Research Interests

Chemical Biology and Inorganic Chemistry

Our laboratory studies the chemistry of biology and energy. We advance new concepts in imaging, proteomics, drug discovery, and catalysis by drawing from core disciplines of inorganic, organic, and biological chemistry. For example, we have developed activity-based sensing as a general platform to identify transition metals, reactive oxygen species, and one-carbon units as new classes of single-atom signals for allosteric regulation of protein function. These chemical tools also reveal unique metal and redox disease vulnerabilities as targets for innovative drug discovery efforts to treat neurodegeneration, cancer, and metabolic disorders. Our work in artificial photosynthesis addresses global challenges in climate change. We use design concepts from biology to develop molecular electrocatalysts for carbon dioxide capture and conversion and nitrogen/phosphorus cycling. Representative project areas are summarized below.


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Transition Metal Signaling

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Activity-Based Sensing

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Activity-Based Proteomics

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Artificial Photosynthesis

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News


Fri November 3, 2023
Our recent study on the regulation of S-adenosylmethionine biosynthesis and one-carbon metabolism by formaldehyde was published in Science! Congrats to Vanha and Kevin. Read it here!
Tue July 25, 2023
We are excited to share our newly published paper on electrochemical nitrate reduction catalyzed by cobalt porphyrin organic cages for ammonia electrosynthesis in water. Read it here. Congrats to Lun, Mina, Peter and Paty!
Tue June 6, 2023
Farewell to Eva! She has completed her postdoc with us and will be starting her career as an assistant professor at the University of North Carolina, Charlotte. We wish you all the best!
Mon June 5, 2023
Congratulations to Mina, a postdoc in the inorganic subgroup, who will be starting his industry career at Dow in Michigan next month. Good luck!
Tue May 30, 2023
This month we bid farewell to our postdoc Marco. He is starting his independent career at the University of Delaware. Congratulations! Check out Marco's lab here.
Wed May 17, 2023
Congratulations to Paty for completing her PhD and starting her new job at the California Energy Commission in Sacramento. We wish her all the best!
Wed March 29, 2023
Congrats to Luke for receiving the NSF GRFP fellowship!
Mon March 13, 2023
We are excited to share that our second-year students Aila, Luke and Jayde have all passed their qualifying exams this year, officially making them PhD candidates.
Wed Feb 15, 2023
Congrats to Vanha on her review on metalloallostery and transition metal signaling. Read it here!
Mon Jan 2, 2023
Congratulations to Lun, Paty, and Mina on their study on synergistic porosity and charge effects for photochemical CO2 reduction appearing in Angewandte Chemie!
Fri Dec 9, 2022
Congrats to Angel, Audrey, and collaborators in the Toste group and Novartis on their paper using ReACT to discover and drug new methionine redox sites that crosstalk with phosphorylation in the high-value cancer drug target CDK4 appearing in JACS!
Thur Oct 20, 2022
Congratulations to Aidan and former post-doc Carson, as well as our collaborators Brady, DeNicola and Su, on their newly published PNAS paper on oxidation state-specific copper sensors. Read it here!
Tues Sept 13, 2022
Welcome to our lab Satoshi and Gen!
Tues May 17, 2022
Happy graduation to Jeff and Audrey! Best wishes in your next endeavors.
Sat May 14, 2022
Congrats to Audrey and Logan for winning best poster prizes at Chemical Biology in the Bay Area Day! And a great talk by Vanha.
Mon May 9, 2022
Welcome Jayde to our lab after first-year rotations. Best wishes with your PhD work!
Thurs Apr 28, 2022
Eva presented at the Chemical Biology and Physiology conference at OHSU. Great work!
Wed Mar 23, 2022
Congrats to Audrey for an awesome talk and to Vanha for the best poster prize at the MCB departmental BBS retreat.
Wed Mar 2, 2022
Congratulations to Logan and Abby for passing their qualifying exams!
Mon Nov 29, 2021
We welcome chembio student Soren to our lab. Happy rotation!
Fri Nov 12, 2021
Check out Eva's recently published Nature Reviews on copper and cancer. Congrats!
Mon Oct 18, 2021
We're excited to welcome inorganic graduate students Aila and Luke!
Wed Sept 15, 2021
We welcome rotation student Jayde to the lab!
Wed July 28, 2021
Congrats to Shang for his paper on his microtubule-localizing H2O2 probe!
