Front Page







Curtis, R., Prausnitz, J.M., & H.W. Blanch, "Protein-protein and Protein-salt Interactions in Aqueous Protein Solutions Containing Concentrated Electrolytes", Biotech. Bioeng. 57 (1) 11-21 (1998) PDF

Mancuso, A; Sharfstein, S.T; Fernandez, E.J.; Clark, D.S. & H.W. Blanch, "Effect of extracellular glutamine concentration on primary and secondary metabolism of a murine hybridoma: An in vivo C-13 nuclear magnetic resonance study", Biotechnology & Bioengineering, 57 (2), 172-186 (1998). PDF

Beverung, C.J., Radke, C.J. & H.W. Blanch, "Adsorption dynamics of L-glutamic Acid Copolymers at a heptane/water Interface", Biophysical Chemistry, 70, 121-132 (1998) PDF

Sunada, W. & H.W. Blanch, "Microscopy of DNA in dilute polymer solutions", Biotechnology Progress, 14 (5) 766-772 (1998)PDF

Hickel, A., Radke, C.J., & H.W. Blanch, "Hydroxynitrile lyase adsorption at liquid/liquid interfaces", Journal of Molecular Catalysis B: Enzymatic, 216, (5) 348-354 (1998)

Tupy, M.J., Blanch, H.W. & C.J. Radke, "A Total Internal Reflection Spectrometer to Study Dynamic Adsorption Phenomena at Liquid Liquid Interfaces", Industrial and Engineering Chemistry, 37, (8) 3159-3168 (1998)

Middelberg, A.P.J., C.J. Radke, H.W. Blanch.  1998.  Influence of peptide adsorption on interfacial tension.  Proc. 2nd Eur. Symp. Biochem. Eng. Sci. (S. Feyo de Azevedo et al., eds), Porto, Portugal, 16-19 Sep. 1998, 147-150

Sunada, W.M., & H.W. Blanch, "A Theory for the Electrophoretic Separation of DNA in Polymer Solutions", Electrophoresis, 19, (18) 3128-3136 (1998).

Boyd, B.M., Prausnitz, J.M., & H.W. Blanch, "High frequency alternating-crossed-field gel electrophoresis with neutral or slightly charged interpenetrating networks to improve DNA separation", Electrophoresis, 19, (18) 3137-3148 (1998).



Kuehner, D.E., Engmann, J., Fergg, F., Wernick, M., Blanch, H.W., & J.M. Prausnitz, "Lysozyme Net Charge and Ion Binding in Concentrated Aqueous Electrolyte Solutions", J. Phys. Chem. B, 103, (8) 1368-1374 (1999)

Hickel, A., Radke, C.J. & H.W. Blanch, "Hydroxynitrile Lyase at the Diisopropyl Ether/Water Interface: Evidence for Interfacial Enzyme Activity", Biotech. Bioeng. 65, 425-436 (1999)

Beverung, C.J., Radke, C.J., & H.W. Blanch, "Protein adsorption at the oil/water interface: Characterization of adsorption kinetics by dynamic interfacial tension measurements", Biophysical Chemistry , 81 59-80 (1999)PDF

J.Z. Wu, D. Bratko, H.W. Blanch, J.M. Prausnitz, "Monte Carlo simulation from the potential of mean force between ionic colloids in solutions of asymmetric salts", J. Chem. Physics, 111, (15) 7084-7094 (1999)



Moon, Y.U., Anderson, C., Blanch, H.W., & J.M. Prausnitz, "Osmotic Pressures and Second Virial Coefficients for Aqueous Saline Solutions of Lysozyme", Fluid Phase Equilibria, 168, 229-239 (2000)

Grigsby, J.J., Blanch, H.W., & J.M.Prausnitz, "Diffusivities of Lysozyme in Aqueous MgCl2 Solutions from Dynamic Light Scattering Data: Effect of Protein and Salt Concentrations", J. Phys. Chem. B, 104, (15) 3645-3650 (2000)

Anderson, C.O., Niesen, J.F.M., Blanch, H.W. & J.M. Prausnitz, "Interactions of proteins in aqueous electrolyte solutions from fluorescence anisotropy and circular dichroism measurements", Biophysical Chemistry, 84, 177-188 (2000)

Reichmuth, D.S., Hittle, J.L., Blanch, H.W., & J.D.Keasling, "Biodesulfurization of dibenzothiophene in Escherichia coli is enhanced by the expression of Vibrio harveyi oxidoreductase gene", Biotechnol. Bioeng. 67, (1) 72-79 (2000)

Middelberg, A., Radke, C.J. & H.W. Blanch, "Peptide Interfacial Adsorption is Kinetically Limited by the Thermodynamic Stability of Self Association", PNAS, 97, (10) 5054-5059 (2000) PDF

