Publications

  1. J. Fang, D. Hait, M. Head-Gordon, M.C.Y. Chang, "Chemoenzymatic platform for synthesis of chiral organofluorines based on type II aldolases", Angew. Chem. Int. Ed. 2019.  [pdf] [SI]




  2. J.A. Marchand, M.E. Neugebauer, M.C. Ing, C.-I. Lin, J.G. Pelton, M.C.Y. Chang, "Discovery of a pathway for terminal-alkyne amino acid biosynthesis", Nature 2019.  [pdf] [C&E News] [Nature blog] [F1000Prime]




  3. A.M. Weeks, N. Wang, J.G. Pelton, M.C.Y. Chang, "Entropy drives selective fluorine recognition in the fluoroacetyl–CoA thioesterase from Streptomyces cattleya", Proc. Natl. Acad. Sci. U.S.A. 2018, 115, E2193-E2201.  [pdf] [SI]




  4. M.R. Blaisse, B. Fu, M.C.Y. Chang, "Structural and Biochemical Studies of Substrate Selectivity in Ascaris suum Thiolases", Biochemistry 2018, 57, 3155-3166.  [pdf] [SI]




  5. J.L. McMurry, M.C.Y. Chang, "Fluorothreonyl-tRNA deacylase prevents mistranslation in the organofluorine producer Streptomyces cattleya", Proc. Natl. Acad. Sci. U.S.A. 2017, 114, 11920-11925.  [pdf] [SI]




  6. M.R. Blaisse, H. Dong, B. Fu, M.C.Y. Chang, "Discovery and engineering of pathways for production of alpha-branched organic acids", J. Am. Chem. Soc. 2017, 139, 14526-14532.  [pdf] [SI]




  7. B.W. Thuronyi, T.M. Privalsky, M.C.Y. Chang, "Engineered fluorine metabolism and fluoropolymer production in living cells", Angew. Chem. Int. Ed. 2017, 56, 13637-13640.  [pdf] [SI] [Chemistry World] [C&E News]




  8. O. Ad, B.W. Thuronyi, M.C.Y. Chang, "Elucidating the mechanism of fluorinated extender unit loading for improved production of fluorine-containing polyketides", Proc. Natl. Acad. Sci. U.S.A. 2017, 114, E660-E668.  [pdf] [SI]




  9. V.Y. Yu, M.C.Y. Chang, "High-yield chemical synthesis by reprogramming central metabolism", Nat. Biotech. 2016, 34, 1128-1129.  [pdf]




  10. D.M. Hersey, X. Ren , R.A. Melnyk, P.J. Browne, E. Ozyamak, S.R. Jones, M.C.Y. Chang, J.H. Hurley, A. Komeili, "MamO Is a repurposed serine protease that promotes magnetite biomineralization through direct transition metal binding in magnetotactic bacteria", Acc. Chem. Res. 2015, 48, 584-592.  [pdf] [SI]




  11. E.M. Nichols, J.J. Gallagher, C. Liu, Y. Su, J. Resasco, Y. Yi, Y. Sun, P. Yang, M.C.Y. Chang, C.J. Chang, "Hybrid bioinorganic approach to solar-to-chemical conversion", Proc. Natl. Acad. Sci. U.S.A. 2015, 112, 11461-11466.  [pdf] [SI] [LBNL News Story] [ScienceDaily News Story] [Adaptive Scientist News Story]




  12. B.W. Thuronyi, M.C.Y. Chang, "Synthetic biology approaches to fluorinated polyketides", Acc. Chem. Res. 2015, 48, 584-592.  [pdf]




  13. C. Liu, J.J. Gallagher, K.K. Sakimoto, E.M. Nichols, C.J. Chang, M.C.Y. Chang, P. Yang, "Nanowire–bacteria hybrids for unassisted solar carbon dioxide fixation to value-added chemicals", Nano Lett. 2015, 15, 3634-3639.  [pdf] [SI] [LBNL News Story] [Tech Times News Story] [Science Times News Story] [News Everyday News Story] [Huffington Post article] [KALWRadio]




  14. S.R. Jones, T.D. Wilson, M.E. Brown, L. Rahn-Lee, Y. Yu, L.L. Fredriksen, E. Ozyamak, A. Komeili, M.C.Y. Chang, "Genetic and biochemical investigations of the role of MamP in redox control of iron biomineralization in Magnetospirillum magneticum", Proc. Natl. Acad. Sci. U.S.A. 2015, 112, 3904-3909.  [pdf] [SI]