Sat May 15, 2021
Congratulations to our undergraduate seniors Alan, Kaede, and Rachel on your graduation! Looking forward to seeing the great things you do.
Mon May 10, 2021
Welcome to first-year ChemBio grad student Abby to the lab! We're excited to have you with us.
Tues Feb 23, 2021
Congratulations to Hide and Marco on their new PNAS paper on imaging transcellular peroxide signaling.
Tues Dec 15, 2020
Zeming's paper on his potassium sensor RPS-1 has been published in Chemical Science.
Fri Nov 20, 2020
Check out Jeff's recently published paper on metal–ligand cooperativity for electrocatalysis!
Mon Nov 9, 2020
We welcome first-year grad student Logan to our lab!
Mon Sept 29, 2020
Check out Joel and Steven's paper that was recently published in PNAS, featuring a mechanistic study comparing two RNA demethylation pathways.
Thurs Sept 10, 2020
Congrats to our former PhD student Eva on accepting a faculty position at UBC! Check out Eva's lab website.
Tues Sept 8, 2020
Congrats to our former postdoc Clive on starting a faculty position at University of Hong Kong! Check out Clive's staff page.
Tues Sept 1, 2020
Check out our new CO activity-based sensing paper that was published in JACS.
Fri Aug 28, 2020
Congrats to Kevin for finishing his PhD, and best of luck in your postdoc with the Bertozzi group at Stanford!

Congrats to Peter for finishing his PhD, and best of luck in your postdoc with the Mirkin group at Northwestern!
Thurs Aug 20, 2020
Sumin and Clive's paper on activity-based sensing using a copper-directed acyl imidazole strategy appeared in JACS. This work was done in collaboration with the Miller, Saijo, and Hamachi labs.
Wed May 6, 2020
Congratulations to Jun on accepting a faculty position at North Carolina State. Check out Jun's new group website.
Congratulations to Diana on accepting a faculty position at Virginia Tech! Take a look at Diana's intro video for Virginia Tech, and check out Diana's faculty page.
Tues May 5, 2020
We're excited to welcome Angel to our lab! Congrats on completing your lab rotations and officially joining us!
Thur Mar 12, 2020
For prospective students with canceled visit weekends, please feel free to reach out to anyone in the lab if you would like more information. Emails are listed under the Current Members section. Check out our new virtual lab tour to see the lab!
Tues Jan 7, 2020
Peter's paper appeared in Angew. Chemie. The work was done in collaboration with the Kim lab.
Tues Jan 7, 2020
Jun and Lakshmi's paper appeared in ACS Central Science. The work was done in collaboration with the Miller and Toste labs.
Thur Sept 5, 2019
Jun and Kevin's review appeared in Acc. Chem. Res.
Thur Sept 5, 2019
Congratulations to Shang for finishing his PhD, and best of luck in your postdoc with the Sletten Group at UCLA!
Thur Aug 29, 2019
Clive and Sumin's paper appeared in PNAS. The work was done in collaboration with the Brady lab.
Mon Aug 5, 2019
Alec and Shang's paper appeared in JACS. The work was a collaboration with the Sigman and Toste labs.
Tue July 2 2019
Congratulations to Tim on accepting a faculty position at UC Riverside! Check out his lab website.
Mon June 17 2019
Tim and Kevin's review appeared in Curr. Opin. Biotechnology
Fri June 7 2019
Diana and Shang's review appeared in Inorg. Chem.
Thur June 6 2019
Sumin's paper appeared in Chem. Sci. The work was done in collaboration with the Long lab.
Wed June 5 2019
Congratulations to Ming on accepting a faculty position at Fudan University!
Thur May 16 2019
Tim and Marie's paper appeared in Cancers.The work was done in collaboration with the Toietta lab.
Wed April 24 2019
Shang's paper appeared in JACS.
Tues February 12 2019
The lab welcomes visitng scholar Tri and two chemical biology rotation students: Eli and Sarah!
Tues February 12 2019
Congratulations to Byungsun on accepting a faculty position at the Korean Institute of Science and Technology!
Thurs November 15 2018
The lab welcomes new graduate student Paty and three chemical biology rotation students: Naiya, Paul, and Rei Chi!
Tue October 23 2018
Tim's paper was highlighted in JACS Spotlights.
Tue October 16 2018
Tim's paper appeared in JACS. The work was done in collaboration with the Stahl lab.
Tue October 16 2018
Marie's collaboration with the Skaar lab appeared in Infection and Immunity.
