Klinman JP. Beyond tunneling corrections: full tunneling modes for enzymatic C-H activation reactions. RSC-Quantum Tunneling in Enzyme Catalyzed Reactions (Biomolecular Series), in press.

Hess CR, Wu Z, Klinman JP. Hydroxylase activity of Met471Cys tyramine beta-monooxygenase. J Am Chem Soc, in press.

Hess CR, Welford RDW, Klinman JP. Chemstry of oxygen activating enzymes. Encyclopedia of Chemical Biology, Wiley and Sons, in press.

Mirica LM, McCusker KP, Munos JW, Liu, H-w, Klinman JP. 18O kinetic isotope effects in non-heme iron enzymes: probing the nature of Fe/O2 intermediates. J am chem Soc 2008; 130, 8122-8123.

Mirica LM, Klinman JP. The nature of O2 activation by the ethylene-forming enzyme ACC oxidase. Proc Natl Acad Sci USA 2008; 105, 1814-1819.

Meyer MP, Tomchick DR, Klinman JP. Enzyme structure and dynamics affect hydrogen tunneling: the impact of a remote side chain (I553) in soybean lipoxygenase-1. Proc Natl Acad Sci USA 2008; 105, 1146-1151.

Meyer M, Klinman JP. Synthesis of linoleic acids combinatorially-labeled at the vinylic positions as substrates for soybean lipoxygenase-1 isotope effect studies. Tet Letts 2008;49, 3600-3603.

Hess CR, McGuirl MM, Klinman JP. Mechanism of the Insect Enzyme, tyramine beta-monooxygenase, reveals differences with the mammalian enzyme, dopamine beta-monooxxyugenase. J Biol Chem 2008;283, 3042-3049.

Welford RDW, Lam A, Mirica LM, Klinman JP. Partial conversion of Hansenula polymorpha amine oxidase into a 'plant' amine oxidase: implications for copper chemistry and mechanism. Biochemistry 2007; 46, 10817-10827.

Johnson BJ, Cohen J, Welford RW, Pearson AR, Schulten K, Klinman JP, Wilmot CM. Exploring molecular oxygen pathways in Hansenula polymorpha copper-containinbg amine oxidase. J Biol Chem 2007; 282, 17767-17776.

Magnusson OT, RoseFigura JM, Toyama H, Schwarzenbacher R, Klinman JP. Pyrroloquinolinequinone biogenesis: Characterization of PqqC and its H84N and H84A active site variants. Biochemistry 2007; 46, 7174-7186.

Klinman JP. How do enzymes activate oxygen without inactivating themselves? Acc Chem Res 2007; 40, 325-333.

Knapp MJ, Meyer MP, Klinman JP.  Nuclear tunneling in condensed phase: Hydrogen transfer in enzyme reactions in “Hydrogen Transfer Reactions”, (Schowen R, Klinman JP, eds) Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim, Germany (2007), Vol. 4, pp 1241-1284. 

Purdy MM, Koo LS, Ortiz de Montellano PR, Klinman JP.  Mechanism of O2 activation by cytochrome P450cam studied by isotope effects and transient state kinetics. Biochemistry 2006; 45:15793-15806. 

Evans JP, Blackburn NJ, Klinman JP. The catalytic role of the copper ligand H172 of peptidylglycine alpha-hydroxylating monooxygenase: A kinetic study of H172A mutant. Biochemistry 2006 ; 45:15419-15429.

Ghattas W, Hess CR, Iacazio G, Klinman JP, Reglier M. Pathway for the stereo-controlled Z and E production of alpha,alpha-difluorine-substituted phenyl butenoates. J Org Chem 2006; 71:8618-8621.

Thrower J, Mirica LM, McCusker KP, Klinman JP. Mechanistic investigations of 1-aminocyclopropane 1-carboxylic acid oxidase with alternate cyclic and acyclic substrates. Biochemistry, 2006; 45:13108-13117.

Rickert K, Klinman JP. Radical generation-lipoxygenase (Chapter XIII) in Biological Inorganic Chemistry: Structure and Reactivity, (Bertini I, Gray H, Stiefel EI, Valentine JS, eds) University Science Books, Inc, Mill Valley, California (2006), pp 607-612.

