Research Interests
Chemical Biology and Inorganic Chemistry
Our laboratory studies the chemistry of biology and energy. We advance new concepts in imaging, proteomics, drug discovery, and catalysis by drawing from core disciplines of inorganic, organic, and biological chemistry. For example, we have developed activity-based sensing as a general platform to identify transition metals, reactive oxygen species, and one-carbon units as new classes of single-atom signals for allosteric regulation of protein function. These chemical tools also reveal unique metal and redox disease vulnerabilities as targets for innovative drug discovery efforts to treat neurodegeneration, cancer, and metabolic disorders. Our work in artificial photosynthesis addresses global challenges in climate change. We use design concepts from biology to develop molecular electrocatalysts for carbon dioxide capture and conversion and nitrogen/phosphorus cycling. Representative project areas are summarized below.
News

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Our recent study on the regulation of S-adenosylmethionine biosynthesis and one-carbon metabolism by formaldehyde was published in Science! Congrats to Vanha and Kevin. Read it here!
Tue July 25, 2023
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We are excited to share our newly published paper on electrochemical nitrate reduction catalyzed by cobalt porphyrin organic cages for ammonia electrosynthesis in water. Read it here. Congrats to Lun, Mina, Peter and Paty!
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Tue June 6, 2023
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Farewell to Eva! She has completed her postdoc with us and will be starting her career as an assistant professor at the University of North Carolina, Charlotte. We wish you all the best!
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Mon June 5, 2023
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Congratulations to Mina, a postdoc in the inorganic subgroup, who will be starting his industry career at Dow in Michigan next month. Good luck!
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Tue May 30, 2023
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This month we bid farewell to our postdoc Marco. He is starting his independent career at the University of Delaware. Congratulations! Check out Marco's lab here.
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Wed May 17, 2023
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Congratulations to Paty for completing her PhD and starting her new job at the California Energy Commission in Sacramento. We wish her all the best!
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Wed March 29, 2023
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Congrats to Luke for receiving the NSF GRFP fellowship!
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Mon March 13, 2023
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We are excited to share that our second-year students Aila, Luke and Jayde have all passed their qualifying exams this year, officially making them PhD candidates.
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Wed Feb 15, 2023
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Congrats to Vanha on her review on metalloallostery and transition metal signaling. Read it here!
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Mon Jan 2, 2023
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Congratulations to Lun, Paty, and Mina on their study on synergistic porosity and charge effects for photochemical CO2 reduction appearing in Angewandte Chemie!
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Fri Dec 9, 2022
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Congrats to Angel, Audrey, and collaborators in the Toste group and Novartis on their paper using ReACT to discover and drug new methionine redox sites that crosstalk with phosphorylation in the high-value cancer drug target CDK4 appearing in JACS!
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Thur Oct 20, 2022
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Congratulations to Aidan and former post-doc Carson, as well as our collaborators Brady, DeNicola and Su, on their newly published PNAS paper on oxidation state-specific copper sensors. Read it here!
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Tues Sept 13, 2022
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Welcome to our lab Satoshi and Gen!
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Tues May 17, 2022
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Happy graduation to Jeff and Audrey! Best wishes in your next endeavors.
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Sat May 14, 2022
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Congrats to Audrey and Logan for winning best poster prizes at Chemical Biology in the Bay Area Day! And a great talk by Vanha.
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Mon May 9, 2022
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Welcome Jayde to our lab after first-year rotations. Best wishes with your PhD work!
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Thurs Apr 28, 2022
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Eva presented at the Chemical Biology and Physiology conference at OHSU. Great work!
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Wed Mar 23, 2022
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Congrats to Audrey for an awesome talk and to Vanha for the best poster prize at the MCB departmental BBS retreat.
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Wed Mar 2, 2022
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Congratulations to Logan and Abby for passing their qualifying exams!
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Mon Nov 29, 2021
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We welcome chembio student Soren to our lab. Happy rotation!
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Fri Nov 12, 2021
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Check out Eva's recently published Nature Reviews on copper and cancer. Congrats!
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Mon Oct 18, 2021
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We're excited to welcome inorganic graduate students Aila and Luke!
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Wed Sept 15, 2021
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We welcome rotation student Jayde to the lab!
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Wed July 28, 2021
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Congrats to Shang for his paper on his microtubule-localizing H2O2 probe!
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Sat May 15, 2021
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Congratulations to our undergraduate seniors Alan, Kaede, and Rachel on your graduation! Looking forward to seeing the great things you do.
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Mon May 10, 2021
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Welcome to first-year ChemBio grad student Abby to the lab! We're excited to have you with us.
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Tues Feb 23, 2021
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Congratulations to Hide and Marco on their new PNAS paper on imaging transcellular peroxide signaling.