Wu, J.Z., Bratko, D. Blanch, H.W., & J.M. Prausnitz, "Effects of three body forces on the phase behavior of charged colloids", J. Chem Phys. 113, (8) 3360-3365 (2000)

Forbes, N., Clark, D.S., & H.W. Blanch, "Analysis of Metabolic Fluxes in Mammalian Cells", in Bioreactor Engineering Volume 4; Reactions Involving Microorganisms and Cells. Modelling and Control, K. Schugerl & K. Bellgardt eds. Springer Verlag, Chap 17, p556-594 (2000)

Moon, Y.U., Curtis, R.S., Anderson, C.O., Blanch, H.W., & J.M. Prausnitz, "Protein-protein interactions in aqueous ammonium sulfate solutions. Lysozyme and bovine serum albumin (BSA)", J. Solution Chemistry, 29 (8) 699-717 (2000)

Prausnitz, J.M., Wu, J., Bratko, D., & H.W. Blanch, "Resolving a Mysterious Particle Attraction in Colloids", EnVision, 16, (4) 18-19 (2000)

Wu, J.Z., Bratko, D. Blanch, H.W., & J.M. Prausnitz, "Interactions between Oppositely Charged Micelles or Globular Proteins", Physical Review E, 62, (4) 5273-5280 (2000)



Bratko, D.B., & H.W. Blanch, "Competition between Protein Folding and Aggregation: A Three-Dimensional Lattice-Model Simulation", J. Chem. Phys. 114, 561 (2001) PDF

Curtis, R.A., Blanch, H.W., & J.M. Prausnitz, "Calculation of Phase Diagrams for Aqueous Protein Solutions", J. Phys. Chem. B, 105, 2445-2452 (2001) PDF

Hickel, A., Radke, C.J. & H.W. Blanch, "The Role of Organic Solvents on p-Hydroxynitrile Lyase Interfacial Activity and Stability", Biotech. & Bioeng. 74, 18-28 (2001) PDF

Cascao-Pereira, L., Johansson, C. Blanch, H.W., & C.J. Radke, "A Bike-Wheel Microcell for Measurement of Thin Film Forces", Colloids & Surfaces A, 186 (1-2), 103-111 (2001) PDF

Forbes, N.S., Clark, D.S., & H.W. Blanch, "Using Isotopomer Path Tracing to Quantify Metabolic Fluxes in Pathway Models Containing Reversible Reactions", Biotech & Bioeng, 74, (3) p196-211, (2001) PDF

Bratko, D., Curtis, R.A., Blanch, H.W., & J.M. Prausnitz, "Interaction Between Hydrophobic Surfaces with Metastable Intervening Liquid ", J. Chem. Phys. 115 (8), 3873-3877 (2001) PDF

Gentile, M-P., H.W. Blanch, "Pigment Content and Physiology of Nannochloropsis gaditana", Biotech. & Bioeng., 75, (1) 1-12 (2001)

Grigsby, J.J., Blanch, H.W. & J.M. Prausnitz, "Cloud Point Temperatures for Lysozyme in Electrolyte Solutions: Effect of Salt Type, Salt Concentration and pH", Biophysical Chemistry, 91, 231-243 (2001) PDF

Curtis, R.A., Newman, J.S., Blanch, H.W., & J.M. Prausnitz, "McMillan-Mayer Solution Thermodynamics for a Protein in a Mixed Solvent", Fluid Phase Equilibria, 192 (1-2), 131-153 (2001) PDF



Bratko, D.B., Striolo, A., Wu, Z., Blanch, H.W., & J.M. Prausnitz, "Orientation-Averaged Pair Potentials between Dipolar Proteins or Colloids", J. Phys. Chem. B, 106 (10), 2714-2720 (2002) PDF

Blanch, H.W., Prausnitz, J.M., Curtis, R.A., & D.B. Bratko, "Molecular thermodynamics and Bioprocessing: From Intracellular Events to Bioprocessing", Fluid Phase Equilibria, 4933, 1-11 (2002)

Luo, C., Brink, D.L. & H.W. Blanch, "Identification of Potential Inhibitors in Conversion of Poplar Hydrolyzate to Ethanol", Biomass & Bioenergy, 22 (2), 125-138 (2002)

Striolo, A., Bratko, D.B., Wu, J-Z., Elvassore, N., Blanch, H.W., & J.M. Prausnitz, "Forces Between Non-Uniformly Charged Colloids from Molecular Simulation", J. Chem. Phys. 116 (17) 7733-7743, (2002)

Cascao Pereira, L., Hickel, A., Radke, C.J., H.W. Blanch, "A Kinetic Model for Enzyme Interfacial Activity and Stability: pa-Hydroxynitrile Lyase at the Diisopropyl Ether/Water Interface", Biotech. Bioeng. 78 (6), 595-605 (2002) PDF

von Solms, N., Anderson, C.A., Blanch, H.W. & J.M. Prausnitz, "Molecular thermodynamics for Fluid-Phase Equilibria in Aqueous Two-protein Solutions", AIChE Journal 48 (6), 1292-1300 (2002)

