Cheng-Chun Peng

Postdoctoral Fellow

University of Florida, Gainesville, FL.
Ph.D. in Chemical Engineering, 2011

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National Taiwan University, Taipei, Taiwan.
M.S. in Chemical Engineering, 2005

B.S. in Chemical Engineering, 2003

 

Research Interests:

  • Surface interaction and transport phenomena for the safety of contact lens wear
  • Mathematical modeling of tear dynamics for drug delivery
  • Extended ocular drug delivery by contact lenses

 

Web Pic_Peng
“Stadiums are so much more exciting when they’re empty!”

 

chengchunpeng@gmail.com

Radke Lab Home PageGroup MembersSeminarPublications

  • Surface Interaction and Transport Phenomena for the Safety of Contact Lens Wear

The safety of extended-wear contact lenses is determined by the interaction between the contact lens material and the physiologic conditions of precorneal tear-film. For example, oxygen diffusion through the hydrogel matrix of contact lens is critical for the health of corneal epithelium cells; ion transport through the lens material changes the stability of post-lens tear film and the on-eye movement of the lens. Lipid and protein depositions on the lens surface increase not only the discomfort of contact lens wear, but more importantly, the risk of bacterial infections as well. Establishment of the mechanisms for these phenomena is critical for future contact lens design.

 

 


  • Mathematical Modeling of Tear Dynamics for Drug Delivery

The majority of topically applied ocular drugs mixed in the precorneal tear-film before it potentially reach the target tissues. The bioavailability of these drugs is significantly determined by the transient drug distribution in the precorneal tear-film, and other complicated clearance mechanisms. We try to establish a dynamic model to predict the stability of the tear-film and dynamic tear distribution in blink cycles, and thus predict dynamic drug distribution by various drug administration methods.

 

 


  • Extended Ocular Drug Delivery by Contact Lenses

Extended ocular drug delivery can be achieved by introducing compatible diffusion barriers into silicone hydrogel contact lenses. These diffusion-barrier loaded contact lenses can provide sustained drug release up to a few weeks. In addition, these lenses are characterized to satisfy all criteria, such as oxygen and ion permeability, elastic modules, transparency, etc., to be safely worn continuously during the desired drug release period. Such a device can significantly enhance the drug delivery efficiency and improve patient compliance for treatment of common chronic ocular diseases, such as glaucoma and dry eye.

 

 

 

Publications:

  • C. -C. Peng, C. Cerretani, R. J. Braun, C. J.Radke, “Evaporation-Driven Instability of the Precorneal Tear Film”, Advances in Colloid and Interface Science, (2013) accepted

  • C. Cerretani, C. -C. Peng, A. Chauhan, C. J. Radke, “Aqueous salt transport through soft contact lenses: An osmotic-withdrawal mechanism for prevention of adherence”, Contact Lens and Anterior Eye, 35 (2012) 260-265

  • C. -C. Peng, M. T. Burke, B. E. Carbia, C. Plummer, A. Chauhan, “Extended Drug Delivery by Contact Lenses for Glaucoma Therapy”, Journal of Controlled Release, 162 (2012) 152-158

  • C. -C. Peng, A. Chauhan, “Ion transport in silicone hydrogel contact lenses”, Journal of Membrane Science, 399-400 (2012) 95-105

  • C. -C. Peng, A. Ben-Sholmo, E. MacKay, C. E. Plummer, A. Chauhan, “Drug delivery by contact lens in spontaneously glaucomatous dogs”, Current Eye Research, 37 (2012) 204-211

  • C. -C. Peng, M. T. Burke, A. Chauhan, “Transport of topical anesthetics in vitamin E loaded silicone hydrogel contact lens”, Langmuir, 28 (2012) 1478-1487

  • C. -C. Peng, A. Chauhan, “Extended Cyclosporine Delivery by Silicone-Hydrogel Contact Lenses”, Journal of Controlled Release, 154 (2011) 267-274

  • C. -C. Peng, L. C. Bengani, J. Leclerc, C. Gupta and A.Chauhan, “Emulsions and microemulsions for ocular drug delivery”, Journal of Drug Delivery Science and Technology, 21 (2011) 111-121