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Tues Dec 15, 2020
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Zeming's paper on his potassium sensor RPS-1 has been published in Chemical Science.
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Fri Nov 20, 2020
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Check out Jeff's recently published paper on metal–ligand cooperativity for electrocatalysis!
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Mon Nov 9, 2020
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We welcome first-year grad student Logan to our lab!
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Mon Sept 29, 2020
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Check out Joel and Steven's paper that was recently published in PNAS, featuring a mechanistic study comparing two RNA demethylation pathways.
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Thurs Sept 10, 2020
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Congrats to our former PhD student Eva on accepting a faculty position at UBC! Check out Eva's
lab website.
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Tues Sept 8, 2020
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Congrats to our former postdoc Clive on starting a faculty position at University of Hong Kong! Check out Clive's
staff page.
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Tues Sept 1, 2020
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Check out our new CO activity-based sensing paper that was published in JACS.
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Fri Aug 28, 2020
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Congrats to Kevin for finishing his PhD, and best of luck in your postdoc with the Bertozzi group at Stanford!
| Congrats to Peter for finishing his PhD, and best of luck in your postdoc with the Mirkin group at Northwestern!
Thurs Aug 20, 2020
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Sumin and Clive's paper on activity-based sensing using a copper-directed acyl imidazole strategy appeared in JACS. This work was done in collaboration with the Miller, Saijo, and Hamachi labs.
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Wed May 6, 2020
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Congratulations to Jun on accepting a faculty position at North Carolina State. Check out Jun's new group website.
| Congratulations to Diana on accepting a faculty position at Virginia Tech! Take a look at Diana's intro video for Virginia Tech, and check out Diana's faculty page.
Tues May 5, 2020
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We're excited to welcome Angel to our lab! Congrats on completing your lab rotations and officially joining us!
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Thur Mar 12, 2020
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For prospective students with canceled visit weekends, please feel free to reach out to anyone in the lab if you would like more information. Emails are listed under the Current Members section. Check out our new virtual lab tour to see the lab!
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Tues Jan 7, 2020
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Peter's paper appeared in Angew. Chemie. The work was done in collaboration with the Kim lab. |
Tues Jan 7, 2020
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Jun and Lakshmi's paper appeared in ACS Central Science. The work was done in collaboration with the Miller and Toste labs. |
Thur Sept 5, 2019
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Jun and Kevin's review appeared in Acc. Chem. Res. |
Thur Sept 5, 2019
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Congratulations to Shang for finishing his PhD, and best of luck in your postdoc with the Sletten Group at UCLA! |
Thur Aug 29, 2019
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Clive and Sumin's paper appeared in PNAS. The work was done in collaboration with the Brady lab. |
Mon Aug 5, 2019
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Alec and Shang's paper appeared in JACS. The work was a collaboration with the Sigman and Toste labs. |
Tue July 2 2019
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Congratulations to Tim on accepting a faculty position at UC Riverside! Check out his lab website. |
Mon June 17 2019
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Tim and Kevin's review appeared in Curr. Opin. Biotechnology |
Fri June 7 2019
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Diana and Shang's review appeared in Inorg. Chem. |
Thur June 6 2019
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Sumin's paper appeared in Chem. Sci. The work was done in collaboration with the Long lab. |
Wed June 5 2019
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Congratulations to Ming on accepting a faculty position at Fudan University! |
Thur May 16 2019
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Tim and Marie's paper appeared in Cancers.The work was done in collaboration with the Toietta lab. |
Wed April 24 2019
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Shang's paper appeared in JACS. |
Tues February 12 2019
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The lab welcomes visitng scholar Tri and two chemical biology rotation students: Eli and Sarah!
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Tues February 12 2019
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Congratulations to Byungsun on accepting a faculty position at the Korean Institute of Science and Technology! |
Thurs November 15 2018
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The lab welcomes new graduate student Paty and three chemical biology rotation students: Naiya, Paul, and Rei Chi!
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Tue October 23 2018
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Tim's paper was highlighted in JACS Spotlights.
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Tue October 16 2018
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Tim's paper appeared in JACS. The work was done in collaboration with the Stahl lab.
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Tue October 16 2018
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Marie's collaboration with the Skaar lab appeared in Infection and Immunity.
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Tue August 14 2018
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Congratulations to Zhi on accepting a faculty position at the Institute of Coal Chemistry, Chinese Academy of Sciences! |
Tue August 14 2018
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Congratulations to Zeming for finishing his PhD, and best of luck in your postdoc with the Cohen Group at LBNL!
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Tue August 14 2018
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Congratulations to Sumin for finishing her PhD, and best of luck in your postdoc with the Bogyo Group at Stanford!
