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Jayajit Das Postdoctoral Fellow Mailing address: 66-580, Department of Chemical Engineering, Massachusetts Institute of Technology Cambridge MA 02139 Email: jayajit @ mit.edu Phone: 617-252-1744 |
Research
Jayajit Das
Postdoctoral Fellow
Mailing address: 66-580, Department of Chemical Engineering, Massachusetts Institute of Technology Cambridge MA 02139
Email: jayajit @ mit.edu
Phone: 617-252-1744
Research
Computational modeling of activation and signaling in immune system
We have investigated the effect of receptor clustering and antigen quality on activation and signaling of T lymphocytes using in silico modeling synergistic with experiments done in Shaw Lab, Washington Univ., St. Louis. Currenly I am studying the effect of antagonists, self-peptides and agonist peptides on T cell signaling. Further details can be found here.
Multiscale modeling of functional polymers
In collaboration with Prof. J. M. J. Fréchet's (UC, Berkeley) group, we have studied the single molecule conformations of a dendronized polymer chain using Monte Carlo simulations to discover that dendronized polymers are single molecule glasses. Used real space self-consistent field theoretic computer simulations to investigate the self-assembly of dendronized chains to form microphases that may mimic ion channels. In collaboration with Prof. Nitash Balsara's group (UC, Berkeley), we studied the phase behavior of crosslinked di-block copolymers using Random Phase Approximation and Replica field theory. Further details can be found here.
Selected publications
1. S. Cemerski, Jayajit Das, Jason Locasale, Paul M. Allen, Arup K. Chakraborty and Andrey S. Shaw, "Signaling in the Immunological Synapse Depends upon Antigen Quality in a Non-monotonic Manner", Nature Immunology , in review.
2. Jayajit Das, Masaru Yoshida, Zachary Fresco, Tae-Lim Choi, J. M. J. Fréchet and A. K. Chakraborty, "A Dendronized Polymer is a Single Molecule Glass" Journal of Physical Chemistry B 109 , 6535 (2005).
3. Enrique D. Gomez, Jayajit Das, Arup K. Chakraborty, John A. Pople and Nitash P. Balsara,"Effect of Crosslinking on the Structure and Thermodynamics of Lamellar Block Copolymers", Macromolecules, in review.
4. Jayajit Das, Madan Rao and Sriram Ramaswamy, "Nonequilibrium Criticality, Spatio-temporal Chaos and Control", Europhysics Letters 60 , 418(2002) .
Complete list can be found here.
Curriculum Vitae