Curtis, R.A., Ulrich, J., Montasser, A., Prausnitz, J.M., & H.W. Blanch, "Protein-protein Interactions in Concentrated Electrolyte Solutions: Hofmeister Series Effects", Biotech. Bioeng. 79 (4), 367- (2002) PDF

Kim, D., Blanch, H.W., & C.J. Radke, "Direct Imaging of Aqueous Lysozyme Adsorption onto Mica by Atomic Force Microscopy", Langmuir, 18(15), 5841-5850 (2002) PDF

Curtis, R.A., Steinbrecher, C., Heinemann, Blanch, H.W. & J.M. Prausnitz, "Hydrophobic Forces Between Protein Molecules in Aqueous Solutions of Concentrated Electrolyte", Biophysical Chemistry, 98 (3), 249-265 (2002)

Grigsby, J.J., H.W. Blanch & J.M. Prausnitz, "Effect of Secondary Structure on the Potential of Mean Force for Poly-L-Lysine in the a-Helix and b-Sheet Conformations", Biophysical Chemistry, 99, 107-116 (2002)



Bratko, D., & H.W. Blanch, "The Effect of Secondary Structure on Protein Aggregation: A Replica Exchange Simulation Study", J. Chem. Phys.,118 (11), 5185-5194 (2003)

Cascao-Pereira, L., Theolody, O., Blanch, H.W. & C.J. Radke, "Dilatational Rheology of BSA Conformers at the Air/Water Interface", Langmuir, 19(6) 2349-2356 (2003)

Cascao-Pereira, L., Hickel, A., Radke, C.J. & H.W. Blanch, "Interfacial versus Homogeneous Cleavage of Mandelonitrile by Hyroxynitrile Lyase in a Biphasic System", Biotechnology & Bioengineering, 83 (4), 498-501 (2003)

Ferree, S. & H.W. Blanch, "Electrokinetic Stretching of Tethered DNA", Biophys. J., 85 (4) 2539-2546 (2003) PDF

Cascao-Pereira, L., Johansson, C., Radke, C.J. & H.W. Blanch, "Surface Forces and Drainage Kinetics of Protein-Stabilized Thin Aqueous Films", accepted, Langmuir (2003)

Anderson, C.O., Spiegelberg, S., Prausnitz, J.M. & H.W. Blanch, "Effect of Secondary Structure on the Interactions of Peptide T4 LYS (11-36) in Mixtures of Aqueous Sodium Chloride and 2,2,2 Trifluoroethanol", Biophysical Chemistry, (submitted 2002)

Coen, C.J., Prausnitz, J.M., & H.W. Blanch, "Chloride binding affects lysozyme solubility", Biophys. Biochem. Acta, (submitted, (2002)

Wicklund, K.A., Blanch, H.W. & D.S. Clark, "Effects of Hypoxia on the Tamoxifen Response of MCF7 Human Breast Cancer Cells in Microcarrier Cultures", submitted to Cancer Research (2002)

Forbes, N., Clark, D.S. & H.W. Blanch, "Quantifying Cancer Metabolism: A Novel Approach to Drug Target Discovery", Nature Biotechnology (submitted 2002)

Anderson, C.A., Prausnitz, J.M. & H.W. Blanch, "Interactions of proteins in Ammonium Sulfate Solutions: Mixtures of Lysozyme and Ovalbumin", Biophysical Chemistry (submitted 2002)

Luo, C., Brink, D.L., & H.W. Blanch, "Butanol Extraction of Hybrid Poplar Hydrolyzate to Improve Fermentabillity of Wood sugars to Ethanol", J. Applied Microbiol. (submitted 2002)

Lui, W., Bratko, D., Prausnitz, J.M. & H.W. Blanch, "Electrostatic Interactions between Peptides and the Molecular Chaperone DnaK", J. Phys. Chem. (accepted 2003)

Striolo, A.,Tavares, F. W., Bratko, D., Blanch, H. W. & J. M. Prausnitz, "Analytic Calculation of Phase Diagrams for Charged Dipolar Colloids with Orientation-Averaged Pair Potentials", Phys. Chem. Chem. Phys. (accepted 2003)

Teske, C.A., Blanch, H.W., & J.M. Prausnitz, "Chromatographic measurements of interactions between unlike proteins", J. Phys. Chem. (submitted 2003)

Teske, C.A., Blanch, H.W., & J.M. Prausnitz, "Measurement of lysozyme-lysozyme interactions with quantitative chromatography" Fluid Phase Equilibria (submitted 2003)