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Fri July 27 2018
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Tong's paper was featured in a HWNI article.
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Mon July 9 2018
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Peter's paper appeared in Angew. Chem. Int. Ed. The work was done in collaboration with the Kim lab.
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Tues July 3 2018
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Eva's paper appeared in Organometallics.
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Wed June 27 2018
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Congratulations to Allegra for finishing her PhD, and best of luck in your postdoc with the Dorrestein Group at UCSD!
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Thurs June 14 2018
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Lakshmi's viewpoint appeared in Biochemistry. |
Tues June 12 2018
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Tong's paper was featured in a C&E News article.
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Wed June 6 2018
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Tong's paper appeared in Nat. Chem. Biol. The work was done in collaboration with the Isacoff lab.
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Thur May 3 2018
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Clive's paper appeared in J. Am. Chem. Soc. The work was done in collaboration with the Saijo lab.
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Mon April 16 2018
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Kevin and Tim's paper appeared in Angew. Chemie. Int. Ed. The work was done in collaboration with the Shabat lab.
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Thurs Mar 8 2018
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Cheri's paper appeared in Metallomics The work was done in collaboration with the Weber and Pett-Ridge labs.
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Wed Mar 5 2018
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Zhi and Jeff's paper appeared in Angew. Chemie. Int. Ed. The work was done in collaboration with the Coperet and Wen labs.
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Wed Feb 21 2018
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Eva and Jeff's paper appeared in Chem. Sci.
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Wed Jan 17 2018
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Allegra and Audrey's review appeared in Curr. Opin. Chem. Biol |
Tue Jan 2 2018
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Allegra's collaboration appeared in eLIFE. The work was done in collaboration with the Renslo, Monje, and Wang labs.
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Fri Dec 1 2017
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Congratulations to Eva for finishing her PhD, and best of luck in your postdoc with the Mayer Group at Yale!
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Fri Dec 1 2017
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Congratulations to Shixian on accepting a faculty position at Zhejiang University!
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Tue Nov 14 2017
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Allegra and Marie's paper appeared in PNAS. The work was done in collaboration with the Skaar lab at Vanderbilt University and the Stahl lab at UC Berkeley.
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Wed Oct 13 2017
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Congratulations to Cheri for finishing her PhD, and best of luck in your postdoc at the Broad Institute in the Blainey Lab! |
Thurs Sep 13 2017
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Ming, Zhi, and Wei's paper appeared in ACS Central Science. |
Thurs Aug 17 2017
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Thom's collaboration with the KJ Patel Lab appeared in Nature.
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Mon Aug 14 2017
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The lab welcomes three new postdoctoral researchers: Byungsun, Diana, and Joel!
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Wed Jul 19 2017
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The website has been updated to be mobile friendly.
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Tues Jun 28 2017
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Congratulations to Marie for accepting a faculty position at UC Davis!
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Tues Jun 27 2017
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Congratulations to Wei for accepting a faculty position at Miami University of Ohio!
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Fri Jun 2 2017
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The lab welcomes Wendy, a visiting Amgen scholar for the summer from Cornell!
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Mon May 29 2017
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Kevin and Thom's review
appeared in Current Opinion in Chemical Biology.
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Mon May 29 2017
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Congratulations to Thom for finishing his PhD, and best of luck in your postdoc at Princeton in the Macmillan Lab!
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Thu April 13 2017
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Congratulations to Chris, who has been elected
into the American Academy of Arts and Sciences.
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Fri April 7 2017
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Thom's paper
appeared in Chemical Science. The work was done in collaboration with the K. J. Patel lab at the
University of Cambridge.
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Tues April 4 2017
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Kevin, Ryan, and Thom's paper
appeared in the Journal of the American Chemical Society. The work was done in collaboration with the K. J. Patel lab at the
University of Cambridge.
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Wed Mar 22 2017
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Shixian and Shang's paper
was highlighted in the April issue of Nature Chemical Biology.
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Wed Mar 22 2017
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Chris' commentary
appeared in Accounts of Chemical Research.
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Mon Mar 20 2017
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Shixian and Shang's paper
was highlighted in a ACS Chemical Biology spotlight.
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Mon Feb 27 2017
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Shixian and Shang's paper
was featured in a In the Pipeline story.
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Fri Feb 10 2017
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Shixian and Shang's paper
appeared in Science. The work was done in collaboration with the Toste lab at UC Berkeley. It was featured in a Chemical & Engineering News story,
a Berkeley Lab article, and a Phys. Org story.
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Fri Jan 13 2017
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Marie and Ho Yu's paper
was featured in a Chemical & Engineering News story.