Klinman JP.  The role of tunneling in enzyme catalysis of C-H activation in Biochim Biophys Acta - Bioenergetics Special Issue, Proton Transfer Reactions in Biological Systems, 2006; 1757:981-987.

Nagel Z, Klinman JP.  Tunneling and dynamics in enzymatic hydride transfer.  Solicited Review. Chem Rev 2006; 106:3095-3118.

Samuels NM, Klinman JP.  Investigation of Cu(I)-dependent 2,4,5-trihydroxyphenylalanine quinone (TPQ) biogenesis in Hansenula polymorpha amine oxidase. J Biol Chem 2006; 281:21114-21118.

Klinman JP. Linking protein structure and dynamics to catalysis: The role of hydrogen tunneling. Phil Trans R Soc B 2006; 361:1323-1331.

Takahashi K, Klinman JP. Relationship of stopped flow to steady state parameters in the dimeric copper amine oxidase from Hansenula polymorpha and the role of zinc-inhibiting activity at alternate copper-containing subunits. Biochemistry 2006; 45:4683-4694.

DuBois JL, Klinman JP.  Role of a strictly-conserved active site tyrosine in cofactor genesis in the copper amine oxidase from Hansenula polymorpha. Biochemistry 2006; 45:3178-3188.

Klinman JP. The copper enzyme family of dopamine beta-monooxygenase and peptidylglycine-alpha-hydroxylating monooxygenase: Resolving the chemical pathway for substrate hydroxylation.  Solicited minireview for J Biol Chem 2006; 281:3013-3016.

Roth JP, Klinman JP. Oxygen-18 isotope effects as a probe of enzymatic activation of molecular oxygen in Isotope Effects in Chemistry and Biology, pp 645-669 (Kohen A, Limbach H, eds) Taylor and Francis, Inc., Boca Raton, FL (2006).

Meyer M, Klinman JP. Modeling temperature-dependent kinetic isotope effects for hydrogen transfer in a series of soybean lipoxygenase mutants: the effect of anharmonicity upon transfer distance. Chem Phys 2005; 319:283-296. 

Samuels NM, Klinman JP. 2,4,5-trihydroxyphenylalanine quinone biogenesis in the copper amine oxidase from Hansenula polymorpha with the alternate metal, nickel. Biochemistry 2005; 44:14308-14317.

Kim HS, Damo SM, Lee S-Y, Wemmer DE, Klinman JP. Structure and hydride transfer mechanism of a moderate thermophilic dihydrofolate reductase from Bacillus stearothermophilus and comparison to its mesophilic and hyperthermophilic homologs. Biochemistry 2005; 44:11428-11439.

DuBois JL, Klinman JP.  Nature of O2 reactivity leading to topa quinone in the copper amine oxidase from Hansenula polymorpha and its relationship to catalytic turnover. Biochemistry 2005; 44:11381-11388.

Limburg J, Mure M, Klinman JP.  Cloning and characterization of histamine dehydrogenase NSHADH from Nocardioides simplex. Arch Biochem Biophys 2005; 436:8-22.

Dubois JL, Klinman JP.  Mechanism of post-translational quinone formation in copper amine oxidases and its relationship to the catalytic turnover. Special Issue of Arch Biochem Biophys 2005; 433:255-265.

Roth JP, Wincek R, Nodet G, Edmondson DE, McIntire WS, Klinman JP. Oxygen isotope effects on electron transfer to O2 probed using chemically modified flavins bound to glucose oxidase. J Am Chem Soc 2004; 126:15120-15131.

Liang Z-X, Klinman JP. Structural bases for hydrogen tunneling in enzymes: progress and puzzles. Curr Opin Struct Biol 2004; 14:648-655.

Liang Z-X, Tsigos I, Bouriotis V, Lee T, Resing KA, Ahn NT, Klinman JP. Evidence for increased local flexibility in psychrophilic alcohol dehydrogenase relative to its thermophilic homologue. Biochemistry 2004; 43:14676-14683.

