Tinoco Research Group

 

Department of Chemistry   University of California, Berkeley

 

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Welcome to Tinoco Group

 

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The sequence of nucleotides in a nucleic acid determines its structure and function;

Professor Tinoco and his students want to deduce these fundamental properties from the sequence.

 

Important questions are:

 

• What folded, base paired structure of an RNA is specified by the sequence?

 

• How do RNA loops interact with each other, or with double stranded regions to form compact three-dimensional structures?

 

• What proteins, drugs, and ions do these structures bind?

 

• How do the sequence and structure affect the functions of ribosomal RNA's, the sites of processing of RNA, the translation of messenger RNA's, the replication of RNA viruses, and the catalytic abilities of RNA enzymes?

 

Some general things about RNA: PDF  Audio 

 

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