Tue August 14 2018
Congratulations to Zhi on accepting a faculty position at the Institute of Coal Chemistry, Chinese Academy of Sciences!
Tue August 14 2018
Congratulations to Zeming for finishing his PhD, and best of luck in your postdoc with the Cohen Group at LBNL!
Tue August 14 2018
Congratulations to Sumin for finishing her PhD, and best of luck in your postdoc with the Bogyo Group at Stanford!
Fri July 27 2018
Tong's paper was featured in a HWNI article.
Mon July 9 2018
Peter's paper appeared in Angew. Chem. Int. Ed. The work was done in collaboration with the Kim lab.
Tues July 3 2018
Eva's paper appeared in Organometallics.
Wed June 27 2018
Congratulations to Allegra for finishing her PhD, and best of luck in your postdoc with the Dorrestein Group at UCSD!
Thurs June 14 2018
Lakshmi's viewpoint appeared in Biochemistry.
Tues June 12 2018
Tong's paper was featured in a C&E News article.
Wed June 6 2018
Tong's paper appeared in Nat. Chem. Biol. The work was done in collaboration with the Isacoff lab.
Thur May 3 2018
Clive's paper appeared in J. Am. Chem. Soc. The work was done in collaboration with the Saijo lab.
Mon April 16 2018
Kevin and Tim's paper appeared in Angew. Chemie. Int. Ed. The work was done in collaboration with the Shabat lab.
Thurs Mar 8 2018
Cheri's paper appeared in Metallomics The work was done in collaboration with the Weber and Pett-Ridge labs.
Wed Mar 5 2018
Zhi and Jeff's paper appeared in Angew. Chemie. Int. Ed. The work was done in collaboration with the Coperet and Wen labs.
Wed Feb 21 2018
Eva and Jeff's paper appeared in Chem. Sci.
Wed Jan 17 2018
Allegra and Audrey's review appeared in Curr. Opin. Chem. Biol
Tue Jan 2 2018
Allegra's collaboration appeared in eLIFE. The work was done in collaboration with the Renslo, Monje, and Wang labs.
Fri Dec 1 2017
Congratulations to Eva for finishing her PhD, and best of luck in your postdoc with the Mayer Group at Yale!
Fri Dec 1 2017
Congratulations to Shixian on accepting a faculty position at Zhejiang University!
Tue Nov 14 2017
Allegra and Marie's paper appeared in PNAS. The work was done in collaboration with the Skaar lab at Vanderbilt University and the Stahl lab at UC Berkeley.
Wed Oct 13 2017
Congratulations to Cheri for finishing her PhD, and best of luck in your postdoc at the Broad Institute in the Blainey Lab!
Thurs Sep 13 2017
Ming, Zhi, and Wei's paper appeared in ACS Central Science.
Thurs Aug 17 2017
Thom's collaboration with the KJ Patel Lab appeared in Nature.
Mon Aug 14 2017
The lab welcomes three new postdoctoral researchers: Byungsun, Diana, and Joel!
Wed Jul 19 2017
The website has been updated to be mobile friendly.
Tues Jun 28 2017
Congratulations to Marie for accepting a faculty position at UC Davis!
Tues Jun 27 2017
Congratulations to Wei for accepting a faculty position at Miami University of Ohio!
Fri Jun 2 2017
The lab welcomes Wendy, a visiting Amgen scholar for the summer from Cornell!
Mon May 29 2017
Kevin and Thom's review appeared in Current Opinion in Chemical Biology.
Mon May 29 2017
Congratulations to Thom for finishing his PhD, and best of luck in your postdoc at Princeton in the Macmillan Lab!
Thu April 13 2017
Congratulations to Chris, who has been elected into the American Academy of Arts and Sciences.
Fri April 7 2017
Thom's paper appeared in Chemical Science. The work was done in collaboration with the K. J. Patel lab at the University of Cambridge.
Tues April 4 2017
Kevin, Ryan, and Thom's paper appeared in the Journal of the American Chemical Society. The work was done in collaboration with the K. J. Patel lab at the University of Cambridge.
Wed Mar 22 2017
Shixian and Shang's paper was highlighted in the April issue of Nature Chemical Biology.
Wed Mar 22 2017
Chris' commentary appeared in Accounts of Chemical Research.
Mon Mar 20 2017
Shixian and Shang's paper was highlighted in a ACS Chemical Biology spotlight.
Mon Feb 27 2017
Shixian and Shang's paper was featured in a In the Pipeline story.
