E.N. Kissman, M.E. Neugebauer, K.H. Sumida, C.V. Swenson, N.A. Sambold, J.A. Marchand, D.C. Millar, M.C.Y. Chang, "Biocatalytic control of site-selectivity and chain length-selectivity in radical amino acid halogenases", PNAS. 2023, 120 (12), pp.
S. Sirirungruang, O. Ad, T.M. Privalsky, S. Ramesh, J.L. Sax, H. Dong, E.E.K. Baidoo, B. Amer, C. Khosla, M.C.Y. Chang, "Engineering site-selective incorporation of fluorine into natural product analogs", Nat. Chem. Biol. 2022, , pp.
K. Thevasundaram, J. Gallagher, F. Cherng, M.C.Y. Chang, "Engineering nonphotosynthetic carbon fixation for production of bioplastics by methanogenic archaea", Proc. Natl. Acad. Sci. U.S.A. 2022, 119 (23), pp.
M.J. McBride, M.A. Nair, D. Sil, J.W. Slater, M.E. Neugebauer, M.C.Y. Chang, A.K. Boal, C. Krebs, J.M. Bollinger Jr, "Substrate-triggered μ-Peroxodiiron(III) Intermediate in the 4-chloro-L-lysine-fragmenting heme-oxygenase-like diiron oxidase (HDO) BesC: Substrate dissociation from, and C4 targeting by, the intermediate", Biochemistry 2022, no., pp.
J. Fang, L.E. Turner, M.C.Y. Chang, "Biocatalytic asymmetric construction of secondary and tertiary fluorides from β-fluoro-α-ketoacids", Angew. Chem. Int. Ed. 2022, no., pp.
M.E. Neugebauer, E.N. Kissman, J.A. Marchand, J.G. Pelton, N.A. Sambold, D.C. Millar, M.C.Y. Chang, "Reaction pathway engineering converts a radical hydroxylase into a halogenase", Nat. Chem. Biol. 2021, no., pp.
Z.Q. Wang, H. Song, E.J. Koleski, N. Hara, D.S. Park, G. Kumar, Y. Min, P.J. Dauenhauer, M.C.Y. Chang, "A dual cellular-heterogeneous catalyst strategy for the production of olefins from glucose", Nat. Chem. 2021, 13, 1178-1185.
H. Dong, M.C.Y. Chang, "Structural basis for branched substrate selectivity in a ketoreductase from Ascaris suum", ACS Catal. 2021, 11, 8948-8955.
H. Dong, S. Liffland, M.A. Hillmyer, M.C.Y. Chang, "Engineering in vivo production of α-branched polyesters", J. Am. Chem. Soc. 2019, 141, 16877-16883.
M.E. Neugebauer, K.H. Sumida, J.G. Pelton, J.L. McMurry, J.A. Marchand, M.C.Y. Chang, "A family of radical halogenases for the engineering of amino-acid-based products", Nat. Chem. Biol. 2019, 15, 1009-1016.
J. Fang, D. Hait, M. Head-Gordon, M.C.Y. Chang, "Chemoenzymatic platform for synthesis of chiral organofluorines based on type II aldolases", Angew. Chem. Int. Ed. 2019, 58, 11841-11845.
J.A. Marchand, M.E. Neugebauer, M.C. Ing, C.-I. Lin, J.G. Pelton, M.C.Y. Chang, "Discovery of a pathway for terminal-alkyne amino acid biosynthesis", Nature 2019, 567, 420-424.
A.M. Weeks, N. Wang, J.G. Pelton, M.C.Y. Chang, "Entropy drives selective fluorine recognition in the fluoroacetyl–CoA thioesterase from Streptomyces cattleya", Proc. Natl. Acad. Sci. U.S.A. 2018, 115, E2193-E2201.
M.R. Blaisse, B. Fu, M.C.Y. Chang, "Structural and Biochemical Studies of Substrate Selectivity in Ascaris suum Thiolases", Biochemistry 2018, 57, 3155-3166.
J.L. McMurry, M.C.Y. Chang, "Fluorothreonyl-tRNA deacylase prevents mistranslation in the organofluorine producer Streptomyces cattleya", Proc. Natl. Acad. Sci. U.S.A. 2017, 114, 11920-11925.
M.R. Blaisse, H. Dong, B. Fu, M.C.Y. Chang, "Discovery and engineering of pathways for production of α-branched organic acids", J. Am. Chem. Soc. 2017, 139, 14526-14532.
B.W. Thuronyi, T.M. Privalsky, M.C.Y. Chang, "Engineered fluorine metabolism and fluoropolymer production in living cells", Angew. Chem. Int. Ed. 2017, 56, 13637-13640.
O. Ad, B.W. Thuronyi, M.C.Y. Chang, "Elucidating the mechanism of fluorinated extender unit loading for improved production of fluorine-containing polyketides", Proc. Natl. Acad. Sci. U.S.A. 2017, 114, E660-E668.
