; “Design, Formation and Properties of Tetrahedral M4L4 and M4K6 Supramolecular Clusters,” J. Am. Chem. Soc., 2001, v123, n37, 8923.

22. Verdugo, D. E., Cancilla, M. T. Ge, X, Gray, N. S., Chang, Y.T., Schultz, P.G., Leary, J. A., Bertozzi, C. R.; "Discovery of Estrogen Sulfotransferase Inhibitors from a Purine Library," J. Med. Chem., 2001, v44, n17, 2683.

23. Desaire, H., Beyer, M. B., Leary, J. A.; “Molecular Orbital Considerations in Probing the Stereoselective Dissociations of Cobalt-Coordinated Hexosamine Monosaccharides,” J. Amer. Soc. Mass Spec, 2001, 12, 517.

24. Leavell, M. D., Leary, J. A.; “Stabilization and Linkage Analysis of Metal-ligated Sialic Acid Containing Oligosaccharides,” J. Amer. Soc. Mass Spec., 2001, 12, 528.

25. Ziegler, M., Miranda, J., Andersen, U. N., Johnson, D. W., Leary, J. A., Raymond, K. N.; “Combinatorial Libraries of Metal-Ligand Assemblies with An Encapsulated Guest Molecule,” Angewandte, Chem., 2001, 40 (4), 733.

26. Leavell, M. D., Leary, J. A.; “Dissociation Mechanisms for Metal N-Glycosides of N-Acetyl Neuraminic Acid,” Int. J. of Mass Spec. 2001, 204, 185.

2000

27. Gaucher, S. P., Cancilla, M. T., Phillips, N. J., Gibson, B. W., Leary, J. A.; "Mass Spectral Characterization of Lipooligosaccharides from Haemophilus influenzae 2019," Biochemistry, 2000, 39(40), 12406.

28. Desaire, H., Leary J. A.; "Utilization of MS3 spectra for the Multicomponent Quantification of Diastereomeric N-Acetylhexosamines," J. Amer. Soc. Mass Spectrom., 2000, 11, 1086.

29. Cancilla, M. T., Leavell, M. D., Chow, J. and Leary, J. A.; “Mass Spectrometry and Immobilized Enzymes for the Screening of Inhibitor Libraries,” PNAS, 2000, 97, 12008.

30. Desaire, H., Leary, J. A.; "Detection and Quantification of the Sulfated Disaccharides in Chondroitin Sulfate by Electrospray Tandem Mass Spectrometry,” J. Amer. Soc. Mass Spectrom., 2000, 11, 916.

31. Beyer, M. K., Leary, J.A.; "Comment on 'Energy-Resolved Collision-Induced Dissociation of Fe_2(CO)_y^+ (y=1-9)'," J. Phys. Chem. A, 2000, 104, 9395.

32. Cancilla, M. T., Gaucher, S. P., Desaire, H., Leary, J. A.; “Combined Partial Acid Hydrolysis and Electrospray Ionization-Mass Spectrometry for the Structural Determination of Oligosaccharides,” Anal. Chem., 2000, 72, 2901.

33. Gaucher, S. P., Morrow, J., Leary, J. A.; “ STAT: A Saccharide Topology Analysis Tool Used In Combination with Mass Spectrometry,” Anal. Chem., 2000, 72, 2331. (Accelerated Article).

34. Gaucher, S. P., Leary, J. A.; “Influence of Metal Ion and Coordination Geometry on the Gas Phase Dissociation and Stereochemical Differentiation of N-glycosides,” Int. J. Mass Spec., 2000, 197, 139.

1999

35. Smith, G., Leary, J. A.; “Synthesis and Analysis of ESI-Generated Five-Coordinate Diastereomeric Ni N-Glycoside Complexes using a Quadrupole Ion Trap Mass Spectrometer,” Int. J. Mass Spec., 1999, 193, 153.