Fri Feb 10 2017
Shixian and Shang's paper appeared in Science. The work was done in collaboration with the Toste lab at UC Berkeley. It was featured in a Chemical & Engineering News story, a Berkeley Lab article, and a Phys. Org story.
Fri Jan 13 2017
Marie and Ho Yu's paper was featured in a Chemical & Engineering News story.
Fri Dec 16 2016
Cheri and Sumin's review appeared in Analytical Chemistry.
Fri Dec 2 2016
Marie and Ho Yu's paper appeared in Proceedings of the National Academy of Sciences of the United States of America. The work was done in collaboration with the A. Stahl lab at UC Berkeley.
Tues Nov 15 2016
Lakshmi and Joey's paper was featured in a NIGMS Biomedical Beat story.
Fri Oct 21 2016
Allegra's paper "An Endoperoxide Reactivity-Based FRET Probe for Ratiometric Fluorescence Imaging of Labile Iron Pools in Living Cells" appeared in the Journal of the American Chemical Society.
Tues Aug 9 2016
Lakshmi and Joey's paper was featured in a UC Science Today segment and a a PictureFit YouTube video.
Mon Aug 8 2016
Today, we're rolling out the new version of the Chang Lab website! Take a look around!
Tues July 26 2016
Karla and Safa's review "Thioether Coordination Chemistry for Molecular Imaging of Copper in Biological Systems" appeared in the Israel Journal of Chemistry.
Wed July 13 2016
Our collaborative paper "A reactivity-based probe of the intracellular labile ferrous iron pool" appeared in Nature Chemical Biology.
Mon June 27 2016
Lakshmi and Joey's paper was featured in a PictureFit YouTube video.
Mon June 20 2016
Zhi's collaborative paper "A Molecular Surface Functionalization Approach to Tuning Nanoparticle Electrocatalysts for Carbon Dioxide Reduction" appeared in the Journal of the American Chemical Society. The paper was a result of a collaboration with the Yang and Reimer groups.
Mon June 13 2016
Sumin's collaborative paper "Copper Capture in a Thioether-Functionalized Porous Polymer Applied to the Detection of Wilson's Disease" appeared in the Journal of the American Chemical Society. The paper was a result of a collaboration with the Long and Reimer groups.
Tues June 7 2016
Lakshmi and Joey's paper "Copper regulates cyclic-AMP-dependent lipolysis" appeared in Nature Chemical Biology. The paper was featured in an LBNL News Story, a UC Berkeley News Story, a Daily Mail News Story, a Genetic Engineering and Biotechnology News Story, a Dr Oz Reviews Story, a Men's Fitness Story, a Deccan Herald News Story, a Fitness First Mag Story, an Indo Asian News Service Story, a Health Canal News Story, a First Post News Story, a Business Standard News Story, a Health Site News Story, a Hindustan Times News Story, a Can-India News Story, a Natural Science News Story, a Times of India News Story, a Money Control News Story, an American Council on Science and Health News Story, a China Topix News Story, a MSN News Story, a Press Liberal News Story, a Headlines News Story, a Sentinel News Story, a Brief Report News Story, an Engine News Story, a 3 Novices News Story, an HT Syndication News Story, and a New York Indian News Story.
Mon May 30 2016
Wei's collaborative paper "A reactivity-based [18F]FDG probe for in vivo formaldehyde imaging using positron emission tomography" appeared in Chemical Science. The paper was a result of a collaboration with the D. Wilson laboratory at UCSF.
Fri 13 May 2016
Congratulations to Joey on accepting a faculty position at Pennsylvania State University! Check out his new faculty website!
Fri 13 May 2016
Congratulations to Ryan on accepting a faculty position at Ursinus College!
Tues 23 Feb 2016
Check out Song's new faculty website!
Sat 13 Feb 2016
Congratulations to Jean-Marc on accepting a position as an Assistant Adjunct Professor at the Institute for Neurodegenerative Diseases, UCSF!
Mon 25 Jan 2016
Congratulations to Song on accepting a faculty position at Cornell University!
Mon Nov 2 2015
Song's collaborative paper "Metal–Organic Frameworks for Electrocatalytic Reduction of Carbon Dioxide" appeared in the Journal of the American Chemical Society. The paper was a result of a collaboration with the O. Yaghi and P. Yang labs.
Fri Oct 2 2015
Chris' commentary "Searching for Harmony in Transition-Metal Signaling" appeared in Nature Chemical Biology.
