Publications

  1. A.M. Weeks and M.C.Y. Chang, "Catalytic control of enzymatic fluorine specificity", Proc. Natl. Acad. Sci. U.S.A. 2012, 109, 19667-19672. [pdf][SI][C & E News]




  2. M.E. Brown, T. Barros, and M.C.Y. Chang, "Identification and characterization of a multi-functional dye peroxidase from a lignin-reactive bacterium", ACS Chem. Biol. 2012, 7, 2074-2081. [pdf][SI]




  3. B.B. Bond-Watts, A.M. Weeks, and M.C.Y. Chang, "Biochemical and structural characterization of the trans-enoyl-CoA reductase from Treponema denticola", Biochemistry 2012, 51, 6827-6837. [pdf][SI]




  4. M.C. Walker, Miao Wen, A.M. Weeks, and M.C.Y. Chang, "Temporal and fluoride control of secondary metabolism regulates cellular organofluorine biosynthesis", ACS Chem. Biol. 2012, 7, 1576-1585. [pdf][SI]




  5. M.E. Brown, M.C. Walker, T.G. Nakashige, A.T. Iavarone, and M.C.Y. Chang, "Discovery and characterization of heme enzymes from unsequenced bacteria: Application to microbial lignin degradation", J. Am. Chem. Soc. 2011, 133, 18006-18009. [pdf][SI][JACS cover]




  6. A.M. Weeks and M.C.Y. Chang, "Constructing de novo biosynthetic pathways for chemical synthesis inside living cells", Biochemistry 2011, 50, 5404-5418. [pdf]




  7. B.B. Bond-Watts, R.J. Bellerose, and M.C.Y. Chang, "Enzyme mechanism and a kinetic control element for designing synthetic biofuel pathways", Nat. Chem. Biol. 2011, 7, 222-227. [pdf][SI][News & Views][MSNBC News][UCB News][C & E News][German Public Radio interview][SETI Big Picture Science Podcast]




  8. A.M. Weeks, S.M. Coyle, M. Jinek, J.A. Doudna, and M.C.Y. Chang, "Structural and biochemical studies of a fluoroacetyl-CoA thioesterase reveal a molecular basis for fluorine selectivity", Biochemistry 2010, 49, 9269-9279. [pdf][SI]




  9. M.C.Y. Chang, "Harnessing energy from plant biomass", Curr. Opin. Chem. Biol. 2007, 11, 677-684. [pdf]


  10. J.A. Dietrich, Y. Yoshikuni, K.J. Fisher, F.X. Woolard, D. Ockney, D.J. McPhee, N.S. Nenninger, M.C.Y. Chang, D. Baker, and J.D. Keasling, "A novel semi-biosynthetic route for artemisinin production using engineered substrate-promiscuous P450-BM3", ACS Chem. Biol. 2009, 4, 261-267.

  11. M.C.Y. Chang, R.A. Eachus, W. Trieu, D.-K. Ro, and J.D. Keasling, "Engineering Escherichia coli for production of functionalized terpenoids using plant P450s", Nat. Chem. Biol. 2007, 3, 274-277.

  12. M.C.Y. Chang and J.D. Keasling, "Production of isoprenoid pharmaceuticals by engineered microbes", Nat. Chem. Biol. 2006, 2, 674-681.

  13. J.D. Newman, J. Marshall, M.C.Y. Chang, F. Nowroozi, E.M. Paradise, D.P. Pitera, K.L. Newman, and J.D. Keasling, "High-level production of amorpha-4,11-diene in a two-phase partitioning bioreactor of metabolically-engineered Escherichia colii", Biotechnol. Bioeng. 2006, 95, 684-691.

  14. D.-K. Ro, E.M. Paradise, M. Ouellet, K.J. Fisher, K.L. Newman, J.M. Ndungu, K.A. Ho, R.A. Eachus, T. Ham, J. Kirby, M.C.Y. Chang, S.T. Withers, Y. Shiba, R. Sarpong, and J.D. Keasling, "Production of the antimalarial drug precursor artemisinic acid in engineered yeast", Nature 2006, 440, 940-943.

  15. M.C.Y. Chang, C.S. Yee, D.G. Nocera, and J. Stubbe, "Site-specific replacement of a conserved tyrosine in ribonucleotide reductase with an aniline amino acid: A mechanistic probe for redox-active tyrosines", J. Am. Chem. Soc. 2004, 126, 16702-16703.

  16. M.C.Y. Chang, A. Pralle, E.Y. Isacoff, and C.J. Chang, "A selective, cell-permeable optical probe for hydrogen peroxide in living cells", J. Am. Chem. Soc. 2004, 126, 15392-15393.

  17. M.C.Y. Chang, C.S. Yee, J. Stubbe, and D.G. Nocera, "Turning on ribonucleotide reductase by light-initiated radical generation", Proc. Natl. Acad. Sci. U.S.A. 2004, 101, 6882-6887.

  18. C.J. Chang, M.C.Y. Chang, N.H. Damrauer, and D.G. Nocera, "Proton-coupled electron transfer: A unifying mechanism for biological charge transport, amino acid radical initiation and propagation, and bond making/breaking reactions of water and oxygen", Biochim. Biophys. Acta 2004, 1655, 13-28.

  19. C.S. Yee, M.S. Seyedsayamdost, M.C.Y. Chang, D.G. Nocera, and J. Stubbe, "Generation of the R2 subunit of ribonucleotide reductase by intein chemistry: Insertion of 3-nitrotyrosine at residue 356 as a probe of the radical initiation process", Biochemistry 2003, 42, 14541-14552.

  20. C.S. Yee, M.C.Y. Chang, J. Ge, D.G. Nocera, and J. Stubbe, "2,3-Difluorotyrosine at position 356 of ribonucleotide reductase R2: A probe of long-range proton-coupled electron transfer", J. Am. Chem. Soc. 2003, 125, 10506-10507.

  21. J. Stubbe, D.G. Nocera, C.S. Yee, and M.C.Y. Chang, "Radical initiation in the class I ribonucleotide reductase: Long range proton-coupled electron transfer?", Chem. Rev. 2003, 103, 2167-21201.

  22. M.C.Y. Chang, S.E. Miller, S.D. Carpenter, J. Stubbe, and D.G. Nocera, "Nanosecond generation of tyrosyl radicals via laser initiated decaging of oxalate-modified amino acids", J. Org. Chem. 2002, 67, 6820-6822.

  23. C.J. Chang, J.D.K. Brown, M.C.Y. Chang, E.A. Baker, and D.G. Nocera. "Electron Transfer in Hydrogen-Bonded Donor-Acceptor Supramolecules", In Electron Transfer in Chemistry, V. Balzani Ed., Wiley-VCH, Weinheim, Germany, 2001, Vol. 3.2.4., p 409-461.

  24. P.A. Sobecky, T.J. Mincer, M.C. Chang, A. Toudarian, and D.R. Helinski. "Isolation of broad-host-range replicons from marine sediment bacteria", Appl. Environ. Microbiol. 1998, 64, 2822-2830.

  25. P.A. Sobecky, T.J. Mincer, M.C. Chang, and D.R. Helinski. "Plasmids isolated from marine sediment microbial communities contain replication and incompatibility regions unrelated to those of known plasmid groups", Appl. Environ. Microbiol. 1997, 63, 888-895.




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