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Fri Dec 16 2016
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Cheri and Sumin's review
appeared in Analytical Chemistry.
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Fri Dec 2 2016
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Marie and Ho Yu's paper
appeared in Proceedings of the National Academy of Sciences of the United States of America.
The work was done in collaboration with the A. Stahl lab at UC Berkeley.
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Tues Nov 15 2016
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Lakshmi and Joey's paper
was featured in a NIGMS Biomedical Beat story.
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Fri Oct 21 2016
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Allegra's paper
"An Endoperoxide Reactivity-Based FRET Probe for Ratiometric Fluorescence Imaging of Labile Iron Pools in Living Cells"
appeared in the Journal of the American Chemical Society.
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Tues Aug 9 2016
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Lakshmi and Joey's paper
was featured in a UC Science Today segment and a
a PictureFit YouTube video.
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Mon Aug 8 2016
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Today, we're rolling out the new version of the Chang Lab website! Take a look around!
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Tues July 26 2016
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Karla and Safa's review
"Thioether Coordination Chemistry for Molecular Imaging of Copper in Biological Systems" appeared in the Israel Journal of Chemistry.
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Wed July 13 2016
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Our collaborative paper
"A reactivity-based probe of the intracellular labile ferrous iron pool" appeared in Nature Chemical Biology.
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Mon June 27 2016
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Lakshmi and Joey's paper
was featured in a PictureFit YouTube video.
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Mon June 20 2016
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Zhi's collaborative paper
"A Molecular Surface Functionalization Approach to Tuning Nanoparticle Electrocatalysts for Carbon Dioxide Reduction"
appeared in the Journal of the American Chemical Society.
The paper was a result of a collaboration with the Yang and Reimer groups.
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Mon June 13 2016
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Sumin's collaborative paper
"Copper Capture in a Thioether-Functionalized Porous Polymer Applied to the Detection of Wilson's Disease"
appeared in the Journal of the American Chemical Society.
The paper was a result of a collaboration with the Long and Reimer groups.
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Tues June 7 2016
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Lakshmi and Joey's paper
"Copper regulates cyclic-AMP-dependent lipolysis" appeared in Nature Chemical Biology. The paper was featured in an LBNL News Story,
a UC Berkeley News Story,
a Daily Mail News Story,
a Genetic Engineering and Biotechnology News Story,
a Dr Oz Reviews Story,
a Men's Fitness Story,
a Deccan Herald News Story,
a Fitness First Mag Story,
an Indo Asian News Service Story,
a Health Canal News Story,
a First Post News Story,
a Business Standard News Story,
a Health Site News Story,
a Hindustan Times News Story,
a Can-India News Story,
a Natural Science News Story,
a Times of India News Story,
a Money Control News Story,
an American Council on Science and Health News Story,
a China Topix News Story,
a MSN News Story,
a Press Liberal News Story,
a Headlines News Story,
a Sentinel News Story,
a Brief Report News Story,
an Engine News Story,
a 3 Novices News Story,
an HT Syndication News Story,
and a New York Indian News Story.
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Mon May 30 2016
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Wei's collaborative paper
"A reactivity-based [18F]FDG probe for in vivo formaldehyde imaging using positron emission tomography"
appeared in Chemical Science.
The paper was a result of a collaboration with the D. Wilson laboratory at UCSF.
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Fri 13 May 2016
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Congratulations to Joey on accepting a faculty position at Pennsylvania State University! Check out his new faculty website!
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Fri 13 May 2016
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Congratulations to Ryan on accepting a faculty position at Ursinus College!
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Tues 23 Feb 2016
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Check out Song's new faculty website!
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Sat 13 Feb 2016
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Congratulations to Jean-Marc on accepting a position as an Assistant Adjunct Professor
at the Institute for Neurodegenerative Diseases, UCSF!
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Mon 25 Jan 2016
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Congratulations to Song on accepting a faculty position at Cornell University!
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Mon Nov 2 2015
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Song's collaborative paper
"Metal–Organic Frameworks for Electrocatalytic Reduction of Carbon Dioxide"
appeared in the Journal of the American Chemical Society.
The paper was a result of a collaboration with the O. Yaghi and P. Yang labs.
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Fri Oct 2 2015
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Chris' commentary
"Searching for Harmony in Transition-Metal Signaling"
appeared in Nature Chemical Biology.
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Fri Oct 2 2015
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Allegra's review
"Recognition- and Reactivity-Based Fluorescent Probes for Studying Transition Metal Signaling in Living Systems"
appeared in Accounts of Chemical Research.
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Fri Sept 11 2015
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Eva's collaborative paper
"Hybrid bioinorganic approach to solar-to-chemical conversion" was featured in an IFL Science!
Story.