Fri Oct 2 2015
Allegra's review "Recognition- and Reactivity-Based Fluorescent Probes for Studying Transition Metal Signaling in Living Systems" appeared in Accounts of Chemical Research.
Fri Sept 11 2015
Eva's collaborative paper "Hybrid bioinorganic approach to solar-to-chemical conversion" was featured in an IFL Science! Story. The paper was a result of a collaboration with the M. Chang and P. Yang labs.
Fri 11 Sept 2015
Congratulations to Annie Chantarojsiri for finishing her PhD, and best of luck in your postdoc at UC Irvine!
Mon 7 Sept 2015
Thom's paper "An Aza-Cope Reactivity-Based Fluorescent Probe for Imaging Formaldehyde in Living Cells" appeared in the Journal of the American Chemical Society. The paper was profiled in a Chemical & Engineering News Story.
Sun 30 Aug 2015
Song's collaborative paper "Covalent organic frameworks comprising cobalt porphyrins for catalytic CO2 reduction in water" appeared in Science. The paper is a result of a collaboration with the P. Yang and O. Yaghi labs, and was profiled in an LBNL News Story as well as a Science News Story.
Wed 26 Aug 2015
Eva's collaborative paper "Hybrid bioinorganic approach to solar-to-chemical conversion" appeared in Proceedings of the National Academy of Sciences of the United States of America. The paper is a result of a collaboration with the M. Chang and P. Yang labs, and was profiled in an LBNL News Story, a ScienceDaily News Story, a Demanjo News Story, a Science Newsline News Story, a Tech News Coverage News Story, an Adaptive Scientist News Story, and a Guldar News Story. It was also featured in the DOE's Science Headlines.
Fri 7 July 2015
Annie's collaborative review "Metal-Polypyridyl Catalysts for Electro- and Photochemical Reduction of Water to Hydrogen" appeared in Accounts of Chemical Research. The review was written in collaboration with the J. Long lab.
Mon 22 June 2015
Jonah and Eva's collaborative paper, "Bioinspired design of redox-active ligands for multielectron catalysis: effects of positioning pyrazine reservoirs on cobalt for electro- and photocatalytic generation of hydrogen from water," appeared in Chemical Science. The paper is a result of a collaboration with the M. Head-Gordon, J. Long, and F. Castellano labs.
Sun 7 June 2015
Annie's paper "Water-Soluble Iron(IV)-Oxo Complexes Supported by Pentapyridine Ligands: Axial Ligand Effects on Hydrogen Atom and Oxygen Atom Transfer Reactivity" appeared in Inorganic Chemistry.
Fri 5 June 2015
Thom and Carl's review "Chemical Approaches to Discovery and Study of Sources and Targets of Hydrogen Peroxide Redox Signaling Through NADPH Oxidase Proteins" appeared in the Annual Review of Biochemistry. The review was written in collaboration with the K. Carroll lab.
Tues 21 April 2015
Eva's collaborative paper was profiled in a Statesman article. The paper is a result of a collaboration with the P. Yang and M. Chang labs.
Mon 20 April 2015
Eva's collaborative paper was profiled in a Huffington Post article. The paper is a result of a collaboration with the P. Yang and M. Chang labs.
Fri 17 April 2015
Eva's collaborative paper, "Nanowire-Bacteria Hybrids for Unassisted Solar Carbon Dioxide Fixation to Value-Added Chemicals," appeared in Nano Lett. and was profiled in an LBNL News Story, a Tech Times News Story, a Science Times News Story, and a News Everyday News Story. It was also featured in the DOE's Science Headlines. The paper is a result of a collaboration with the P. Yang and M. Chang labs.
Wed 4 March 2015
Congratulations to Chang lab alumnus Sara Thoi on accepting a faculty position at Johns Hopkins University!
Tues 24 Feb 2015
Joey, Allegra, and Karla's review, "Synthetic fluorescent probes for studying copper in biological systems," appeared in Chemical Society Reviews.
Tues 24 Feb 2015
Vivian's review, "Chemical probes for molecular imaging and detection of hydrogen sulfide and reactive sulfur species in biological systems," appeared in Chemical Society Reviews.
Sun 30 Nov 2014
Sheel and Jeff's PNAS paper was profiled in an LBNL News Story, a C&E News Story, and a R&D Magazine News Story.