Francisco WA, Wille G, Smith AJ, Merkler DJ, Klinman JP. Investigation of the pathway for the inter-copper electron transfer in peptidylglycine alpha-amidating monooxygenase. J Am Chem Soc 2004; 126:13168-13169.

Roth JP, Klinman JP. Kinetic isotope effects in Encyclopedia of Biological Chemistry Vol 2, pp 522-528 (Lennarz WJ and Lane MD eds), Elsevier, Oxford, UK (2004).

Liang Z-X, Tsigos I, Bouriotis V, Klinman JP. Impact of protein flexibility on hydride-transfer parameters in thermophilic and psychrophilic alcohol dehydrogenases. J Am Chem Soc 2004; 126:9500-9501.

Liang ZX, Lee T, Resing KA, Ahn NG, Klinman JP. Thermal-activated protein mobility and its correlation with catalysis in thermophilic alcohol dehydrogenase. Proc Natl Acad Sci USA 2004; 101:9556-9561.

Magnusson OT, Toyama H, Saeki M, Rojas A, Reed JC, Liddington RC, Klinman JP, Schwarzenbacher R. Quinone biogenesis: Structure and mechanism of PqqC, the final catalyst in the production of pyrroloquinoline quinone. Proc Natl Acad Sci USA 2004; 101:7913-7918.

Magnusson OT, Toyama H, Saeki M, Schwarzenbacher R, Klinman JP.The structure of a biosynthetic intermediate of pyrroloquinoline quinone (PQQ) and elucidation of the final step of PQQ biosynthesis. J Am Chem Soc 2004; 126:5342-5343.

DuBois JL, Klinman JP. Methods for characterizing TPQ-containing proteins. Methods Enzymol 2004; 378:17-31.

Ceccarelli C, Liang Z-X, Strickler M, Prehna G, Goldstein BM, Klinman JP, Bahnson BJ. Crystal structure and amide H/D exchange of binary complexes of alcohol dehydrogenase from Bacillus stearothermophilus: insight into thermostability and cofactor binding. Biochemistry 2004; 43:5266-5277.

Purdy MM, Koo LS, Ortiz de Montellano PR, Klinman JP. Steady-state kinetic investigation of cytochrome P450cam: Interaction with redox partners and reaction with molecular oxygen. Biochemistry 2004; 43:271-281.

Evans JP, Ahn K, Klinman JP. Evidence that dioxygen and substrate activation are tightly coupled in dopamine beta-monooxygenase. Implications for the reactive oxygen species. J Biol Chem 2003; 278:49691-49698.

Knapp MJ, Klinman JP. Kinetic studies of oxygen reactivity in soybean lipoxygenase-1. Biochemistry 2003; 42:11466-11475.

Mure M, Wang SX, Klinman JP. Synthesis and characterization of model compounds of the lysine tyrosyl quinone cofactor of lysyl oxidase. J Am Chem Soc 2003; 125:6113-6125.

Klinman JP. The multi-functional topa-quinone copper amine oxidases. Biochim Biophys Acta 2003; 1647:131-137.

Tsai SC, Klinman JP. De Novo design and utilization of photolabile caged substrates as probes of hydrogen tunneling with horse liver alcohol dehydrogenase at sub-zero temperatures: a cautionary note. Bioorg Chem 2003; 31:170-188.

Francisco WA, Blackburn NJ, Klinman JP. Oxygen and hydrogen isotope effects in an active site tyrosine to phenylalanine mutant of peptidylglycine alpha-hydroxylating monooxygenase: mechanistic implications. Biochemistry 2003; 42:1813-1819.

Roth JP, Klinman JP. Catalysis of electron transfer during activation of O2 by the flavoprotein glucose oxidase. Proc Natl Acad Sci USA 2003; 100:62-67.

Goto Y, Klinman JP. Binding of dioxygen to non-metal sites in proteins: Exploration of the importance of binding site size versus hydrophobicity in the copper amine oxidase from Hansenula polymorpha. Biochemistry 2002; 41:13637-43.