The paper was a result of a collaboration with the M. Chang and P. Yang labs.
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Fri 11 Sept 2015
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Congratulations to Annie Chantarojsiri for finishing her PhD, and best of luck in your postdoc at UC Irvine!
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Mon 7 Sept 2015
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Thom's paper
"An Aza-Cope Reactivity-Based Fluorescent Probe for Imaging Formaldehyde in Living Cells"
appeared in the Journal of the American Chemical Society. The paper was profiled
in a Chemical & Engineering News Story.
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Sun 30 Aug 2015
|
Song's collaborative paper
"Covalent organic frameworks comprising cobalt porphyrins for catalytic CO2 reduction in water"
appeared in Science. The paper is a result of a collaboration with the P. Yang and O. Yaghi labs,
and was profiled in an LBNL News Story
as well as a Science News Story.
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Wed 26 Aug 2015
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Eva's collaborative paper
"Hybrid bioinorganic approach to solar-to-chemical conversion"
appeared in Proceedings of the National Academy of Sciences of the United States of America. The paper is a result of a collaboration with the M. Chang and P. Yang labs,
and was profiled in an LBNL News Story,
a ScienceDaily News Story,
a Demanjo News Story,
a Science Newsline News Story,
a Tech News Coverage News Story,
an Adaptive Scientist News Story,
and a Guldar News Story.
It was also featured in the DOE's Science Headlines.
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Fri 7 July 2015
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Annie's collaborative review
"Metal-Polypyridyl Catalysts for Electro- and Photochemical Reduction of Water to Hydrogen"
appeared in Accounts of Chemical Research. The review was written in collaboration with the J. Long lab.
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Mon 22 June 2015
|
Jonah and Eva's collaborative paper,
"Bioinspired design of redox-active ligands for multielectron catalysis: effects of positioning pyrazine reservoirs on cobalt for electro- and photocatalytic generation of hydrogen from water,"
appeared in Chemical Science. The paper is a result of a collaboration with the M. Head-Gordon, J. Long, and F. Castellano labs.
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Sun 7 June 2015
|
Annie's paper
"Water-Soluble Iron(IV)-Oxo Complexes Supported by Pentapyridine Ligands: Axial Ligand Effects on Hydrogen Atom and Oxygen Atom Transfer Reactivity"
appeared in Inorganic Chemistry.
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Fri 5 June 2015
|
Thom and Carl's review
"Chemical Approaches to Discovery and Study of Sources and Targets of Hydrogen Peroxide Redox Signaling Through NADPH Oxidase Proteins"
appeared in the Annual Review of Biochemistry. The review was written in collaboration with the K. Carroll lab.
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Tues 21 April 2015
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Eva's collaborative paper
was profiled in a Statesman article.
The paper is a result of a collaboration with the P. Yang and M. Chang labs.
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Mon 20 April 2015
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Eva's collaborative paper
was profiled in a Huffington Post article.
The paper is a result of a collaboration with the P. Yang and M. Chang labs.
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Fri 17 April 2015
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Eva's collaborative paper,
"Nanowire-Bacteria Hybrids for Unassisted Solar Carbon Dioxide Fixation to Value-Added Chemicals,"
appeared in Nano Lett. and was profiled in an LBNL
News Story,
a Tech Times News Story,
a Science Times News Story,
and a News Everyday News Story.
It was also featured in the DOE's Science Headlines.
The paper is a result of a collaboration with the P. Yang and M. Chang labs.
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Wed 4 March 2015
|
Congratulations to Chang lab alumnus Sara Thoi on accepting a faculty position at Johns Hopkins University!
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Tues 24 Feb 2015
|
Joey, Allegra, and Karla's review,
"Synthetic fluorescent probes for studying copper in biological systems,"
appeared in Chemical Society Reviews.
|
Tues 24 Feb 2015
|
Vivian's review,
"Chemical probes for molecular imaging and detection of hydrogen sulfide and reactive sulfur species in biological systems,"
appeared in Chemical Society Reviews.
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Sun 30 Nov 2014
|
Sheel and Jeff's PNAS paper was profiled in an
LBNL News Story, a C&E News Story,
and a R&D Magazine News Story.
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Fri 7 Nov 2014
|
Sheel and Jeff's paper,
"Copper is an endogenous modulator of neural circuit spontaneous activity,"
appeared in PNAS.
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Fri 17 Oct 2014
|
Brian's paper,
"A Boronate-Caged [18F]FLT Probe for Hydrogen Peroxide Detection Using Positron Emission Tomography,"
appeared in JACS.
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Mon 19 Aug 2014
|
The Chang Lab welcomes the new first-year students to the department!