Fri 7 Nov 2014
Sheel and Jeff's paper, "Copper is an endogenous modulator of neural circuit spontaneous activity," appeared in PNAS.
Fri 17 Oct 2014
Brian's paper, "A Boronate-Caged [18F]FLT Probe for Hydrogen Peroxide Detection Using Positron Emission Tomography," appeared in JACS.
Mon 19 Aug 2014
The Chang Lab welcomes the new first-year students to the department! Come visit us at the Chembio poster session today (noon-2pm, B1 Stanley) or in our labs (401, 535, 610 Latimer). Open house is Monday, 8/25 from 1-4 PM in 532 Latimer.
Mon 19 Aug 2014
Publication of Amanda's latest paper, "A Well-Defined Terminal Vanadium(III) Oxo Complex," in Inorganic Chemistry marks the lab's 100th publication (125 overall)! The paper is a result of a collaboration with the Long and Neese labs.
Mon 19 Aug 2014
Our metals in neurobiology work presented at ACS was highlighted in an LBNL story, which was reposted by R&D magazine.
Mon 4 Aug 2014
Congratulations to Carl Onak and Vivian Lin for finishing their PhDs!
Thurs 29 May 2014
Congratulations to Brian on accepting a faculty position at the University of Denver!
Wed 14 May 2014
The lab welcomes Corey into the Chang lab family!
Mon 21 April 2014
Congratulations to Chang lab alumnus Bryan Dickinson on accepting a faculty position at the University of Chicago!
Tue 8 Apr 2014
Congratulations to Jeff on accepting a faculty position at the University of Illinois at Urbana-Champaign!
Tue 8 Apr 2014
Congratulations to Jonah on accepting a faculty position at the University of Mississippi!
Tue 8 Apr 2014
Congratulations to Michael on accepting a faculty position at the Texas A&M!
Wed 12 Feb 2014
Take a look at the redesigned research section of the website and learn about our four research areas: Chemical Biology, Bioinorganic Chemistry, Organic Chemistry, and Inorganic Chemistry!
Tue 19 Nov 2013
Yujie's paper, "Electrodeposited Cobalt-Sulfide Catalyst for Electrochemical and Photoelectrochemical Hydrogen Generation from Water," appeared in JACS.
Mon 11 Nov 2013
Congratulations to Harini on starting your new job at Genentech!
Tue 24 Sep 2013
Ho Yu, Jeff, and Annie's paper, "Molecular Imaging of Labile Iron(II) Pools in Living Cells with a Turn-On Fluorescent Probe," appeared in JACS.
Mon 16 Sep 2013
Sara's paper, "Visible-Light Photoredox Catalysis: Selective Reduction of Carbon Dioxide to Carbon Monoxide by a Nickel N-Heterocyclic Carbene-Isoquinoline Complex," appeared in JACS.
Mon 16 Sep 2013
Congratulations to Ho Yu on starting your faculty position at the University of Hong Kong!
Mon 16 Sep 2013
Congratulations to Yujie on starting your faculty position at Utah State University!
Mon 16 Sep 2013
Congratulations to Sheel for finishing your PhD and on starting your postdoc in the Arnold Group at Caltech!
Mon 16 Sep 2013
Congratulations to Sara for finishing your PhD and on starting your postdoc in the Haile Group at Caltech!
Tue 13 Aug 2013
The group's latest paper, "Catalytic Proton Reduction with Transition Metal Complexes of the Redox-active Ligand bpy2PYMe," appeared in Chemical Science.
Wed 3 Jul 2013
Vivian and Alex's paper on cell-trappable hydrogen sulfide probes was highlighted in a Faculty of 1000 Recommendation.
Tue 25 Jun 2013
Vivian and Bryan's chapter, "Boronate-Based Fluorescent Probes: Imaging Hydrogen Peroxide in Living Systems," appeared in the latest volume of Methods in Enzymology.
Mon 17 Jun 2013
Vivian and Alex's paper on cell-trappable hydrogen sulfide probes was highlighted in a Chemical Research in Toxicology Spotlight.
Fri 7 Jun 2013
Bryan and Vivian's paper, "Preparation and use of MitoPY1 for imaging hydrogen peroxide in mitochondria of live cells," appeared in Nature Protocols.
Tue 28 May 2013
The lab's work on copper imaging was profiled in an LBNL News Highlight.
Tue 23 Apr 2013
Vivian and Alex's paper was highlighted in C&E News.