Mills SA, Goto Y, Su Q, Plastino J, Klinman JP. Mechanistic comparision of the cobalt-substituted and wild-type copper amine oxidase from Hansenula polymorpha. Biochemistry 2002; 41:10577-84.

Mure M, Mills SA, Klinman JP. Catalytic mechanism of the topaquinone containing copper amine oxidases. Biochemistry 2002; 41:9269-78.

Francisco WA, Knapp MJ, Blackburn NJ, Klinman JP. Hydrogen tunneling in peptidylglycine alpha-hydroxylating monooxygenase. J Am Chem Soc 2002; 124:8194-5.

Seymour SL, Klinman JP. Comparison of rates and kinetic isotope effects using PEG-modified variants and glycoforms of glucose oxidase: the relationship of modification of the protein envelope to C-H activation and tunneling. Biochemistry 2002; 41:8747-58.

Knapp MJ, Klinman JP. Environmentally coupled hydrogen tunneling. Eur J Biochem 2002; 269:3113-21.

Knapp MJ, Rickert K, Klinman JP. Temperature-dependent isotope effects in soybean lipoxygenase-1: correlating hydrogen tunneling with protein dynamics. J Am Chem Soc 2002; 124:3865-74.

Green EL, Nakamura N, Dooley DM, Klinman JP, Sanders-Loehr J. Rates of oxygen and hydrogen exchange as indicators of TPQ cofactor orientation in amine oxidases. Biochemistry 2002; 41:687-696.

Dove JE, Klinman JP. Trihydroxyphenylalanine quinone (TPQ) from copper amine oxidases and lysyl tyrosylquinone (LTQ) from lysyl oxidase in Advances in Protein Chemistry: Novel Cofactors Vol 58, pp 141-174 (Dove J and Klinman JP, eds) Academic Press, California (2001).

Klinman JP. (2001) How many ways to craft a cofactor? Proc Natl Acad Sci USA 2001; 98:14766-14768.

Klinman JP. Life as aerobes: are there simple rules for activation of dioxygen by enzymes?J Biol Inorg Chem 2001; 6:1-13.

Knapp MJ, Seebeck FP, Klinman JP. Steric control of oxygenation regiochemistry in soybean lipoxygenase-1. J Am Chem Soc 2001; 123:2931-2932.

Schwartz B, Olgin AK, Klinman JP. The role of copper in topa quinone biogenesis and catalysis, as probed by azide inhibition of a copper amine oxidase from yeast. Biochemistry 2001; 40:2954-2963.

Schwartz B, Klinman, JP. Mechanisms of biosynthesis of protein-derived redox cofactors in Vitamins and Hormones Vol. 61, pp 219-39 (Begley, T and Schramm, VL, eds) Academic Press, California (2001).

Stahl SS, Francisco WA, Merkx M, Klinman JP, Lippard SJ. Oxygen kinetic isotope effects in soluble methane monooxygenase. J Biol Chem 2001; 276:4549-4553.

Tang C, Klinman JP. The catalytic function of bovine lysyl oxidase in the absence of copper. J Biol Chem 2001; 276:30575-78.

Thrower JS, Blalock R, Klinman JP. Steady-state kinetics of substrate binding and iron release in tomato ACC oxidase. Biochemistry 2001; 40:9717-9724.

Tsai SC, Klinman JP. Probes of hydrogen tunneling with horse liver alcohol dehydrogenase at subzero temperatures. Biochemistry 2001; 40:2303-2311.

Chen ZW, Schwartz B, Williams NK, Li RB, Klinman JP; Mathews, FS. Crystal structure at 2.5 angstrom resolution of zinc-substituted copper amine oxidase of Hansenula polymorpha expressed in Escherichia coli. Biochemistry 2000; 39:9709-9717.

Chin JK, Klinman JP. Probes of a role for remote binding interactions on hydrogen tunneling in the horse liver alcohol dehydrogenase reaction. Biochemistry 2000; 39:1278-1284.