Come visit us at the Chembio
poster session today (noon-2pm, B1 Stanley) or in our labs (401, 535, 610 Latimer). Open house is Monday, 8/25 from 1-4 PM in 532 Latimer.
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Mon 19 Aug 2014
|
Publication of Amanda's latest paper, "A Well-Defined Terminal Vanadium(III) Oxo Complex," in Inorganic Chemistry marks the lab's 100th publication (125 overall)! The paper is a result of a collaboration with the Long and Neese labs.
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Mon 19 Aug 2014
|
Our metals in neurobiology work presented at ACS was highlighted in an LBNL story, which was reposted by R&D magazine.
|
Mon 4 Aug 2014
|
Congratulations to Carl Onak and Vivian Lin for finishing their PhDs!
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Thurs 29 May 2014
|
Congratulations to Brian on accepting a faculty position at the University of Denver!
|
Wed 14 May 2014
|
The lab welcomes Corey into the Chang lab family!
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Mon 21 April 2014
|
Congratulations to Chang lab alumnus Bryan Dickinson on accepting a faculty position at the University of Chicago!
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Tue 8 Apr 2014
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Congratulations to Jeff on accepting a faculty position at the University of Illinois at Urbana-Champaign!
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Tue 8 Apr 2014
|
Congratulations to Jonah on accepting a faculty position at the University of Mississippi!
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Tue 8 Apr 2014
|
Congratulations to Michael on accepting a faculty position at the Texas A&M!
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Wed 12 Feb 2014
|
Take a look at the redesigned research
section of the website and learn about our four research areas:
Chemical Biology,
Bioinorganic Chemistry,
Organic Chemistry,
and Inorganic Chemistry!
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Tue 19 Nov 2013
|
Yujie's paper,
"Electrodeposited Cobalt-Sulfide Catalyst for Electrochemical and Photoelectrochemical Hydrogen Generation from Water,"
appeared in JACS.
|
Mon 11 Nov 2013
|
Congratulations to Harini on starting your new job at Genentech!
|
Tue 24 Sep 2013
|
Ho Yu, Jeff, and Annie's paper,
"Molecular Imaging of Labile Iron(II) Pools in Living Cells with a Turn-On Fluorescent Probe,"
appeared in JACS.
|
Mon 16 Sep 2013
|
Sara's paper,
"Visible-Light Photoredox Catalysis: Selective Reduction of Carbon Dioxide to Carbon Monoxide by a Nickel N-Heterocyclic Carbene-Isoquinoline Complex,"
appeared in JACS.
|
Mon 16 Sep 2013
|
Congratulations to Ho Yu on starting your faculty position at the University of Hong Kong!
|
Mon 16 Sep 2013
|
Congratulations to Yujie on starting your faculty position at Utah State University!
|
Mon 16 Sep 2013
|
Congratulations to Sheel for finishing your PhD and on starting your postdoc in the Arnold Group at Caltech!
|
Mon 16 Sep 2013
|
Congratulations to Sara for finishing your PhD and on starting your postdoc in the Haile Group at Caltech!
|
Tue 13 Aug 2013
|
The group's latest paper,
"Catalytic Proton Reduction with Transition Metal Complexes of the Redox-active Ligand bpy2PYMe,"
appeared in Chemical Science.
|
Wed 3 Jul 2013
|
Vivian and Alex's paper
on cell-trappable hydrogen sulfide probes
was highlighted in a Faculty of 1000
Recommendation.
|
Tue 25 Jun 2013
|
Vivian and Bryan's chapter,
"Boronate-Based Fluorescent Probes: Imaging Hydrogen Peroxide in Living Systems,"
appeared in the latest volume of Methods in Enzymology.
|
Mon 17 Jun 2013
|
Vivian and Alex's paper
on cell-trappable hydrogen sulfide probes
was highlighted in a Chemical Research in Toxicology
Spotlight.
|
Fri 7 Jun 2013
|
Bryan and Vivian's paper,
"Preparation and use of MitoPY1 for imaging hydrogen peroxide in mitochondria of live cells,"
appeared in Nature Protocols.
|
Tue 28 May 2013
|
The lab's work on copper imaging
was profiled in an
LBNL News Highlight.
|
Tue 23 Apr 2013
|
Vivian and Alex's paper
was highlighted in
C&E News.
|
Thu 18 Apr 2013
|
Vivian and Alex's paper,
"Cell-trappable Fluorescent Probes for Endogenous Hydrogen Sulfide Signaling and Imaging H2O2-Dependent H2S Production,"
appeared in PNAS.
|
Fri 22 Feb 2013
|
Amanda, Nick, and Julian's paper,
"A Mechanistic Study of Proton Reduction Catalyzed by a Pentapyridine Cobalt Complex: Evidence for Involvement of an Anation-Based Pathway,"
appeared in Chemical Science.
