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Research

Matt Francis

The Group

Publications

 

 

Recent Publications

2012

Twite AA, Hsiao SC, Onoe H, Mathies RA, Francis MB. Direct Attachment of Microbial Organisms to Material Surfaces Through Sequence-Specific DNA Hybridization. Adv Mater. 2012. Epub ahead of print. Link

2011

Stephanopoulos N, Francis MB. Choosing an effective protein bioconjugation strategy. Nat Chem Biol. 2011;7(12):876-84. Link

Dedeo MT, Finley DT, Francis MB. Viral capsids as self-assembling templates for new materials. Prog Mol Biol Transl Sci. 2011;103:353-92. Link

Seim KL, Obermeyer AC, Francis MB. Oxidative Modification of Native Protein Residues Using Cerium(IV) Ammonium Nitrate. J Am Chem Soc. 2011; 7(12):876-84. Link

Behrens CR, Hooker JM, Obermeyer AC, Romanini DW, Katz EM, Francis MB. Rapid Chemoselective Bioconjugation Through the Oxidative Coupling of Anilines and Aminophenols. J Am Chem Soc. 2011;133(41):16398-401Link

Witus LS, Francis MB. Using Synthetically Modified Proteins to Make New Materials. Acc Chem Res. 2011; 44(9):774-83. Link

Garimella PD, Datta A, Romanini DW, Raymond KN, Francis MB. Multivalent, high-relaxivity MRI contrast agents using rigid cysteine-reactive gadolinium complexes. J Am Chem Soc. 2011;133(37):14704-9. Link

2010

Francis MB, Carrico I. New frontiers in protein bioconjugation. Curr Opin Chem Biol. 2010;14(6):771-3. Link

Witus LS, Moore T, Thuronyi BW, Esser-Kahn AP, Scheck RA, Iavarone AT, Francis MB. Identification of Highly Reactive Sequences For PLP-Mediated Bioconjugation Using a Combinatorial Peptide Library. J Am Chem Soc. 2010;132(47):16812-7. Link

Holder PG, Finley DT, Stephanopoulos N, Walton R, Clark DS, Francis MB. Dramatic thermal stability of virus-polymer conjugates in hydrophobic solvents. Langmuir. 2010;26(22):17383-8. Link

Stephanopoulos N, Tong GJ, Hsiao SC, Francis MB. Dual-surface modified virus capsids for targeted delivery of photodynamic agents to cancer cells. ACS Nano. 2010 Oct 26;4(10):6014-20. Link

Esser-Kahn AP, Trang V, Francis MB. Incorporation of antifreeze proteins into polymer coatings using site-selective bioconjugation. J Am Chem Soc. 2010 Sep 29;132(38):13264-9. Link

Witus LS and Francis MB. Site-Specific Protein Bioconjugation via a Pyridoxal 5′-Phosphate-Mediated N-Terminal Transamination Reaction. Curr Protoc in Chem Biol. 2010;125–134.

Stephanopoulos N, Liu M, Tong GJ, Li Z, Liu Y, Yan H, Francis MB. Immobilization and one-dimensional arrangement of virus capsids with nanoscale precision using DNA origami. Nano Lett. 2010;10(7):2714-20. Link

Crochet AP, Kabir MM, Francis MB, Paavola CD. Site-selective dual modification of periplasmic binding proteins for sensing applications. Biosens Bioelectron. 2010;26(1):55-61. Link

Miller RA, Stephanopoulos N, McFarland JM, Rosko AS, Geissler PL, Francis MB. Impact of assembly state on the defect tolerance of TMV-based light harvesting arrays. J Am Chem Soc. 2010;132(17):6068-74. Link

Meldrum T, Seim KL, Bajaj VS, Palaniappan KK, Wu W, Francis MB, Wemmer DE, Pines A. A xenon-based molecular sensor assembled on an MS2 viral capsid scaffold. J Am Chem Soc: 2010; 132(17):5936-7.Link

Dedeo MT, Duderstadt KE, Berger JM, Francis MB. Nanoscale Protein Assemblies from a Circular Permutant of the Tobacco Mosaic Virus. Nano Lett. 2010;10(1):181-186. Link

 

2009

Antos JM, McFarland JM, Iavarone AT, Francis MB. Chemoselective Tryptophan Labeling with Rhodium Carbenoids at Mild pH. J. Am. Chem. Soc. 2009;131(17):6301-6308. Link