Thu 18 Apr 2013
Vivian and Alex's paper, "Cell-trappable Fluorescent Probes for Endogenous Hydrogen Sulfide Signaling and Imaging H2O2-Dependent H2S Production," appeared in PNAS.
Fri 22 Feb 2013
Amanda, Nick, and Julian's paper, "A Mechanistic Study of Proton Reduction Catalyzed by a Pentapyridine Cobalt Complex: Evidence for Involvement of an Anation-Based Pathway," appeared in Chemical Science.
Sun 27 Jan 2013
Genevieve's paper, "Strategy for Dual-Analyte Luciferin Imaging: In Vivo Bioluminescence Detection of Hydrogen Peroxide and Caspase Activity in a Murine Model of Acute Inflammation," appeared in JACS.
Mon 21 Jan 2013
Congratulations to Mike on graduating, and best of luck at Gmab!
Mon 21 Jan 2013
Best of luck to Amanda at Los Alamos National Lab!
Mon 21 Jan 2013
Congratulations to Genevieve on graduating, and best of luck in your postdoc at Harvard/MGH!
Thu 13 Dec 2012
Jeff and Sheel's review, "Reaction-based small-molecule fluorescent probes for chemoselective bioimaging," appeared in Nature Chemistry.
Mon 22 Oct 2012
Sara and Yujie's review, "Complexes of earth-abundant metals for catalytic electrochemical hydrogen generation under aqueous conditions," appeared in Chemical Society Reviews.
Mon 22 Oct 2012
Vivian's review on fluorescent probes for H2S appeared in Current Opinion in Chemical Biology.
Mon 24 Sep 2012
Yujie's paper, "Photocatalytic generation of hydrogen from water using a cobalt pentapyridine complex in combination with molecular and semiconductor nanowire photosensitizers," appeared in Chemical Science.
Mon 24 Sep 2012
Brian and Alex's paper on a reaction-based fluorescent probe for carbon monoxide was highlighted in C&E News.
Sun 16 Sep 2012
Brian and Alex's paper on a reaction-based fluorescent probe for carbon monoxide appeared in JACS.
Sun 26 Aug 2012
Congratulations to Chang lab alumnus Bryan Dickinson for winning the Nobel Laureate Signature Award from the ACS for best thesis!
Sun 26 Aug 2012
Hill, Mike, and Nick's paper on vanadium organoazide complexes and their conversion to terminal vanadium imides appeared in Inorganic Chemistry.
Tue 31 Jul 2012
Congratulations to Julian on earning your PhD! Best of luck at Kinestral Technologies.
Tue 31 Jul 2012
Congratulations to Alex on starting your lab at SMU Chemistry! Best of luck in your independent career.
Tue 24 Apr 2012
Ho Yu and Liz's paper, "A selective reaction-based fluorescent probe for detecting cobalt in living cells," appeared in ChemComm.
Mon 23 Apr 2012
Sara and Hema's paper, "Electrochemical generation of hydrogen from acetic acid using a molecular molybdenum-oxo catalyst," appeared in Energy and Environmental Science.
Wed 18 Apr 2012
Emily and Liz's paper, "A cell-permeable gadolinium contrast agent for magnetic resonance imaging of copper in a Menkes disease model," appeared in Chemical Science today.
Thu 8 Mar 2012
Sara and Hema's paper, "Computational and Experimental Study of the Mechanism of Hydrogen Generation from Water by a Molecular Molybdenum-Oxo Electrocatalyst," appeared in JACS today.
Fri 10 Feb 2012
Hema and Yujie's paper, "A Molecular MoS2 Edge Site Mimic for Catalytic Hydrogen Generation," appeared in Science and was highlighted in a UC Berkeley press release, an LBNL press release, a Daily Cal article, and a C&E News article.
Wed 1 Feb 2012
Genevieve and Tasuku's paper on a fluorescent near-IR probe for imaging copper in living mice appeared today in PNAS.
Wed 4 Jan 2012
Julian and Hill's paper, "A High-Spin Iron(IV)-Oxo Complex Supported by a Trigonal Nonheme Pyrrolide Platform," appeared today in JACS.
Fri 28 Oct 2011
Alex and Liz's paper on fluorescent reaction-based H2S probes was featured in C&E News.
Tue 6 Sep 2011
Bryan's paper on a nuclear H2O2 probe and its use in monitoring sirtuin-mediated oxidative stress appeared in Chemistry & Biology.
Thu 11 Aug 2011
Alex and Genevieve's review appeared today in Accounts of Chemical Research.