36. Desaire, H., Leary, J. A.; “Multicomponent Quantification of Diastereomeric Hexosamine Monosaccharides using Ion Trap Tandem Mass Spectrometry,” Anal. Chem., 1999, 71, 4142.

37. Gaucher, S. P., Pedersen, S. F., Leary, J. A.; "Stereospecific Synthesis of N-Glycoside Ligands using Diethylenetriamine," J. Org. Chem., 1999, 64, 4012.

38. Desaire, H., Leary, J. A.; "Differentiation of Diastereomeric N-Acetyl Hexosamine Monosaccharides Using Ion Trap Mass Spectrometry," Anal. Chem., 1999, 71, 1997.

39. Andersen, U. N., König, S., Freitas, M. A., Marshall, A. G., Leary, J. A.; "Single Crystal Characterization of a Cubic Prussian Blue Co8(TACN)8(CN)8 Cluster by Ion Trap and FT-ICR Mass Spectrometry using Micro-Electrospray Ionization," J. Amer. Soc. Mass Spectrom., 1998, 10, 352.

40. Smith, G., Kaffashan, A., Leary, J. A.; "Influence of Coordination Number and Ligand Size on the Dissociation Mechanisms of Transition Metal-Monosaccharide Complexes," Int. J. Mass Spectrom. Ion Proc., 1999, 182/183, 299.

41. Gaucher, S. P., Leary, J. A.; "Determining Anomericity of the Glycosidic Bond in Zn(II)- Diethylentriamine-Disaccharide Complexes Using MSn in a Quadrupole Ion Trap," J. Amer. Soc. Mass Spectrom., 1999, 10, 269.

1998

42. Smith, G., Leary, J. A.; "Mechanistic Studies of Diastereomeric Nickel (II) N-Glycoside Complexes Using Tandem Mass Spectrometry," J. Amer. Chem. Soc., 1998, 120, 13046.

43. Kriesel, J., König, S., Freitas, M., Marshall, A. G., Leary, J. A., Tilley, T. D.; "The Synthesis of Highly Charged Organometallic Dendrimers and their Characterization by Electrospray Mass Spectrometry and Single Crystal X-ray Diffraction," J. Amer. Chem. Soc., 1998, 120, 12207.

44. König, S., Bruckner, C., Raymond, K. N., Leary, J. A.; "ESI-ITMS of a Tetrahedral Supramolecular Ti4L4 Cluster," J. Amer. Soc. Mass Spectrom, 1998, 9, 1099.

45. König, S., Leary, J. A.; "Evidence for Linkage Position Determination in Cobalt Coordinated Pentasaccharides using Ion Trap Mass Spectrometry," J. Amer. Soc. Mass Spectrom, 1998, 9, 1125.

46. Gaucher, S. P., Leary, J. A.; "Stereochemical differentiation of Mannose, glucose, galactose, talose using metal coordinated ligands and ion trap mass spectrometry," Anal. Chem., 1998, 70, 3009.

1997

47. Kohler, M., Leary, J. A.; "Gas Phase Reactions of Doubly Charged Alkaline Earth and Transition Metal Complexes of Acetonitrile, Pyridine, and Methanol Generated by Electrospray Ionization," J. Amer. Soc. Mass Spectrom., 1997, 8, 1124.

48. Smith, G., Pedersen, S. F., Leary, J. A.; "Stereoselective Beta-Hydrogen Elimination from Nickel (II)N-Glycoside Complexes," J. Org. Chem., 1997, 62, 2152.

49. Sible, E., Brimmer, S., Leary, J. A.; "Interaction of First Row Transition Metals with a1-3, a1-6 Mannotriose and Conserved Trimannosyl Core Oligosaccharides: A Comparative ESI Study of Doubly and Singly Charged Complexes," J. Amer. Soc. Mass Spectrom., 1997, 8, 32.

50. Kohler, M., Leary, J. A.; "Gas Phase Reactions of Doubly Charged Alkaline Earth and Transition Metal (II)-Ligand Complexes Generated by Electrospray Ionization," IJMSIP, 1997, 162, 17.