V.Y. Yu, M.C.Y. Chang, "High-yield chemical synthesis by reprogramming central metabolism", Nat. Biotech. 2016, 34, 1128-1129.
D.M. Hersey, X. Ren , R.A. Melnyk, P.J. Browne, E. Ozyamak, S.R. Jones, M.C.Y. Chang, J.H. Hurley, A. Komeili, "MamO Is a repurposed serine protease that promotes magnetite biomineralization through direct transition metal binding in magnetotactic bacteria", PloS Biol. 2016, 14, e1002402.
E.M. Nichols, J.J. Gallagher, C. Liu, Y. Su, J. Resasco, Y. Yi, Y. Sun, P. Yang, M.C.Y. Chang, C.J. Chang, "Hybrid bioinorganic approach to solar-to-chemical conversion", Proc. Natl. Acad. Sci. U.S.A. 2015, 112, 11461-11466.
B.W. Thuronyi, M.C.Y. Chang, "Synthetic biology approaches to fluorinated polyketides", Acc. Chem. Res. 2015, 48, 584-592.
C. Liu, J.J. Gallagher, K.K. Sakimoto, E.M. Nichols, C.J. Chang, M.C.Y. Chang, P. Yang, "Nanowire–bacteria hybrids for unassisted solar carbon dioxide fixation to value-added chemicals", Nano Lett. 2015, 15, 3634-3639.
S.R. Jones, T.D. Wilson, M.E. Brown, L. Rahn-Lee, Y. Yu, L.L. Fredriksen, E. Ozyamak, A. Komeili, M.C.Y. Chang, "Genetic and biochemical investigations of the role of MamP in redox control of iron biomineralization in Magnetospirillum magneticum", Proc. Natl. Acad. Sci. U.S.A. 2015, 112, 3904-3909.
M.C. Walker, M.C.Y. Chang, "Natural and engineered biosynthesis of fluorinated natural products", Chem. Soc. Rev. 2014, 43, 6527-6536.
A.M. Weeks, N.S. Keddie, R.D.P. Wadoux, D. O'Hagan, M.C.Y. Chang, "Molecular recognition of fluorine impacts substrate selectivity in the fluoroacetyl-CoA thioesterase, FlK", Biochemistry 2014, 53, 2053-2063.
M.E. Brown, M.C.Y. Chang, "Exploring bacterial lignin degradation", Curr. Opin. Chem. Biol. 2014, 19, 1-7.
M.I. Siponen, P. Legrand, M. Widdrat, S.R. Jones, M.C.Y. Chang, D. Faivre, P. Arnoux, D. Pignol, "Structural insight into magnetochrome-mediated magnetite biomineralization", Nature 2013, 502, 681-684.
M.C. Walker, B.W. Thuronyi, L.K. Charkoudian, B. Lowry, C. Khosla, M.C.Y. Chang, "Expanding the fluorine chemistry of living systems using engineered polyketide synthase pathways", Science 2013, 341, 1089-1094.
M. Wen, B.B. Bond-Watts, M.C.Y. Chang, "Production of advanced biofuels in engineered E. coli", Curr. Opin. Chem. Biol. 2013, 17, 472-479.
A.M. Weeks, M.C.Y. Chang, "Catalytic control of enzymatic fluorine specificity", Proc. Natl. Acad. Sci. U.S.A. 2012, 109, 19667-19672.
M.E. Brown, T. Barros, M.C.Y. Chang, "Identification and characterization of a multi-functional dye peroxidase from a lignin-reactive bacterium", ACS Chem. Biol. 2012, 7, 2074-2081.
B.B. Bond-Watts, A.M. Weeks, M.C.Y. Chang, "Biochemical and structural characterization of the trans-enoyl-CoA reductase from Treponema denticola", Biochemistry 2012, 51, 6827-6837.
M.C. Walker, M. Wen, A.M. Weeks, M.C.Y. Chang, "Temporal and fluoride control of secondary metabolism regulates cellular organofluorine biosynthesis", ACS Chem. Biol. 2012, 7, 1576-1585.
M.E. Brown, M.C. Walker, T.G. Nakashige, A.T. Iavarone, M.C.Y. Chang, "Discovery and characterization of heme enzymes from unsequenced bacteria: Application to microbial lignin degradation", J. Am. Chem. Soc. 2011, 133, 18006-18009.
A.M. Weeks, M.C.Y. Chang, "Constructing de novo biosynthetic pathways for chemical synthesis inside living cells", Biochemistry 2011, 50, 5404-5418.
B.B. Bond-Watts, R.J. Bellerose, M.C.Y. Chang, "Enzyme mechanism and a kinetic control element for designing synthetic biofuel pathways", Nat. Chem. Biol. 2011, 7, 222-227.
A.M. Weeks, S.M. Coyle, M. Jinek, J.A. Doudna, M.C.Y. Chang, "Structural and biochemical studies of a fluoroacetyl-CoA thioesterase reveal a molecular basis for fluorine selectivity", Biochemistry 2010, 49, 9269-9279.