Douglas ES, Hsiao SC, Onoe H, et al. DNA-barcode directed capture and electrochemical metabolic analysis of single mammalian cells on a microelectrode array. Lab Chip. 2009;9(14):2010-2015. Link

Hsiao SC, Shum BJ, Onoe H, et al. Direct Cell Surface Modification with DNA for the Capture of Primary Cells and the Investigation of Myotube Formation on Defined Patterns. Langmuir. 2009;25(12):6985-6991. Link

Stephanopoulos N, Carrico ZM, Francis MB. Nanoscale Integration of Sensitizing Chromophores and Porphyrins with Bacteriophage MS2. Angew. Chem., Int. Ed. 2009;48(50):9498-9502, S9498/1-S9498/14. Link

Tilley SD, Joshi NS, Francis MB. Proteins: chemistry and chemical reactivity. In:  Wiley Encycl. Chem. Biol.Vol 4. John Wiley & Sons, Inc.; 2009:158-174.

Tong GJ, Hsiao SC, Carrico ZM, Francis MB. Viral Capsid DNA Aptamer Conjugates as Multivalent Cell-Targeting Vehicles. J. Am. Chem. Soc. 2009;131(31):11174-11178. Link

Wu W, Hsiao SC, Carrico ZM, Francis MB. Genome-Free Viral Capsids as Multivalent Carriers for Taxol Delivery. Angew. Chem., Int. Ed. 2009;48(50):9493-9497, S9493/1-S9493/12. Link

 

2008

Carrico ZM, Romanini DW, Mehl RA, Francis MB. Oxidative coupling of peptides to a virus capsid containing unnatural amino acids. Chem. Commun. 2008;(10):1205-1207. Link

Chung S, Presley AD, Elhadj S, et al. Scanning probe-based fabrication of 3D nanostructures via affinity templates, functional RNA, and meniscus-mediated surface remodeling. Scanning. 2008;30(2):159-171. Link

Datta A, Hooker JM, Botta M, et al. High Relaxivity Gadolinium Hydroxypyridonate-Viral Capsid Conjugates: Nanosized MRI Contrast Agents. J. Am. Chem. Soc. 2008;130(8):2546-2552. Link

Esser-Kahn AP, Francis MB. Protein-cross-linked polymeric materials through site-selective bio-conjugation. Angew. Chem., Int. Ed. 2008;47(20):3751-3754. Link

Esser-Kahn AP, Iavarone AT, Francis MB. Metallothionein-Cross-Linked Hydrogels for the Selective Removal of Heavy Metals from Water. J. Am. Chem. Soc. 2008;130(47):15820-15822. Link

Hooker JM, O'Neil JP, Romanini DW, Taylor SE, Francis MB. Genome-free viral capsids as carriers for positron emission tomography radiolabels. Mol Imaging Biol. 2008;10(4):182-91. Link

Hsiao SC, Crow AK, Lam WA, et al. DNA-coated AFM cantilevers for the investigation of cell adhesion and the patterning of live cells. Angew. Chem., Int. Ed. 2008;47(44):8473-8477. Link

Ma Y, Miller RA, Fleming GR, Francis MB. Energy Transfer Dynamics in Light-Harvesting Assemblies Templated by the Tobacco Mosaic Virus Coat Protein. J. Phys. Chem. B. 2008;112(22):6887-6892. Link

McFarland JM, Joshi NS, Francis MB. Characterization of a Three-Component Coupling Reaction on Proteins by Isotopic Labeling and Nuclear Magnetic Resonance Spectroscopy. J. Am. Chem. Soc. 2008;130(24):7639-7644. Link

Romanini DW, Francis MB. Attachment of Peptide Building Blocks to Proteins Through Tyrosine Bioconjugation. Bioconjugate Chem. 2008;19(1):153-157. Link

Scheck RA, Dedeo MT, Iavarone AT, Francis MB. Optimization of a Biomimetic Transamination Reaction. J. Am. Chem. Soc. 2008;130(35):11762-11770. Link

Toriello NM, Douglas ES, Thaitrong N, et al. Integrated microfluidic bioprocessor for single-cell gene expression analysis. Proc Natl Acad Sci U S A. 2008;105(51):20173-8. Link