51. Zheng, Y. J., Ornstein, R. L., Leary, J. A.; "A Density Functional Theory Investigation of Metal Ion Binding Sites in Monosaccharides," THEOCHEM, 1997, 389, 233.

1996

52. Smith, G., Leary, J. A.; "Differentiation of Sterochemistry of Glycosidic Bond Configuration: Tandem Mass Spectrometry of Diastereomeric Cobalt-Glucosyl-Glucose Disaccharide Complexes," J. Amer. Soc. Mass Spectrom., 1996, 7, 953.

53. Smith, G., Leary, J. A.; “Differentiation of Diastereomeric Nickel (II) B-Glycoside Complexes Using Tandem Mass Sprectrometry and Kinetic Energy Release Measurements” J. Amer. Chem. Soc., 1996, 118, 3293.

1995

54. Kohler, M., Leary, J. A.; "LC-MS/MS of Carbohydrates with Post Column Addition of Metal Salts using a Triaxial Electrospray Probe," Anal. Chem, 1995, 67, 3501.

1994

55. Telford, J. R., Leary, J. A.; Tunstad, L., Byers, B. R., Raymond, K. N.; "Amonabactin: Characterization of a Series of Siderophores from Aeromonas hydrophila," J. Amer. Chem. Soc., 1994, 116, 4499.

56. Dang, T. T., Pedersen, S. F., Leary, J. A.; "Chiral Recogniation in the Gas Phase: Mass Spectrometric Studies of Diastereomeric Cobalt Complexes," J. Amer. Soc. Mass Spec., 1994, 5, 452.

1993

57. Fura, A., Leary, J. A.; "Differentiation of Ca2+- and Mg2+-Coordinated Trisaccharide Isomers: An Electrospray Ionization and Tandem Mass Spectrometry Study," Anal. Chem., 1993, 65, 2805.

58. Zheng, Y. J., and Leary, J. A.; "Mechanism of Gas Phase Aldose-Ketose Isomerization: A Study Using Tandem Mass Spectrometry and Theoretical Calculations," J. Amer. Soc. Mass Spec., 1993, 4, 943.

1992

59. Swanson, R, Zhou, J., Leary, J. A., Williams, T., de Lorimier, R., .Bryant, D., Glazer, A. N.; "Characterization of Phycocyanin Produced by cpcE and cpcF Mutants and Identification of an Intergenic Suppressor of the Defect in Bilin Attachment," J. Biol. Chem., 1992, 23, 16146.

60. Staempfli, A., Zhou, Z., Leary, J. A.; "Gas Phase Dissociation Mechanisms of Dilithiated Disaccharides: Tandem Mass Spectrometry and Semiempirical Calculations," J. Org. Chem., 1992, 57, 3590.

1991

61. Hofmeister, G., Leary, J. A.; "Chiral Recognition of Lithium-Coordinated Diols using Tandem Mass Spectrometry," Org. Mass Spectrom, 1991, 26, 811.

62. Hofmeister, G., Zhou, Z., Leary, J. A.; "Linkage Position Determination in Lithiated Disaccharides: Tandem Mass Spectrometry and Semiempirical Calculations," J. Am. Chem. Soc., .1991, 113, 5964.

1990

63. Zhou, Z., Ogden, S., Leary, J. A.; "Linkage Position Determination in Oliogosaccharides: MS/MS Study of Lithium Cationized Carbohydrates," J. Org. Chem., 1990, 55, 5444.

64. Bott, G., Ogden, S., and Leary, J.A.; "Collision Energy Ramp: Modification to an RF-only Quadrupole Collision Cell," Rapid Commun. in Mass Spectrometry, 1990, 4(9), 341.

65. Leary, J. A., Zhou, Z., Ogden, S. and Williams, T. D.; "Gas Phase Investigation of Lithiated Peptide Adducts: Tandem Mass Spectrometry and Semiempirical Studies," J. Am. Soc. Mass Spec., 1990, 1(6), 473.

