IGNACIO TINOCO, Professor in the Graduate School

Chemistry Department, University of California, Berkeley, CA 94720-1460

EDUCATION:

B. S., University of New Mexico, 1951

Ph.D., University of Wisconsin, 1954

Postdoctoral Fellow, Yale University, 1954-56

PROFESSIONAL:

Faculty member, Department of Chemistry, University of California, Berkeley, 1956-present. Sixty one students received their Ph. D.; 62 postdoctorals have been trained.

Scientist, Lawrence Berkeley National Laboratory, 1961-present

Chairman, Department of Chemistry, University of California, Berkeley, 1979-82

Member, Health and Environmental Research Advisory Committee, DOE, 1986-90; Chairman, subcommittee on the Human Genome Initiative, DOE, 1986-87

California Council on Science and Technology, 1989-91, Fellow, 1992-present

HONORS:

Miller Research Professor, University of California, Berkeley, 1963

Guggenheim Fellow, MRC Lab. of Molecular Biology , Cambridge, England, 1964

California Section Award, American Chemical Society, 1965

D.Sc., University of New Mexico, 1972

Rosser-Rivera Distinguished Lecturer in Biological Chemistry, California State University, Los Angeles, and University of California, Riverside, 1983

Fellow, American Physical Society, 1984

Member, National Academy of Sciences, 1985

Fellow, California Academy of Sciences, 1988.

NIH MERIT Award, 1990-2000

Founders Award, Biophysical Society, 1996

Keynote speaker, Biopolymers Gordon Conference, 1996

Berkeley Citation, University of California, Berkeley, 1996

J. L. Oncley Lecturer, The University of Michigan, 1997

Pharmacia-Upjohn Lecturer, Indiana University, 1998

2000 Steenbock Lecturer, University of Wisconsin, 2000

Fellow, The Biophysical Society, 2000

Member, American Academy of Arts and Sciences, 2001

Emily Gray Award, Biophysical Society, 2006

Nucleic Acids Award Lecturer, Single Molecule Biology Meeting, Cambridge, England, 2006

Keynote speaker, Nucleic Acids Gordon Conference, 2007

EDITORIAL BOARDS AND SCIENTIFIC ORGANIZATIONS:

Editorial Boards:

Biopolymers, 1963 – present; Biochemistry, 1973 - 1977; 1988 - 1999.

Biophysical Chemistry, 1975 – 1999; Biochimica et Biophysica Acta, 1982 - 1992

Cell Biophysics, 1982 – 1994; Nucleic Acids Research, 1988 - 2000.

RNA, 1994 – 1996; Journal of Molecular Biology, 1995-2001. (Associate Editor)

PUBLICATIONS:

Co-author of a book on physical chemistry of nucleic acids, a textbook on biophysical chemistry (fourth edition), with Spanish and Japanese translations, and over 310 articles in scientific journals. The most recent are:

299. RNA Translocation and Unwinding Mechanism of HCV NS3 Helicase and its Coordination by ATP. S. Dumont, W. Cheng, V. Serebrov, I. Tinoco, Jr., A. M. Pyle, C. Bustamante, Nature, 439 105-108 (2006).

300. Probing the Mechanical Folding Kinetics of TAR RNA by Hopping, Force-Jump and Force-Ramp Methods. P. T. X. Li, D. Collin, S. B. Smith, C. Bustamante, I. Tinoco, Jr. Biophys. J., 90, 250-260 (2006).

301. Modeling RNA Unfolding Under Mechanical Tension. J. Vieregg, I. Tinoco, Jr., Molecular Physics, 104, 1343-1352 (2006).

302. Determination of Thermodynamics and Kinetics of RNA Reactions by Force, I. Tinoco, Jr. , P. TX. Li, C. Bustamante, Quart. Rev. Biophys. 39 (4), 1-36 (2006)

303. Unusual Mechanical Stability of a Minimal RNA Kissing Complex. P. TX. Li, C. Bustamante, I. Tinoco, Jr. Proc. Natl. Acad. Sci. USA. 103, 15847-15852 (2006).

304. Single molecule force unfolding kinetics of RNA. I. Experimental measurements using optical tweezers. J.-D. Wen, M. Manosas, P. TX. Li, S. B. Smith, C. Bustamante, F. Ritort, I. Tinoco, Jr., Biophys. J. , 92, 2996-3009 (2007).

305. Single molecule RNA force unfolding kinetics using optical tweezers. II. Modeling experiments, M. Manosas, J.-D. Wen, P. TX. Li, S. B. Smith, C. Bustamante, I. Tinoco, Jr., F. Ritort, Biophys. J. , 92, 3010-3021 (2007).

306. Real-Time Control of the Energy Landscape by Force Directs the Folding of Single RNA Molecules P. TX. Li, C. Bustamante, I. Tinoco, Jr., Proc. Natl. Acad. Sci. USA. 104, 7039-7044 (2007).

307. NS3 Helicase Actively Separates RNA Strands and Senses Sequence Barriers Ahead of the Opening Fork. W. Chen, S. Dumont, I. Tinoco Jr., C. Bustamante, Proc. Natl. Acad. Sci. USA. 104, 13954-13959 (2007). Editor's choice in Science 317, 1295 (2007).

308. Measurement of the Effect of Monovalent Cations on RNA Hairpin Stability. J. Vieregg, C. Bustamante, I. Tinoco, Jr., J. Am. Chem. Soc. 129, 14966-14973 (2007).

309. Single-Molecule Mechanical Unfolding and Folding of a Pseudoknot in Human Telomerase RNA. G. Chen, J.-D. Wen, I. Tinoco, Jr., RNA 13, 2175-2188 (2007).

310. Characterization of the Mechanical Unfolding of RNA Pseudoknots. L. Green, C.-H. Kim, C. Bustamante, I. Tinoco, Jr., J. Mol. Biol. 375, 511-528 (2008).

311. Following translation by single ribosomes one codon at a time. J.-D. Wen, L. Lancaster, C. Hodges, A.-C. Zeri, S. Yoshimura, H. F. Noller, C. Bustamante, I. Tinoco, Jr., Nature, 452, 598-603 (2008). News and Views in Nature Chemical Biology 4, 275 - 276 (2008).