|
Sun 27 Jan 2013
|
Genevieve's paper,
"Strategy for Dual-Analyte Luciferin Imaging: In Vivo Bioluminescence Detection of Hydrogen Peroxide and Caspase Activity in a Murine Model of Acute Inflammation,"
appeared in JACS.
|
Mon 21 Jan 2013
|
Congratulations to Mike on graduating, and best of luck at Gmab!
|
Mon 21 Jan 2013
|
Best of luck to Amanda at Los Alamos National Lab!
|
Mon 21 Jan 2013
|
Congratulations to Genevieve on graduating, and best of luck in your postdoc at Harvard/MGH!
|
Thu 13 Dec 2012
|
Jeff and Sheel's review,
"Reaction-based small-molecule fluorescent probes for chemoselective bioimaging,"
appeared in Nature Chemistry.
|
Mon 22 Oct 2012
|
Sara and Yujie's review,
"Complexes of earth-abundant metals for catalytic electrochemical hydrogen generation under aqueous conditions,"
appeared in Chemical Society Reviews.
|
Mon 22 Oct 2012
|
Vivian's review on
fluorescent probes for H2S
appeared in Current Opinion in Chemical Biology.
|
Mon 24 Sep 2012
|
Yujie's paper,
"Photocatalytic generation of hydrogen from water using a cobalt pentapyridine complex in combination with molecular and semiconductor nanowire photosensitizers,"
appeared in Chemical Science.
|
Mon 24 Sep 2012
|
Brian and Alex's paper on a reaction-based fluorescent
probe for carbon monoxide was highlighted
in C&E News.
|
Sun 16 Sep 2012
|
Brian and Alex's paper on a reaction-based fluorescent
probe for carbon monoxide appeared in JACS.
|
Sun 26 Aug 2012
|
Congratulations to Chang lab alumnus Bryan Dickinson for winning the Nobel Laureate Signature Award from the ACS for best thesis!
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Sun 26 Aug 2012
|
Hill, Mike, and Nick's paper on vanadium organoazide complexes and their conversion to
terminal vanadium imides appeared in Inorganic Chemistry.
|
Tue 31 Jul 2012
|
Congratulations to Julian on earning your PhD! Best of luck at Kinestral Technologies.
|
Tue 31 Jul 2012
|
Congratulations to Alex on starting your lab at SMU Chemistry! Best of luck in your independent career.
|
Tue 24 Apr 2012
|
Ho Yu and Liz's
paper,
"A selective reaction-based fluorescent probe for detecting cobalt in living cells,"
appeared in ChemComm.
|
Mon 23 Apr 2012
|
Sara and Hema's
paper,
"Electrochemical generation of hydrogen from acetic acid using a molecular molybdenum-oxo catalyst,"
appeared in Energy and Environmental Science.
|
Wed 18 Apr 2012
|
Emily and Liz's
paper,
"A cell-permeable gadolinium contrast agent for magnetic resonance imaging of copper in a Menkes disease model,"
appeared in Chemical Science today.
|
Thu 8 Mar 2012
|
Sara and Hema's
paper,
"Computational and Experimental Study of the Mechanism of Hydrogen Generation from Water by a Molecular Molybdenum-Oxo Electrocatalyst,"
appeared in JACS today.
|
Fri 10 Feb 2012
|
Hema and Yujie's
paper,
"A Molecular MoS2 Edge Site Mimic for Catalytic Hydrogen Generation,"
appeared in Science and was highlighted in a
UC Berkeley press release,
an
LBNL press release,
a
Daily Cal article,
and a
C&E News article.
|
Wed 1 Feb 2012
|
Genevieve and Tasuku's
paper
on a fluorescent near-IR probe for imaging copper in living mice
appeared today in PNAS.
|
Wed 4 Jan 2012
|
Julian and Hill's
paper,
"A High-Spin Iron(IV)-Oxo Complex Supported by a Trigonal Nonheme Pyrrolide Platform,"
appeared today in JACS.
|
Fri 28 Oct 2011
|
Alex and Liz's
paper
on fluorescent reaction-based H2S probes
was featured in C&E News.
|
Tue 6 Sep 2011
|
Bryan's
paper
on a nuclear H2O2 probe and its use in monitoring sirtuin-mediated oxidative stress
appeared in Chemistry & Biology.
|
Thu 11 Aug 2011
|
Alex and Genevieve's
review
appeared today in Accounts of Chemical Research.
|
Wed 3 Aug 2011
|
May's
paper
on a ratiometric two-photon hydrogen peroxide probe
appeared in ChemComm.
|
Tue 19 Jul 2011
|
Bryan's
review
on the chemistry and biology of reactive oxygen species in cellular signaling and stress responses
appeared today in Nature Chemical Biology.
|
Mon 11 Jul 2011
|
Liz is the recipient of the 2011
Dalton Young Researchers Award.