66. Hofmeister, G. E., Alvarado, E., Leary, J. A., Yoon, D. I., and Pedersen, S. F.; "Synthesis and Characterization of Dimetallacalix[8]arene Complexes," J. Am. Chem. Soc., 1990, 112, 8843.

67. Branan, D.M., Hoffman, N. W., McElroy, E. A., Ramage, D. L., Robbins, M. J., Eyler, J. R., Watson, C. H., deFur, P. and Leary, J. A.; "A Comparison of Laser Desorption and Fast Atom Bombardment Mass Spectra of a Series of Rh(PPh3)2(CO)Y Complexes," Inorg. Chem., 1990, 29, 1915.

68. Arrendale, R.F., Severson, R. F., Sisson, V. A., Costello, C. E., Leary, J. A., Himmelsbach, D. S., and van Halbeek, H.; "Characterization of the Sucrose Ester Fraction from Nicotiana Glutinosa," J. Agric. and Food Chem., 1990, 38, 75.

1989

69. Leary, J. A., and Pedersen, S. F.; "A Reliable Method for Fast Atom Bombardment Mass Spectrometric Analysis of a-Aryl-1, 2-Diols. Formation of Lithium-Diol Adducts," J. Org. Chem., 1989, 54, 5650.

70. Leary, J. A., Williams, T. D., and Bott, G.; "Strategy for Sequencing Peptides as Mono- and Dilithiated Adducts Using a Hybrid Tandem Mass Spectrometer," Rapid Communications in Mass Spectrometry, 1989, 3, 192.

1988

71. Thomas, B. J., Mitchel, J. F., Leary, J. A., and Theopold, K. H., "Synthesis and Structure Determination of [Cp*4Cr4(m-F)5Cl2]PF6. A Tetranuclear Chromium Complex Formed by Floride Abstraction From Hexafloraphosphate," J. Organomet. Chem., 1988, 348, 333.

1987

72. Leary, J. A., et. al. "Chemical and Toxicological Characterization of Residential Oil Burner Emissions 1," Environmental Health Perspectives, 1987, 73, 223.

1986

73. Klotz, A. V., Leary, J. A., and Glazer, A. N.; "Post-translational Methylation of Asparaginyl Residues. Identification of b-71 g-N-Methylasparagine in Allophycocyanin," J. Biol. Chem., 1986, 216(34), 15891.

74. Furlong, S. T., Leary, J. A., Costello, C. E., and Davidowicz, E. A.; "Isolation and Identification of 1(3), 2-diacylglycerol-(3)-0-4'-(N,N,N-trimethyl)homoserine From the Soil Amoeba, Acanthamoeba Castellanii," J. Lipid Research, 1986, 27, 1182.

1983

75. Leary, J. A., Lafleur, A. L., Liber, H. L., and Biemann, K.; "Chemical and Toxicologic Characterization of Fossil Fuel Combustion Product Phenalenone," Anal. Chem., 1983, 55, 758.

1982

76. Leary, J.A., Lafleur, A. L., Peters, W. A., Kruzel, E. L., Longwell, J. P., and Biemann, K.; "Chemical characterization of Domestic Fuel Oil and Its Combustion Products," Polycyclic Aromatic Hydrocarbons, 7th International Symposium, Battelle Press, 1982, 799.

1981

77. Prado, G., Westmoreland, P. R., Andon, B. M., Leary, J. A., Biemann, K. and Thilly, W. G., "Formation of Polycyclic Aromatic Hydrocarbons in Premixed Flames. Chemical Analysis and Mutagenicity," Polynuclear Aromatic Hydrocarbons, 5th International Symposium, Battelle Press, 1981, 189.

1979

78. Balkon, J. and Leary, J.A. "An initial Report on a Comprehensive, Quantitative Screening Procedure for Volatile Compounds of Forensic and Environmental Interest in Human Bile Fluids by GCMS," J. Anal. Tox., 1979, 3, 213.


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