Science

The Williams group develops methods, instrumentation, and theory in mass spectrometry, separations, spectroscopy, and biophysics with the general goals of understanding the structure, reactivity, and function of biomolecules.

Recent Publications

  • Jordan, J. S.; Williams, E. R. Dissociation of Large Gaseous Serine Clusters Produces Abundant Protonated Serine Octamer. Analyst, 2021. [Web]
  • Jordan, J. S.; Williams, E. R. Effects of Electrospray Droplet Size on Analyte Aggregation: Evidence for Serine Octamer in Solution. Anal. Chem. 2021, 93, 1725–1731. [Web]
  • Harper, C. C.; Brauer, D. D.; Francis, M. B.; Williams, E. R. Direct Observation of Ion Emission from Charged Aqueous Nanodrops: Effects on Gaseous Macromolecular Charging. Chem. Sci. 2021. [Web]
  • Stachl, C. N.; Williams, E. R. Effects of Temperature on Cs+(H2O)20 Clathrate Structure. J. Phys. Chem. Lett. 2020, 11, 6127–6132. [Web]
  • Karandu, D.; Bhattacharyya, M.; Xia, B.; Lee, Y. K.; Muratciuglu, S.; McAffee, D.; McSpadden, E. D.; Qiu, B.; Groves, J.; Williams, E. R.; Kuriyan, J. Breakage of the Oligomeric CaMKII Hub by the Regulatory Segment of the Kinase. eLife 2020, 9:e57784. [Web]
  • Harper, C.C.; Williams, E. R. Enhanced Multiplexing in Fourier Transform Charge Detection Mass Spectrometry by Decoupling Ion Frequency from Mass to Charge Ratio. J. Am. Soc. Mass Spectrom. 2019, 30, 2637–2645. [Web]
  • Harper, C.C.; Elliott, A.G.; Oltrogge, L. M.; Savage, D. F.; Williams, E. R. Multiplexed Charge Detection Mass Spectrometry for High Throughput Single Ion Analysis of Large Molecules. Anal. Chem. 2019, 91, 7458–7465. [Web]
  • McSpadden, E. D.; Xia, Z.; Chi, C. C.; Susa, A. C.; Shah, N. H.; Gee, C. L.; Williams, E. R. Variation in Assembly Stoichiometry in Non-metazoan Homologs of the Hub Domain of Ca2+/Calmodulin-dependent Protein Kinase II. Protein Science. 2019, 28, 1071–1082. [Web]
  • Xia, Z.; DeGrandchamp, J. B.; Williams, E. R. Native mass spectrometry beyond ammonium acetate: effects of nonvolatile salts on protein stability and structure. Analyst. 2019, 144, 2565–2573. [Web]
  • Xia, Z.; Williams, E. R. Effect of Droplet Lifetime on Where Ions are Formed in Electrospray Ionization. Analyst. 2019, 144, 237–248. [Web]
  • Elliott, A.G.; Harper, C.C.; Lin, H.-W.; Williams, E. R. Effects of Individual Ion Energies on Charge Measurements in Fourier Transform Charge Detection Mass Spectrometry. J. Am. Soc. Mass Spectrom. 2019, 30, 946–955. [Web]
  • Kenderdine, T.; Xia, Z.; Williams, E. R. Fabris, D. Submicrometer Nanospray Emitters Provide New Insights into the Mechanism of Cation Adduction to Anionic Oligonucleotides. Analyst. 2018, 90, 13541–13548. [Web]
  • Harper, C.C.; Elliott, A.G.; Lin, H.-W.; Williams, E. R. Determining Energies and Cross Sections of Individual Ions Using Higher-Order Harmonics in Fourier Transform Charge Detection Mass Spectromemetry (FT-CDMS). J. Am. Soc. Mass Spectrom. 2018, 29, 1861–1869. [Web]
  • Susa, A. C.; Lippens, J. L.; Xia, Z.; Loo, J. A.; Campuzano, D. G.; Williams, E. R. Submicrometer Emitter ESI Tips for Native Mass Spectrometry of Membrane Proteins in Ionic and Nonionic Detergents. J. Am. Soc. Mass Spectrom. 2017, 29, 203–206. [Web]
  • Xia, Z.; Williams, E. R. Protein-Glass Surface Interactions and Ion Desalting in Electrospray Ionization with Submicron Emitters. J. Am. Soc. Mass Spectrom. 2017, 29, 194–202. [Web]
  • Susa, A. C.; Xia, Z.; Williams, E. R. Native Mass Spectrometry from Common Buffers with Salts That Mimic the Extracellular Environment. Angew. Chem. Int. Ed. 2017, 56, 7912–7915. [Web]
  • Thaunay, F.; Hassan, A. A.; Cooper, R. J.; Williams, E. R.; Clavaguera, C.; Ohanessian, G. Hydration of the sulfate dianion in size-selected water clusters: From SO42-(H2O)9 to SO42-(H2O)13 Int. J. Mass Spectrom. 2017, 418, 15–23. [Web]
  • Elliott, A. G.; Harper, C. C.; Lin, H.-W.; Susa, A. C.; Xia, Z.; Williams, E. R. Simultaneous Measurements of Mass and Collisional Cross-Section of Single Ions with Charge Detection Mass Spectrometry. Anal. Chem. 2017, 89, 7701–7708. [Web]
  • Elliott, A. G.; Harper, C. C.; Lin, H.-W.; Williams, E. R. Mass, Mobility and MSn of Single Ions Using Charge Detection Mass Spectrometry Analyst. 2017, 142, 2760–2769. [Web]
  • Elliott, A. G.; Merenbloom, S. I.; Chakrabarty, S.; Williams, E. R. Single Particle Analyzer of Mass: A Charge Detection Mass Spectrometer with a Multi-Detector Electrostatic Ion Trap Int. J. Mass Spectrom. 2017, 414, 45–55. [Web]
  • DiTucci, M. J.; Böhm, F.; Schwaab, G.; Williams, E. R.; Havenith, M. Effects of Multivalent Hexacyanoferrates and Their Ion Pairs on Water Molecule Dynamics Measured with Terahertz Spectroscopy Phys. Chem. Chem. Phys. 2017, 19, 7297–7306. [Web]
  • Susa, A. C.; Xia, Z.; Williams, E. R. Small Emitter Tips for Native Mass Spectrometry of Proteins and Protein Complexes from Nonvolatile Buffers That Mimic the Intracellular Environment Anal. Chem. 2017, 89, 3116–3122. [Web]
  • Heiles, S.; Cooper, R. J.; DiTucci, M. J.; Williams, E. R. Sequential Water Molecule Binding Enthalpies for Aqueous Nanodrops Containing a Mono-, Di- or Trivalent Ion and Between 20 and 500 Water Molecules Chem. Sci. 2017, 8, 2973–2982. [Web]
  • Susa, A. C.; Xia, Z.; Tang, H. Y. H.; Tainer, J. A.; Williams, E. R. Charging of Proteins in Native Mass Spectrometry J. Am. Soc. Mass Spectrom. 2017, 28 332–340. [Web]
  • DiTucci, M. J. and Williams, E. R. Nanometer Patterning of Water by Tetraanionic Ferrocyanide Stabilized in Aqueous Nanodrops Chem. Sci. 2017, 81391–1399. [Web]

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    Last updated Feb 12th, 2018

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