2007

Douglas ES, Chandra RA, Bertozzi CR, Mathies RA, Francis MB. Self-assembled cellular microarrays patterned using DNA barcodes. Lab Chip. 2007;7(11):1442-1448. Link

Francis MB. New methods for protein bioconjugation. In:  Chem. Biol.Vol 2. Wiley-VCH Verlag GmbH & Co. KGaA; 2007:593-634. Link

Francis MB, Doudna-Cate JH. Chemical Biology at Berkeley. ACS Chem. Biol. 2007;2(11):702-705. Link

Holder PG, Francis MB. Integration of a self-assembling protein scaffold with water-soluble single-walled carbon nanotubes. Angew. Chem., Int. Ed. 2007;46(23):4370-4373. Link

 Hooker JM, Datta A, Botta M, Raymond KN, Francis MB. Magnetic Resonance Contrast Agents from Viral Capsid Shells: A Comparison of Exterior and Interior Cargo Strategies. Nano Lett. 2007;7(8):2207-2210. Link

Johnson HR, Hooker JM, Francis MB, Clark DS. Solubilization and stabilization of bacteriophage MS2 in organic solvents. Biotechnol. Bioeng. 2007;97(2):224-234. Link

Kovacs EW, Hooker JM, Romanini DW, et al. Dual-Surface-Modified Bacteriophage MS2 as an Ideal Scaffold for a Viral Capsid-Based Drug Delivery System. Bioconjugate Chem. 2007;18(4):1140-1147. Link

Miller RA, Presley AD, Francis MB. Self-Assembling Light-Harvesting Systems from Synthetically Modified Tobacco Mosaic Virus Coat Proteins. J. Am. Chem. Soc. 2007;129(11):3104-3109. Link

Scheck RA, Francis MB. Regioselective labeling of antibodies through N-terminal transamination. ACS Chem. Biol. 2007;2(4):247-251. Link

 

2006

Antos JM, Francis MB. Transition metal catalyzed methods for site-selective protein modification. Curr. Opin. Chem. Biol. 2006;10(3):253-262.

Chandra RA, Douglas ES, Mathies RA, Bertozzi CR, Francis MB. Programmable cell adhesion encoded by DNA hybridization. Angew. Chem., Int. Ed. 2006;45(6):896-901.

Gilmore JM, Scheck RA, Esser-Kahn AP, Joshi NS, Francis MB. N-terminal protein modification through a biomimetic transamination reaction. Angew. Chem., Int. Ed. 2006;45(32):5307-5311.

Hooker JM, Esser-Kahn AP, Francis MB. Modification of Aniline Containing Proteins Using an Oxidative Coupling Strategy. J. Am. Chem. Soc. 2006;128(49):15558-15559.

Nguyen T, Joshi NS, Francis MB. An Affinity-Based Method for the Purification of Fluorescently-Labeled Biomolecules. Bioconjugate Chem. 2006;17(4):869-872.

Tilley SD, Francis MB. Tyrosine-Selective Protein Alkylation Using π-Allylpalladium Complexes. J. Am. Chem. Soc. 2006;128(4):1080-1081.

 

2005


McFarland JM, Francis MB. Reductive Alkylation of Proteins Using Iridium Catalyzed Transfer Hydrogenation. J. Am. Chem. Soc. 2005;127(39):13490-13491.

Schlick TL, Ding Z, Kovacs EW, Francis MB. Dual-surface modification of the Tobacco mosaic virus. J. Am. Chem. Soc. 2005;127(11):3718-3723.

 

2004

Antos JM, Francis MB. Selective tryptophan modification with rhodium carbenoids in aqueous solution. J. Am. Chem. Soc. 2004;126(33):10256-10257.

 Hooker JM, Kovacs EW, Francis MB. Interior surface modification of bacteriophage MS2. J. Am. Chem. Soc. 2004;126(12):3718-3719.

Joshi NS, Whitaker LR, Francis MB. A Three-Component Mannich-Type Reaction for Selective Tyrosine Bioconjugation. J. Am. Chem. Soc. 2004;126(49):15942-15943.

 

2003

Nguyen T, Francis MB. Practical synthetic route to functionalized rhodamine dyes. Org. Lett. 2003;5(18):3245-3248.
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