  15. M.C. Walker, M.C.Y. Chang, "Natural and engineered biosynthesis of fluorinated natural products", Chem. Soc. Rev. 2014, 43, 6527-6536.  [pdf]


  16. A.M. Weeks, N.S. Keddie, R.D.P. Wadoux, D. O'Hagan, M.C.Y. Chang, "Molecular recognition of fluorine impacts substrate selectivity in the fluoroacetyl-CoA thioesterase, FlK", Biochemistry 2014, 53, 2053-2063.  [pdf] [SI]




  17. M.E. Brown, M.C.Y. Chang, "Exploring bacterial lignin degradation", Curr. Opin. Chem. Biol. 2014, 19, 1-7.  [pdf]


  18. M.I. Siponen, P. Legrand, M. Widdrat, S.R. Jones, M.C.Y. Chang, D. Faivre, P. Arnoux, D. Pignol, "Structural insight into magnetochrome-mediated magnetite biomineralization", Nature 2013, 502, 681-684.  [pdf]




  19. M.C. Walker, B.W. Thuronyi, L.K. Charkoudian, B. Lowry, C. Khosla, M.C.Y. Chang, "Expanding the fluorine chemistry of living systems using engineered polyketide synthase pathways", Science 2013, 341, 1089-1094.  [pdf] [SI] [News & Analysis] [C&E News]




  20. M. Wen, B.B. Bond-Watts, M.C.Y. Chang, "Production of advanced biofuels in engineered E. coli", Curr. Opin. Chem. Biol. 2013, 17, 472-479.  [pdf]


  21. A.M. Weeks, M.C.Y. Chang, "Catalytic control of enzymatic fluorine specificity", Proc. Natl. Acad. Sci. U.S.A. 2012, 109, 19667-19672.  [pdf] [SI] [C&E News]




  22. M.E. Brown, T. Barros, M.C.Y. Chang, "Identification and characterization of a multi-functional dye peroxidase from a lignin-reactive bacterium", ACS Chem. Biol. 2012, 7, 2074-2081.  [pdf] [SI]




  23. B.B. Bond-Watts, A.M. Weeks, M.C.Y. Chang, "Biochemical and structural characterization of the trans-enoyl-CoA reductase from Treponema denticola", Biochemistry 2012, 51, 6827-6837.  [pdf] [SI]




  24. M.C. Walker, Miao Wen, A.M. Weeks, M.C.Y. Chang, "Temporal and fluoride control of secondary metabolism regulates cellular organofluorine biosynthesis", ACS Chem. Biol. 2012, 7, 1576-1585.  [pdf] [SI]




  25. M.E. Brown, M.C. Walker, T.G. Nakashige, A.T. Iavarone, M.C.Y. Chang, "Discovery and characterization of heme enzymes from unsequenced bacteria: Application to microbial lignin degradation", J. Am. Chem. Soc. 2011, 133, 18006-18009.  [pdf] [SI] [JACS cover]




  26. A.M. Weeks, M.C.Y. Chang, "Constructing de novo biosynthetic pathways for chemical synthesis inside living cells", Biochemistry 2011, 50, 5404-5418.  [pdf]




  27. B.B. Bond-Watts, R.J. Bellerose, M.C.Y. Chang, "Enzyme mechanism and a kinetic control element for designing synthetic biofuel pathways", Nat. Chem. Biol. 2011, 7, 222-227.  [pdf] [News & Views] [MSNBC News] [UCB News] [C&E News] [German Public Radio interview] [SETI Big Picture Science Podcast]




  28. A.M. Weeks, S.M. Coyle, M. Jinek, J.A. Doudna, M.C.Y. Chang, "Structural and biochemical studies of a fluoroacetyl-CoA thioesterase reveal a molecular basis for fluorine selectivity", Biochemistry 2010, 49, 9269-9279.  [pdf] [SI]




  29. M.C.Y. Chang, "Harnessing energy from plant biomass", Curr. Opin. Chem. Biol. 2007, 11, 677-684.  [pdf]



  30. J.A. Dietrich, Y. Yoshikuni, K.J. Fisher, F.X. Woolard, D. Ockney, D.J. McPhee, N.S. Nenninger, M.C.Y. Chang, D. Baker, J.D. Keasling, "A novel semi-biosynthetic route for artemisinin production using engineered substrate-promiscuous P450-BM3", ACS Chem. Biol. 2009, 4, 261-267.