Congratulations!
|
Mon 20 Jun 2011
|
Alex and Liz's paper
on
a selective H2S probe
appeared in JACS.
|
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Wed 25 May 2011
|
Yujie, Julian, and Nick's paper
on
molecular cobalt pentapyridine catalysts for generating hydrogen from water
appeared today in JACS.
|
Mon 16 May 2011
|
Sheel's paper
on
a new mitochondrial copper probe and its application to
imaging mitochondrial copper pools in fibroblasts with mutant SCO1 and SCO2 enzymes
appeared today in JACS.
|
Tue 10 May 2011
|
Sara's paper
on
nickel N-heterocyclic carbene-pyridine complexes that exhibit selectivity for electrocatalytic reduction of carbon dioxide over water
appeared today in ChemComm.
|
Tue 29 Mar 2011
|
Sheel, Dylan, Christine, and Evan's paper
on copper redistributions in neuronal cells appeared yesterday in PNAS.
|
Mon 21 Mar 2011
|
May and Aaron's paper
on a dendrimer-based fluorescent sensor for imaging
H2O2 and pH gradients in cells appeared last week in Chemical Science.
|
Wed 9 Mar 2011
|
Added today: a new group photo and pictures of
Dylan's going away party at Albany Bowl.
|
Sat 5 Mar 2011
|
Alex's paper on a
hyperpolarized 13C MRI probe for hydrogen peroxide appeared this week in JACS.
|
Thu 10 Feb 2011
|
Genevieve's recent
PNAS paper
on hydrogen peroxide imaging in mice
was
featured
on the Lawrence Berkeley Lab website.
|
Wed 2 Feb 2011
|
Nick, Mike, and Hill's paper
on a vanadium complex that binds nitrous oxide appeared today in JACS.
|
Tue 11 Jan 2011
|
Bryan's paper
on H2O2 imaging in neural stem cells and Genevieve's
paper on
H2O2 imaging in live mice were
highlighted in C&E News.
|
Fri 31 Dec 2010
|
Added today: photos from Anne's going away party at Jupiter.
|
Sun 26 Dec 2010
|
Bryan's
paper
on redox signaling in neural stem cells appeared today in Nature Chemical Biology.
|
Wed 22 Dec 2010
|
Genevieve's recent
PNAS paper
on hydrogen peroxide imaging in mice
was given a "must read" rating by the
Faculty of 1000.
|
Wed 8 Dec 2010
|
Hill's paper
on slow magnetic relaxation in trigonal pyramidal iron(II) pyrrolide complexes
appeared today in JACS.
|
Mon 29 Nov 2010
|
Genevieve's paper
on hydrogen peroxide imaging in mice appeared today in PNAS.
|
Mon 22 Nov 2010
|
Evan, Carl, and Liz's paper
describing a photocaged hydrogen peroxide generator appeared last week in JACS.
|
Fri 5 Nov 2010
|
Added today: photos of Bryan's going away party at the Trappist.
|
Mon 1 Nov 2010
|
Congratulations to Bryan on earning your Ph.D. Best of luck at Harvard!
|
Thu 21 Oct 2010
|
Evan and Bryan's recent
PNAS paper
on the role of aquaporins in cellular uptake of hydrogen peroxide
was highlighted in
ACS Chemical Biology
and was given a "must read" rating by the
Faculty of 1000.
|
Tue 31 Aug 2010
|
Congratulations to Hill on earning your Ph.D. and Danielle on earning your M.S. Best of luck to both of you at Caltech!
|
Tue 31 Aug 2010
|
Fall group meetings start Sep 1. First-years, join us for pizza on Wednesdays at 7:00pm in 775B Tan.
|
Tue 24 Aug 2010
|
Added today: Techniques that we use in our research.
|
Thu 19 Aug 2010
|
Added today: Bryan's photo album.
|
Thu 19 Aug 2010
|
Added today: Photos of group dinner and Pink Saturday and
Hawaii retreat, 2009.
|
Wed 18 Aug 2010
|
Added today: Photos of the group trip to the Giants game on HHMI Staff Appreciation Day.
|
Tue 17 Aug 2010
|
First-year students: join us for our group meeting tonight in 775B Tan at 7:00pm.
|
Tue 17 Aug 2010
|
The Chang Lab welcomes the new first-year students to the department!
Come visit us at the Chembio
poster session today (noon-2pm, 775 Tan) or in our labs (401, 535, 610 Latimer).
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