Wed 3 Aug 2011
May's paper on a ratiometric two-photon hydrogen peroxide probe appeared in ChemComm.
Tue 19 Jul 2011
Bryan's review on the chemistry and biology of reactive oxygen species in cellular signaling and stress responses appeared today in Nature Chemical Biology.
Mon 11 Jul 2011
Liz is the recipient of the 2011 Dalton Young Researchers Award. Congratulations!
Mon 20 Jun 2011
Alex and Liz's paper on a selective H2S probe appeared in JACS.
Wed 25 May 2011
Yujie, Julian, and Nick's paper on molecular cobalt pentapyridine catalysts for generating hydrogen from water appeared today in JACS.
Mon 16 May 2011
Sheel's paper on a new mitochondrial copper probe and its application to imaging mitochondrial copper pools in fibroblasts with mutant SCO1 and SCO2 enzymes appeared today in JACS.
Tue 10 May 2011
Sara's paper on nickel N-heterocyclic carbene-pyridine complexes that exhibit selectivity for electrocatalytic reduction of carbon dioxide over water appeared today in ChemComm.
Tue 29 Mar 2011
Sheel, Dylan, Christine, and Evan's paper on copper redistributions in neuronal cells appeared yesterday in PNAS.
Mon 21 Mar 2011
May and Aaron's paper on a dendrimer-based fluorescent sensor for imaging H2O2 and pH gradients in cells appeared last week in Chemical Science.
Wed 9 Mar 2011
Added today: a new group photo and pictures of Dylan's going away party at Albany Bowl.
Sat 5 Mar 2011
Alex's paper on a hyperpolarized 13C MRI probe for hydrogen peroxide appeared this week in JACS.
Thu 10 Feb 2011
Genevieve's recent PNAS paper on hydrogen peroxide imaging in mice was featured on the Lawrence Berkeley Lab website.
Wed 2 Feb 2011
Nick, Mike, and Hill's paper on a vanadium complex that binds nitrous oxide appeared today in JACS.
Tue 11 Jan 2011
Bryan's paper on H2O2 imaging in neural stem cells and Genevieve's paper on H2O2 imaging in live mice were highlighted in C&E News.
Fri 31 Dec 2010
Added today: photos from Anne's going away party at Jupiter.
Sun 26 Dec 2010
Bryan's paper on redox signaling in neural stem cells appeared today in Nature Chemical Biology.
Wed 22 Dec 2010
Genevieve's recent PNAS paper on hydrogen peroxide imaging in mice was given a "must read" rating by the Faculty of 1000.
Wed 8 Dec 2010
Hill's paper on slow magnetic relaxation in trigonal pyramidal iron(II) pyrrolide complexes appeared today in JACS.
Mon 29 Nov 2010
Genevieve's paper on hydrogen peroxide imaging in mice appeared today in PNAS.
Mon 22 Nov 2010
Evan, Carl, and Liz's paper describing a photocaged hydrogen peroxide generator appeared last week in JACS.
Fri 5 Nov 2010
Added today: photos of Bryan's going away party at the Trappist.
Mon 1 Nov 2010
Congratulations to Bryan on earning your Ph.D. Best of luck at Harvard!
Thu 21 Oct 2010
Evan and Bryan's recent PNAS paper on the role of aquaporins in cellular uptake of hydrogen peroxide was highlighted in ACS Chemical Biology and was given a "must read" rating by the Faculty of 1000.
Tue 31 Aug 2010
Congratulations to Hill on earning your Ph.D. and Danielle on earning your M.S. Best of luck to both of you at Caltech!
Tue 31 Aug 2010
Fall group meetings start Sep 1. First-years, join us for pizza on Wednesdays at 7:00pm in 775B Tan.
Tue 24 Aug 2010
Added today: Techniques that we use in our research.
Thu 19 Aug 2010
Added today: Bryan's photo album.
Thu 19 Aug 2010
Added today: Photos of group dinner and Pink Saturday and Hawaii retreat, 2009.
Wed 18 Aug 2010
Added today: Photos of the group trip to the Giants game on HHMI Staff Appreciation Day.
Tue 17 Aug 2010
First-year students: join us for our group meeting tonight in 775B Tan at 7:00pm.
Tue 17 Aug 2010
The Chang Lab welcomes the new first-year students to the department! Come visit us at the Chembio poster session today (noon-2pm, 775 Tan) or in our labs (401, 535, 610 Latimer).