  • J. Kim, C. -C. Peng, A. Chauhan, “Extended release of dexamethasone from silicone-hydrogel contact lens containing Vitamin E”, Journal of Controlled Release, 148 (2010) 110-116

  • C. -C. Peng, J. Kim, A. Chauhan, “Extended delivery of hydrophilic drugs from silicone-hydrogel contact lenses containing Vitamin E diffusion barriers”, Biomaterials, 31 (2010) 4032-4047

 

Conference Abstract/Proceedings

  • C. -C. Peng, C. J. Radke, “Topical Ophthalmic Drug Delivery”, 87th ACS Colloid and Surface Science Symposium, University of California Riverside, Riverside, CA, Jun 25, 2013

  • C. -C. Peng, N. P. Fajardo, C. J. Radke, “In-Vitro Spoliation of Silicone Hydrogel Soft Contact Lenses”, 87th ACS Colloid and Surface Science Symposium, University of California Riverside, Riverside, CA, Jun 24, 2013

  • T. Razunguzwa, H. Goodman, C. -C. Peng, N. P. Fajardo, C. J. Radke, “In-Vitro Spoliation of SiHy Soft Contact Lenses using LAESI and FCSLM”, 2013 ARVO annual meeting, Washington State Convention Center, Seattle, WA, May 9, 2013

  • C. -C. Peng, B. Tan, M. C. Lin, C.. J. Radke, “Black-Spot Formation and Fluorescence Tear Break-Up Time”, 2013 ARVO annual meeting, Washington State Convention Center, Seattle, WA, May 5, 2013

  • C. -C. Peng, C. Cerretani, C. J. Radke, “Model for evaporation of the precorneal tear film including osmotic effects”,86th ACS Colloid and Surface Science Symposium, Johns Hopkins University, Baltimore, MD, Jun 13, 2012

  • C. -C. Peng, J. Kim, M. T. Burke, A. Chauhan, “Vitamin E loaded contact lenses for extended ophthalmic drug delivery”, 16th ISCLR symposium, Silverado Resort and Spa, Napa, CA, Aug. 21, 2011.

  • C. -C. Peng, A. Chauhan, "Extended Ophthalmic Drug Delivery by Silicone Contact Lens Containing Vitamin E", 12th Annual Graduate Association of Chemical Engineers Graduate Symposium, University of Florida, Gainesville, FL, Feb. 22, 2011

  • C. -C. Peng, A. Chauhan, “Cyclosporin A delivery by commercial contact lenses for chronic dry eye treatment” 2010 AIChE annual meeting, Hilton, Salt Lake City, UT, Nov. 12, 2010.

  • C. -C. Peng, J. Kim, A. Chauhan, “Vitamin E loaded contact lenses for extended ophthalmic drug delivery” 2010 AIChE annual meeting, Salt Palace Convention Center, Salt Lake City, UT, Nov. 11, 2010.

  • C. -C. Peng, A. Chauhan, “Effect of composition on ion permeability of silicone hydrogels as extend-wear contact lens” 2010 AIChE annual meeting, Salt Palace Convention Center, Salt Lake City, UT, Nov. 11, 2010.

  • C. -C. Peng, J. Kim, A. Chauhan, “Extended delivery of ophthalmic drugs by contact lenses containing nanobarriers of vitamin E”, ACS 239th national meeting, San Francisco, CA, Mar 21-25, 2010

  • C. -C. Peng, J. Kim, A. Chauhan, “Extended Ophthalmic Drug Delivery by Silicone-Hydrogel Contact Lenses”, 2009 AIChE annual meeting, Gaylord Opryland Hotel, Nashville, TN, Nov. 12, 2009.

  • C. -C. Peng, A. Chauhan, "Extended ophthalmic drug delivery from silicone-hydrogel contact lenses with diffusion barriers", 10th Annual Graduate Association of Chemical Engineers Graduate Symposium, University of Florida, Gainesville, FL, Feb. 17, 2009

 

 

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