Dove JE, Schwartz B; Williams NK, Klinman JP. Investigation of spectroscopic intermediates during copper-binding and TPQ formation in wild-type and active-site mutants of a copper-containing amine oxidase from yeast. Biochemistry 2000; 39:3690-3698.

Kohen A, Klinman JP. Protein flexibility correlates with degree of hydrogen tunneling in thermophilic and mesophilic alcohol dehydrogenases. J Am Chem Soc 2000; 122:10738-10739.

Melville CR, Green EL, Sanders-Loehr J, Klinman JP. Reassessment of the active site quino-cofactor proposed to occur in the Aspergillus niger amine oxidase AO-I from the properties of model compounds. Biochemistry 2000; 39:7589-7594.

Mills SA, Klinman JP. Evidence against reduction of Cu2+ to Cu+ during dioxygen activation in a copper amine oxidase from yeast. J Am Chem Soc 2000; 122:9897-9904.

Schwartz B, Dove JE, Klinman JP. Kinetic analysis of oxygen utilization during cofactor biogenesis in a copper-containing amine oxidase from yeast. Biochemistry 2000; 39:3699-3707.

Williams NK, Klinman JP. Whence topa? Models for the biogenesis of topa quinone in copper amine oxidases. J Mol Cat B-Enzymatic 2000; 8:95-101.

Hevel JM, Mills SA, Klinman JP. Mutation of a strictly conserved, active-site residue alters ssubstrate specificity and cofactor biogenesis in a copper amine oxidase.
Biochemistry 1999; 38:3683-3693.

Plastino J, Green EL, Sanders-Loehr J, Klinman JP. An unexpected role for the active site base in cofactor orientation and flexibility in the copper amine oxidase from Hansenula polymorpha. Biochemistry 1999; 38:8204-8216.

Su QJ, Klinman JP. Nature of oxygen activation in glucose oxidase from Aspergillus niger: The importance of electrostatic stabilization in superoxide formation. Biochemistry 1999; 38:8572-8581.

Kohen A, Cannio R, Bartolucci S, Klinman JP. Enzyme dynamics and hydrogen tunneling in a thermophilic alcohol dehydrogenase. Nature 1999; 399:496-499.

Rickert KW, Klinman JP. Nature of hydrogen transfer in soybean lipoxygenase 1: Separation of primary and secondary isotope effects. Biochemistry 1999; 38:12218-12228.

Rucker J, Klinman JP. Computational study of tunneling and coupled motion in alcohol dehydrogenase-catalyzed reactions: Implication for measured hydrogen and carbon isotope effects. J Am Chem Soc 1999; 12:1997-2006.

Colby TD, Bahnson BJ, Chin JK, Klinman JP, Goldstein BM. Active site modifications in a double mutant of liver alcohol dehydrogenase: Structural studies of two enzyme-ligand complexes. Biochemistry 1998; 37:9295-9304.

Francisco WA, Merkler DJ, Blackburn NJ, Klinman JP. Kinetic mechanism and intrinsic isotope effects for the peptidylglycine alpha-amidating enzyme reaction. Biochemistry 1998; 37:8244-8252.

Schwartz B, Green EL, Sanders-Loehr J, Klinman JP. Relationship between conserved consensus site residues and the productive conformation for the TPQ cofactor in a copper-containing amine oxidase from yeast. Biochemistry 1998; 37:16591-16600.

Su QJ, Klinman JP. Probing the mechanism of proton coupled electron transfer to dioxygen: The oxidative half-reaction of bovine serum amine oxidase. Biochemistry 1998; 37:12513-12525.

Kohen A, Klinman JP. Enzyme catalysis: Beyond classical paradigms. Accts Chem Res 1998; 31:397-404.

Francisco WA, Tian GC, Fitzpatrick PF, Klinman JP. Oxygen-18 kinetic isotope effect studies of the tyrosine hydroxylase reaction: Evidence of rate limiting oxygen activation. J Am Chem Soc 1998; 120:4057-4062.

Li RB, Klinman JP, Mathews FS. Copper amine oxidase from Hansenula polymorpha: the crystal structure determined at 2.4 angstrom resolution reveals the active conformation. Structure 1998; 6:293-307.