  31. M.C.Y. Chang, R.A. Eachus, W. Trieu, D.-K. Ro, J.D. Keasling, "Engineering Escherichia coli for production of functionalized terpenoids using plant P450s", Nat. Chem. Biol. 2007, 3, 274-277.

  32. M.C.Y. Chang and J.D. Keasling, "Production of isoprenoid pharmaceuticals by engineered microbes", Nat. Chem. Biol. 2006, 2, 674-681.

  33. J.D. Newman, J. Marshall, M.C.Y. Chang, F. Nowroozi, E.M. Paradise, D.P. Pitera, K.L. Newman, J.D. Keasling, "High-level production of amorpha-4,11-diene in a two-phase partitioning bioreactor of metabolically-engineered Escherichia coli", Biotechnol. Bioeng. 2006, 95, 684-691.

  34. D.-K. Ro, E.M. Paradise, M. Ouellet, K.J. Fisher, K.L. Newman, J.M. Ndungu, K.A. Ho, R.A. Eachus, T. Ham, J. Kirby, M.C.Y. Chang, S.T. Withers, Y. Shiba, R. Sarpong, J.D. Keasling, "Production of the antimalarial drug precursor artemisinic acid in engineered yeast", Nature 2006, 440, 940-943.

  35. M.C.Y. Chang, C.S. Yee, D.G. Nocera, J. Stubbe, "Site-specific replacement of a conserved tyrosine in ribonucleotide reductase with an aniline amino acid: A mechanistic probe for redox-active tyrosines", J. Am. Chem. Soc. 2004, 126, 16702-16703.

  36. M.C.Y. Chang, A. Pralle, E.Y. Isacoff, C.J. Chang, "A selective, cell-permeable optical probe for hydrogen peroxide in living cells", J. Am. Chem. Soc. 2004, 126, 15392-15393.

  37. M.C.Y. Chang, C.S. Yee, J. Stubbe, D.G. Nocera, "Turning on ribonucleotide reductase by light-initiated radical generation", Proc. Natl. Acad. Sci. U.S.A. 2004, 101, 6882-6887.

  38. C.J. Chang, M.C.Y. Chang, N.H. Damrauer, D.G. Nocera, "Proton-coupled electron transfer: A unifying mechanism for biological charge transport, amino acid radical initiation and propagation, and bond making/breaking reactions of water and oxygen", Biochim. Biophys. Acta 2004, 1655, 13-28.

  39. C.S. Yee, M.S. Seyedsayamdost, M.C.Y. Chang, D.G. Nocera, J. Stubbe, "Generation of the R2 subunit of ribonucleotide reductase by intein chemistry: Insertion of 3-nitrotyrosine at residue 356 as a probe of the radical initiation process", Biochemistry 2003, 42, 14541-14552.

  40. C.S. Yee, M.C.Y. Chang, J. Ge, D.G. Nocera, J. Stubbe, "2,3-Difluorotyrosine at position 356 of ribonucleotide reductase R2: A probe of long-range proton-coupled electron transfer", J. Am. Chem. Soc. 2003, 125, 10506-10507.

  41. J. Stubbe, D.G. Nocera, C.S. Yee, M.C.Y. Chang, "Radical initiation in the class I ribonucleotide reductase: Long range proton-coupled electron transfer?", Chem. Rev. 2003, 103, 2167-21201.

  42. M.C.Y. Chang, S.E. Miller, S.D. Carpenter, J. Stubbe, D.G. Nocera, "Nanosecond generation of tyrosyl radicals via laser initiated decaging of oxalate-modified amino acids", J. Org. Chem. 2002, 67, 6820-6822.

  43. C.J. Chang, J.D.K. Brown, M.C.Y. Chang, E.A. Baker, D.G. Nocera. "Electron Transfer in Hydrogen-Bonded Donor-Acceptor Supramolecules", in Electron Transfer in Chemistry, V. Balzani Ed., Wiley-VCH, Weinheim, Germany, 2001, Vol. 3.2.4., p 409-461.

  44. P.A. Sobecky, T.J. Mincer, M.C. Chang, A. Toudarian, D.R. Helinski. "Isolation of broad-host-range replicons from marine sediment bacteria", Appl. Environ. Microbiol. 1998, 64, 2822-2830.

  45. P.A. Sobecky, T.J. Mincer, M.C. Chang, D.R. Helinski. "Plasmids isolated from marine sediment microbial communities contain replication and incompatibility regions unrelated to those of known plasmid groups", Appl. Environ. Microbiol. 1997, 63, 888-895.




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