Lui, W., Bratko, D., Prausnitz, J.M. & H.W. Blanch, "Effect of alcohols on aqueous lysozyme-lysozyme interactions from static light scattering measurements", submitted Biophys. Chem. (2003)



Lui, W., Bratko, D., Prausnitz, J.M. & H.W. Blanch, "Effect of alcohols on aqueous lysozyme-lysozyme interactions from static light scattering measurements", Biophys. Chem. 107 (3) 289-298 (2004)

Kim, D. T.; Blanch, H. W.; Radke, C. J. Protein Adsorption Studied by Atomic Force Microscopy. In Dekker Encyclopedia of Nanoscience and Nanotechnology, James A. Schwarz, Cristian I. Contescu, and Karol Putyera, Eds.; Marcel Dekker, Inc.: New York, 2004; pp 3041-3064.

Tavares, F.W., Bratko, D., Striolo, A., Blanch, H.W. & J.M. Prausnitz, "Phase behavior of aqueous solutions containng dipolar proteins from second-order perturbation theory", J. Chem. Phys., 120 (20) 9859-9869 (2004)

Teske, C.A., Blanch, H.W., & J.M. Prausnitz, "Chromatographic measurements of interactions between unlike proteins", Fluid Phase Equilibria, 219, 139-148 (2004)

Teske, C.A., Blanch, H.W., & J.M. Prausnitz, "Measurement of lysozyme-lysozyme interactions with quantitative affinity chromatography", J. Phys. Chem. B, 108, 7437-7444 (2004)

Ferree, S. & H.W. Blanch, "The Hydrodynamics of DNA Electrophoretic Stretch and Relaxation in a Polymer Solution", Biophys. J., 87, 468-475 (2004)

Tavares, F.W., Bratko, D.N., Blanch, H.W., Prausnitz, J.M., "Ion-specific effects in the colloid-colloid or protein-protein potential of mean force: Role of salt-macroion van der Waals interactions", J. Phys. Chem. B, 108, 9228-9235 (2004)

Wendorf, J. Radke, C.J., & H.W. Blanch, "Reduced Protein Adsorption by Sugar Excipients at Solid Interfaces", Biotech. Bioeng. 87 (5) 565-573 (2004)

Lui, W., Prausnitz, J.M., & H.W. Blanch, "Amyloid Fibril Formation by Peptide LYS (11-36) in Aqueous Trifluoroethanol", Biomacromolecules, 5, 1818-1823 (2004)

Reichmuth, David S., Blanch, Harvey W., Keasling, Jay D, "Dibenzothiophene biodesulfurization pathway improvement using diagnostic GFP fusions", Biotech & Bioeng., 88 (1),94-99 (2004)



Cellmer, T., Bratko, D.N., Prausnitz, J.M., Blanch, H.W., "The competition between protein folding and aggregation: Off-lattice minimalist model studies", Biotech & Bioeng. 89 (1) 78-89 (2005)

Voogt, J. & H.W. Blanch, _Temperature Induced Solvate Disruption of Guanidinium-1,5-Naphthalendisulfonate Networks Yields a One-Dimensional Pore Structure", Crystal Growth and Design, 5 (3) 1135-1144 (2005)

David T. Kim, Harvey W. Blanch, and Clayton J. Radke, "Imaging of Reconstituted Purple Membranes by Atomic Force Microscopy", Colloids and Surfaces B: Biointerfaces, 41 (4), 263-276 (2005)

Cellmer, T., Bratko, D.N., Prausnitz, J.M., Blanch, H.W., "Thermodynamics of folding and association of lattice-model proteins", J. Chem. Phys. 122 (17), 174908 (2005)

Wei Liu, Troy Cellmer, David Keerl, John M. Prausnitz, and Harvey W. Blanch, "Interactions of lysozyme in guanidinium chloride solution from dynamic light scattering measurements", Biotechnology & Bioengineering 90 (4), 482-490 (2005)

Cellmer, Troy, Bratko, Dusan, Prausnitz, John, Blanch, Harvey, "Protein Folding Landscapes in Multichain Systems", PNAS (accepted 2005)

Voogt, Jason, Blanch, Harvey, "Separation of Polyunsaturated Fatty Acids by Selective Inclusion in Guanidinium-1,5-naphthalenedisulfonate-2-methoxyethanol Networks" Biotech & Bioeng (accepted 2005)

Hsiao, T., Blanch, H.W., "Physiological Study of Polyunsaturated Fatty Acid Production in the Marine Microalga Glossomastix chrysoplasta", Biotech. Bioeng. (accepted 2005)

Hsiao, T., Blanch, H.W., "Identification of Delta-6 Desaturase from the marine microalga G. chrysoplasta and its functional analysis in S. cerevisiae" (J. Phycology, submitted 2005)