M.C.Y. Chang, "Harnessing energy from plant biomass", Curr. Opin. Chem. Biol. 2007, 11, 677-684.
J.A. Dietrich, Y. Yoshikuni, K.J. Fisher, F.X. Woolard, D. Ockney, D.J. McPhee, N.S. Nenninger, M.C.Y. Chang, D. Baker, J.D. Keasling, "A novel semi-biosynthetic route for artemisinin production using engineered substrate-promiscuous P450-BM3", ACS Chem. Biol. 2009, 4, 261-267.
M.C.Y. Chang, R.A. Eachus, W. Trieu, D.-K. Ro, J.D. Keasling, "Engineering Escherichia coli for production of functionalized terpenoids using plant P450s", Nat. Chem. Biol. 2007, 3, 274-277.
M.C.Y. Chang and J.D. Keasling, "Production of isoprenoid pharmaceuticals by engineered microbes", Nat. Chem. Biol. 2006, 2, 674-681.
J.D. Newman, J. Marshall, M.C.Y. Chang, F. Nowroozi, E.M. Paradise, D.P. Pitera, K.L. Newman, J.D. Keasling, "High-level production of amorpha-4,11-diene in a two-phase partitioning bioreactor of metabolically-engineered Escherichia coli", Biotechnol. Bioeng. 2006, 95, 684-691.
D.-K. Ro, E.M. Paradise, M. Ouellet, K.J. Fisher, K.L. Newman, J.M. Ndungu, K.A. Ho, R.A. Eachus, T. Ham, J. Kirby, M.C.Y. Chang, S.T. Withers, Y. Shiba, R. Sarpong, J.D. Keasling, "Production of the antimalarial drug precursor artemisinic acid in engineered yeast", Nature 2006, 440, 940-943.
M.C.Y. Chang, C.S. Yee, D.G. Nocera, J. Stubbe, "Site-specific replacement of a conserved tyrosine in ribonucleotide reductase with an aniline amino acid: A mechanistic probe for redox-active tyrosines", J. Am. Chem. Soc. 2004, 126, 16702-16703.
M.C.Y. Chang, A. Pralle, E.Y. Isacoff, C.J. Chang, "A selective, cell-permeable optical probe for hydrogen peroxide in living cells", J. Am. Chem. Soc. 2004, 126, 15392-15393.
M.C.Y. Chang, C.S. Yee, J. Stubbe, D.G. Nocera, "Turning on ribonucleotide reductase by light-initiated radical generation", Proc. Natl. Acad. Sci. U.S.A. 2004, 101, 6882-6887.
C.J. Chang, M.C.Y. Chang, N.H. Damrauer, D.G. Nocera, "Proton-coupled electron transfer: A unifying mechanism for biological charge transport, amino acid radical initiation and propagation, and bond making/breaking reactions of water and oxygen", Biochim. Biophys. Acta 2004, 1655, 13-28.
C.S. Yee, M.S. Seyedsayamdost, M.C.Y. Chang, D.G. Nocera, J. Stubbe, "Generation of the R2 subunit of ribonucleotide reductase by intein chemistry: Insertion of 3-nitrotyrosine at residue 356 as a probe of the radical initiation process", Biochemistry 2003, 42, 14541-14552.
C.S. Yee, M.C.Y. Chang, J. Ge, D.G. Nocera, J. Stubbe, "2,3-Difluorotyrosine at position 356 of ribonucleotide reductase R2: A probe of long-range proton-coupled electron transfer", J. Am. Chem. Soc. 2003, 125, 10506-10507.
J. Stubbe, D.G. Nocera, C.S. Yee, M.C.Y. Chang, "Radical initiation in the class I ribonucleotide reductase: Long range proton-coupled electron transfer?", Chem. Rev. 2003, 103, 2167-21201.
M.C.Y. Chang, S.E. Miller, S.D. Carpenter, J. Stubbe, D.G. Nocera, "Nanosecond generation of tyrosyl radicals via laser initiated decaging of oxalate-modified amino acids", J. Org. Chem. 2002, 67, 6820-6822.
C.J. Chang, J.D.K. Brown, M.C.Y. Chang, E.A. Baker, D.G. Nocera. "Electron Transfer in Hydrogen-Bonded Donor-Acceptor Supramolecules", in Electron Transfer in Chemistry, V. Balzani Ed., Wiley-VCH, Weinheim, Germany, 2001, Vol. 3.2.4., p 409-461.
P.A. Sobecky, T.J. Mincer, M.C. Chang, A. Toudarian, D.R. Helinski. "Isolation of broad-host-range replicons from marine sediment bacteria", Appl. Environ. Microbiol. 1998, 64, 2822-2830.
P.A. Sobecky, T.J. Mincer, M.C. Chang, D.R. Helinski. "Plasmids isolated from marine sediment microbial communities contain replication and incompatibility regions unrelated to those of known plasmid groups", Appl. Environ. Microbiol. 1997, 63, 888-895.